EURYTHMIC Injection 3ml (N)

Introduction About EURYTHMIC INJECTION

EURYTHMIC INJECTION contains Amiodarone which belongs to the group of medicines
called Antiarrhythmics. It is used to manage uneven or fast heartbeats (like
atrial flutter or atrial fibrillation), fast heartbeats which may happen
suddenly and may be uneven only when other medicines either have not worked or
cannot be used.

It also manages Wolff-Parkinson-White Syndrome (unusually fast heartbeats). It
is normally only given in a hospital when a quick response is needed or when
tablets cannot be given.

Your doctor might want you to keep out of direct sunlight while receiving
EURYTHMIC INJECTION and for a few months after you have finished receiving it.
Avoid consum
EURYTHMIC INJECTION.

EURYTHMIC INJECTION is not recommended for use if you have severe breathing and
blood circulation problems, slower than usual heartbeat (called ‘sinus
bradycardia’) or an illness called sino-atrial heart block.

It is also not recommended if you have other problems with your heartbeat
without a pacemaker fitted, are going to have a heart transplantation, have ever
had thyroid problems or low blood pressure.

Before receiving EURYTHMIC INJECTION, inform your doctor if you have heart
failure or weak heart (cardiomyopathy), liver, kidney, thyroid, lung problems or
asthma, require oxygen management, are to undergo a general anesthetic, or have
eyesight problems (o

Also inform your doctor if you are about to have any surgery, blistering or
peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like
symptoms and fever (Stevens-Johnson syndrome), layers of the skin skin peeling
off to leave large areas of raw exposed skin over the body (Toxic Epidermal
Necrolysis).

EURYTHMIC INJECTION is not recommended for pregnant or breastfeeding women.
EURYTHMIC INJECTION is contraindicated in premature babies or neonates and
should be used with caution in infants and children up to 3 years old. Safety
data has not been established in children and adolescents above 3 years of age.

EURYTHMIC INJECTION should be used with caution in elderly patients above 60
years of age. The most common side effects of receiving EURYTHMIC INJECTION are
blurred eyesight, rashes, muscle weakness, difficulty sleeping, nightmares.
Consult your doctor if any of the symptoms worsen.

Uses Of EURYTHMIC INJECTION

It is usually used in hospitals when tablets cannot be given and a quick
response is needed to manage:

• sudden fast or uneven heartbeats (atrial flutter or atrial fibrillation) when other medicines either have not worked or cannot be used
• Wolff-Parkinson-White Syndrome

How EURYTHMIC INJECTION Works

EURYTHMIC INJECTION works by blocking certain electrical signals and reducing
the excitability of cardiac tissues which manages the initiation and conduction
of any new impulses in the heart that cause irregular heartbeats, thus making
your heartbeat return to normal.

How to use EURYTHMIC INJECTION

EURYTHMIC INJECTION must be given by a doctor or nurse into the vein as an
intravenous injection or infusion. Your doctor will decide the correct dose and
duration of EURYTHMIC INJECTION for you depending upon your age, body weight and
disease condition.

Side Effects Of EURYTHMIC INJECTION

Common

• blurred eyesight or seeing a colorful halo in dazzling light
• tanning more easily in the sun
• red rash with itching
• slightly slower heartbeat, reduced blood pressure (dizziness, light-headedness, fainting)
• reactions at injection site (swelling, pain, redness, infection, blue or gray marks on parts of your skin exposed to sunlight, especially the face)
• hyperthyroidism (feeling extremely restless or agitated, weight loss, too much sweating and unbearable heat)
• hypothyroidism (feeling extremely tired or weak, weight gain, unbearable cold, constipation and muscle pain)
• shivering when you move your arms or legs, weak muscles
• nightmares, sleep problems
• reduced sex drive

Uncommon

• numbness, weakness, tingling or burning feelings in any part of your body

Rare

• hypersensitivity reactions (due to an excipient- benzyl alcohol)

Stop receiving EURYTHMIC INJECTION and consult your doctor immediately if you
experience any of the following side effects:

