Dixin Injection 2ml

Introduction About DIXIN INJECTION

DIXIN INJECTION contains Digoxin which belongs to the group of medicines called
Cardiac glycosides. It is used in the management of arrhythmias (irregular
heartbeat, which causes the heart to skip a beat or beat at the wrong speed) and
heart failure. Heart failure is a chronic condition where the heart doesn’t pump
sufficient blood to other parts of the body, which is generally characterized by
symptoms such as shortness of breath, fatigue, weakness, rapid or irregular
heartbeat, and swelling in the legs, ankles or feet.

DIXIN INJECTION is not recommended for use in patients with serious heart
problems (such as stokes-Adams attacks (condition where you suddenly feel faint
and can pass out due to changes in heart rate) or irregular heartbeat due to
cardiac glycoside intoxication) and obstructive cardiomyopathy (disease that
causes your heart muscle to enlarge).

Before receiving DIXIN INJECTION, inform your doctor if you have beri-beri
disease (which occurs due to vitamin B1 deficiency), severe lung disease, kidney
disorders or liver impairment. Along management with DIXIN INJECTION, your
doctor might advise you to take regular blood test to determine the amount of
digoxin in your blood and to check the status of the kidney function, especially
in patients with kidney disorders.

DIXIN INJECTION should be used with caution in pregnant and breastfeeding women.
Also, it should be used with caution in children and adolescents (below 18 years
of age) and in elderly patients (aged 65 years and above).

The most common side effects of receiving DIXIN INJECTION are nausea, vomiting,
diarrhea, abnormal heartbeat and dizziness. Consult your doctor if any of the
side effect gets worse.

Uses Of DIXIN INJECTION

Manage:

• arrhythmia
• heart failure

How DIXIN INJECTION Works

DIXIN INJECTION works by increasing the force of contraction of the heart by
reversibly inhibiting an enzyme (responsible for controlling the movement of
ions into the heart), which leads to correction of irregular heartbeats and
strengthening of contraction force, thus helps to manage irregular heartbeat and
heart failure.

How to use DIXIN INJECTION

DIXIN INJECTION will be given to you only by a doctor or a nurse into a vein as
an intravenous infusion. Your doctor will decide the correct dose and duration
for you depending upon your age, body weight and disease condition.

Side Effects Of DIXIN INJECTION

Common

• signs of allergic reactions such as skin rash or urticaria
• abnormal heartbeat, dizziness
• nausea, vomiting
• diarrhoea
• signs of visual disturbances (such as blurred or yellow vision)

Uncommon

• depression

Rare

Inform your doctor immediately if you experience any of the following side
effects while receiving DIXIN INJECTION:

• signs of serious heart problems (caused by new irregular heartbeats) such as pounding heartbeat, chest pain, shortness of breath, and sweating
• signs of heart block (such as fainting, short-lasting loss of consciousness, dizziness, light-headedness, tiredness, shortness of breath, chest pain, irregular heartbeat, and confusion)

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Inform your doctor if the symptom gets worse.

!### Dizziness Or Drowsiness

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully,
do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid
taking caffeine or its related product. Inform your doctor if the symptom gets
worse.

!### Nausea And Vomiting

Stick to simple meals while receiving this medicine. Avoid eating oily rich,
fried or spicy foods. Do not lie down or sleep immediately after eating. Inform
your doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

DIXIN INJECTION should be used with caution during pregnancy. It is also used to
manage abnormal increase in the heart rate and congestive heart failure in the
unborn child. Consult your doctor before receiving DIXIN INJECTION.

!### Breastfeeding

DIXIN INJECTION should be used with caution in breastfeeding women as this
medicine gets excreted in small amounts through breastmilk. Consult your doctor
before receiving DIXIN INJECTION.

!### Driving and Using Machines

Do not drive or operate any machines after receiving DIXIN INJECTION as it may
cause dizziness or visual disturbances (such as yellow or blurred vision).

!### Kidney

DIXIN INJECTION should be used with caution in patients with kidney disorders.
Consult your doctor before receiving DIXIN INJECTION.

!### Liver

DIXIN INJECTION should be used with caution in patients with hepatic impairment.
Consult your doctor before receiving DIXIN INJECTION.

!### Allergy

Do not receive DIXIN INJECTION if you are allergic to Digoxin or other cardiac
glycosides (such as digitoxin) or any other ingredients of this medicine.

!### Lungs

DIXIN INJECTION should be used with caution in patients with severe respiratory
(lung) disease. Consult your doctor before receiving DIXIN INJECTION.

!### Heart Disease

DIXIN INJECTION is not recommended for use in patients with serious heart
problems such as stokes-Adams attacks (condition where you suddenly feel faint
and can pass out due to changes in heart rate) or irregular heartbeat (due to
cardiac glycoside intoxication/Wolff-Parkinson-white syndrome) and obstructive
cardiomyopathy (disease that causes your heart muscle to enlarge). It should be
used with caution in patients with heart diseases such as sinoatrial disorder
(heart rhythm disorder), recent heart attack, cardiac amyloidosis, myocarditis
(inflammation of the heart muscle), constrictive pericarditis (condition where
the walls of the fluid-filled pouch around your heart (pericardium) become too
stiff or thick), and in patients planned to receive ECG test and electric shock
management (to correct abnormal heartbeat). Consult your doctor before receiving
DIXIN INJECTION.