• allergic reaction (rash, difficulty swallowing or breathing, swollen eyelids, face, lips, throat or tongue)
• very slow or no heartbeats (dizziness, tiredness, breathlessness)
• more uneven or unstable heartbeats (can lead to heart attack)
• liver problems or damage (yellowing of the skin or eyes, tiredness, nausea, loss of appetite, stomach pain or fever)
• lung inflammation (breathlessness or tightness in the chest, coughing which will not go away, wheezing or weight loss)
• torsade de pointes (life-threatening irregular heartbeat)
• Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, and flu-like symptoms)
• toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, chills and muscle pain)
• bullous dermatitis (fluid filled blisters on the skin)
• problem with your brain (headache (usually worse in the morning or happens after coughing or straining), nausea, fits, confusion))
• flu like symptoms and a rash on the face followed by an extended rash with a high temperature, enlarged lymph nodes (DRESS)

How To Manage Side Effects

Dizziness, Fainting:

When you start receiving EURYTHMIC INJECTION, you may feel faint or dizzy. This
is caused by your blood pressure dropping. If this happens, resting or lying
down for some time can help. Consult your doctor if symptoms don't improve.

Rash:

Applying a cold compress, cool showers or damp cloth, cold water can bring
immediate relief to swelling and reduce itching. Consult your doctor if symptoms
don't improve.

Muscle pain:

Hot compress helps to increase blood flow, which relaxes sore muscles and joints
and reduces pain. Cold compress can reduce inflammation around the aching muscle
or joint. Consult your doctor if symptoms don't improve.

Warning & Precautions

!### Pregnancy

EURYTHMIC INJECTION is not recommended for use in pregnant women or women
planning to have a baby, except in life-threatening circumstances. Consult your
doctor before receiving it.

!### Breastfeeding

EURYTHMIC INJECTION is not recommended for use in breastfeeding women. Consult
your doctor before receiving it.

!### Driving and Using Machines

EURYTHMIC INJECTION may affect your ability to drive or use machines. Consult
your doctor before receiving it.

!### Alcohol

Limit the consum
Consult your doctor before receiving it.

!### Kidney

EURYTHMIC INJECTION should be received with caution in patients with kidney
problems. Consult your doctor before receiving EURYTHMIC INJECTION.

!### Liver

EURYTHMIC INJECTION should be received with caution in patients with liver
problems. Consult your doctor before receiving it.

!### Allergy

Do not receive EURYTHMIC INJECTION if you are allergic to Amiodarone or any of
the other ingredients of this medicine. Consult your doctor before receiving it.

!### Lungs

EURYTHMIC INJECTION is not recommended for use if you have severe breathing
problems. EURYTHMIC INJECTION should be received with caution in patients with
asthma, or any other lung diseases. Consult your doctor before receiving it.

!### Heart Disease

EURYTHMIC INJECTION should not be given in patients with slower than usual
heartbeat (called ‘sinus bradycardia’) or an illness called sino-atrial heart
block, other problems with your heartbeat without a pacemaker fitted, are going
to have a heart transplantation or have low blood pressure.

EURYTHMIC INJECTION should be used cautiously in patients with heart failure or
weak heart (cardiomyopathy) or low blood pressure. Consult your doctor before
receiving EURYTHMIC INJECTION.

Others

EURYTHMIC INJECTION is not recommended for use if you:

• have or have earlier had any thyroid problems
• have blood circulation problems

Before receiving EURYTHMIC INJECTION, inform your doctor if you:

• have any issues with your eyesight (o
• are about to have any surgery
• have Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever)
• have toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, fever, chills and muscle pain)
• require oxygen management or are to undergo a general anesthetic
• have thyroid problems

Use in pediatrics:

EURYTHMIC INJECTION is contraindicated in premature babies or neonates and
should be used with caution in infants and children up to 3 years old.

Safety data has not been established in children and adolescents above 3 years
of age.

Use in geriatrics:

EURYTHMIC INJECTION should be used with caution in elderly patients aged above
60 years. Consult your doctor before receiving EURYTHMIC INJECTION.

Interactions

A. Drug - Drug interactions:

Before receiving EURYTHMIC INJECTION, inform your doctor if you are taking any
of the following medicine:

• other medicines used to manage uneven heartbeats (Ex. sotalol, quinidine, procainamide, disopyramide, flecainide, bretylium or amiodarone tablets)
• medicines used to improve blood supply to the brain (Ex. vincamine).
• medicines used to manage other mental illnesses like depression (Ex. sultopride, sulpiride, pimozide, lithium, doxepin, maprotiline, amitriptyline, clomipramine, dosulepin, imipramine, lofepramine, nortriptyline or trimipramine)
• medicines used to manage infections (Ex. intra-venous erythromycin, co-trimoxazole, moxifloxacin, pentamidine, clarithromycin, ciprofloxacin, ofloxacin, levofloxacin or injections of pentamide)
• medicines used to manage schizophrenia (Ex. chlorpromazine, fluphenazine, thioridazine, haloperidol, sertindole or amisulpride)
• medicines used to manage hay fever, rashes or other allergies (Ex. terfenadine, astemizole or mizolastine)
• medicines used to manage malaria (Ex. quinine, mefloquine, chloroquine or halofantrine)
• medicines used to manage hepatitis C (Ex. sofosbuvir, daclatasvir, simeprevir or ledispasvir)
• medicine used to manage heart problems (such as high blood pressure, chest pain or high cholesterol) (Ex. propranolol, flecainide, diltiazem, verapamil, furosemide, simvastatin, atorvastatin or digitalis)
• medicines used to manage digestive problems like constipation (Ex. cisapride, droperidol, bisacodyl or senna)
• medicines used to manage fungal infection (Ex. amphotericin IV)
• medicines used to manage inflammation (Ex. hydrocortisone, betamethasone or prednisolone)
• medicines which may change the levels of potassium or magnesium in your blood Ex. diuretics (water tablets), steroid tablets
• medicines for high cholesterol called statins (e.g. simvastatin or atorvastatin).
• medicines used to manage fits (Ex. phenytoin)
• medicines used during surgery (Ex. lidocaine, midazolam, triazolam or high dose oxygen)
• medicines used to test some hormone problems (Ex. tetracosactide)
• medicines used to manage rejection of transplants (Ex. ciclosporin, tacrolimus and sirolimus)
• medicines used to manage erection problems (Ex. sildenafil, tadalafil or vardenafil)
• medicines used to manage pain or migraines (Ex. fentanyl or ergotamine)
• medicines used to stop your blood from clotting (Ex. warfarin, dabigatran)
• medicine used in some blood tests or in management of Crohn’s disease (Ex. tetracosactrin)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while receiving EURYTHMIC INJECTION as it may
increase the risk of side effects.

Overdosage:

EURYTHMIC INJECTION will be given to you only by a doctor or nurse in a hospital
and so it is unlikely to receive an overdose. However, if you experience any
unusual symptoms like feeling dizzy, faint, sick, tired, confused or abnormally
slow or fast heartbeats, contact your doctor immediately.

Synopsis

Drug	:	Amiodarone
Pharmacological Category	:	Antiarrhythmic
Therapeutic Indication	:	Arrhythmias, Wolff-Parkinson-White Syndrome
Dosage Forms	:	Tablet, Injection

More Information

• Keep EURYTHMIC INJECTION out of reach of children
• Do not store above 25°C

FAQs About EURYTHMIC INJECTION

What is EURYTHMIC INJECTION used for?

EURYTHMIC INJECTION is used to manage uneven or fast heartbeats (like atrial
flutter or atrial fibrillation), fast heartbeats which may happen suddenly and
may be uneven only when other medicines either have not worked or cannot be
used. It also manages Wolff-Parkinson-White Syndrome (unusually fast
heartbeats).

How does EURYTHMIC INJECTION work?

EURYTHMIC INJECTION works by blocking certain electrical signals and reducing
the excitability of cardiac tissues which manages the initiation and conduction
of any new impulses in the heart that cause irregular heartbeats, thus making
your heartbeat return to normal.

CanEURYTHMIC INJECTION make my skin sensitive to the sun?

Yes. your skin will become much more sensitive to the sun after receiving
EURYTHMIC INJECTION and may burn, tingle or severely blister. Do not expose
yourself to direct sunlight while receiving this medicine and for a few months
after you have finished receiving it. Use high factor sun cream without fail.
Always wear a hat and clothes which cover your whole body.

What should I avoid while receiving EURYTHMIC INJECTION?

Avoid drinking grapefruit juice while receiving EURYTHMIC INJECTION as it may
increase the risk of side effects. Avoid consum
management with EURYTHMIC INJECTION, as it may increase the chances of liver
problems.

Will EURYTHMIC INJECTION cause any reaction at the site of injection?

EURYTHMIC INJECTION may cause swelling, pain, redness, infection and blue or
grey marks on parts of your skin exposed to sunlight, especially the face. You
can apply cold compress for relief. Consult your doctor before using any product
for the reaction, other than EURYTHMIC INJECTION.

Useful Diagnostic Tests

• Liver Function Test (LFT)
• Thyroid Function Test (TFT)
• Complete Blood Count (CBC)
• Chest X-Ray
• Electrocardiogram (ECG)