Others

Before receiving DIXIN INJECTION inform your doctor if you:

• have beri-beri disease (disease that occurs due to vitamin B1 deficiency)
• have signs of low levels of oxygen in the body (such as shortness of breath and tiredness)
• have signs of low levels of potassium in the blood (such as constipation, fatigue, muscle damage)
• have signs of low levels of magnesium in the blood (such as abnormal eye movements, fatigue and numbness)
• have signs of high levels of calcium in the blood (such as excessive thirst and frequent urination)
• have signs of over/under active thyroid disease (such as nervousness, mood swings, sensitivity to heat and muscle weakness)
• have signs of malabsor
• had or have gastro-intestinal reconstruction surgery

Use in Pediatrics:

DIXIN INJECTION should be used with caution in children and adolescents (below
18 years of age). Consult your child’s doctor for advice.

Use in Geriatrics:

DIXIN INJECTION should be used with caution in elderly patients (aged 65 years
and above). Consult your doctor before receiving DIXIN INJECTION.

Interactions

A. Drug-Drug interactions:

Before receiving DIXIN INJECTION inform your doctor if you are taking any of the
following medicines:

• angiotensin receptor blockers (Ex. telmisartan, irbesartan), angiotensin-converting-enzyme inhibitors (Ex. captopril, enalapril) and nifedipine, verapamil, felodipine, carvedilol, prazosin and diuretics (Ex. chlorothiazide, chlorthalidone) and beta-blockers Ex. atenolol, metoprolol, esmolol (used to manage high blood pressure)
• lithium, nefazodone st. john’s wort, bupropion (used to manage depression)
• corticosteroids (used to provide relief from inflammation) Ex. dexamethasone, hydrocortisone
• carbenoxolone (used to manage digestive tract ulcer)
• other medicines used to manage arrhythmias (Ex. amiodarone, flecainide, propafenone, quinidine, dronedarone)
• canagliflozin, acarbose (used to manage of type 2 diabetes mellitus)
• neomycin, penicillamine, rifampicin, erythromycin, clarithromycin, tetracycline, gentamicin, trimethoprim (antibiotics used to manage bacterial infections)
• telaprevir or daclatasvir, simeprevir, velpatasvir (used with or without other medicines to manage hepatitis C)
• flibanserin (used to manage low sexual desire in women who have not gone through menopause)
• isavuconazole, itraconazole (used to manage fungal infections)
• ivacaftor (used to manage cystic fibrosis)
• spironolactone (medicine used to manage heart failure)
• alprazolam (sedative used to manage anxiety)
• quinine (used to manage malaria infection)
• propantheline (used to manage muscle spasms)
• mirabegron (used to manage overactive bladder)
• atorvastatin, cholestyramine (used to manage high blood cholesterol)
• cyclosporine (used to manage organ rejection after transplantation)
• epoprostenol (used to manage pulmonary arterial hypertension)
• tolvaptan, conivaptan (used to manage low blood sodium levels)
• ritonavir (used to manage HIV infection)
• ranolazine, tiapamil (used to manage chest pain)
• lapatinib (used to manage breast cancer)
• ticagrelor (used to manage heart attack or stroke)
• vandet
• venetoclax (used to manage patients with chronic lymphocytic leukaemia)
• vemurafenib (used to manage adult patients with a type of cancer called melanoma)
• proton pump inhibitors (PPIs) (used to relieve symptoms of acid reflux) Ex. lansoprazole, omeprazole
• medicine used to manage pain and inflammation such as non-steroidal anti-inflammatory drugs (Ex. ibuprofen, naproxen, indomethacin), and COX-2 inhibitors (Ex. celecoxib, rofecoxib)
• antacids (used to manage gastric acidity) Ex. aluminum hydroxide and magnesium carbonate.
• bulk-forming laxatives (used to manage constipation) Ex. psyllium, polycarbophil
• kaolin-pectin (used to manage diarrhoea)
• cytostatic drugs such as epirubicin, bleomycin (used as chemotherapy for cancer management)
• metoclopramide (used to manage nausea and vomiting)
• sulfasalazine (used to counteract inflammatory diseases of the intestine)
• adrenaline (used to manage severe allergic reactions)
• salbutamol (used to manage asthma)
• phenytoin (used to manage epilepsy)
• supplemental enteral nutrition (used to augment nutrition)
• intravenous calcium (used to manage calcium deficiency)
• sympathomimetics (used to manage heart attack and low blood pressure) Ex. amphetamine, benzylpiperazine
• suxamethonium (used to provide anesthetic effect)

Over dosage:

DIXIN INJECTION will be administered to you only by a doctor or a nurse in a
hospital, and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms while receiving DIXIN
INJECTION such as heart rhythm disturbances, gastrointestinal symptoms (such as
loss of appetite, nausea and vomiting) dizziness, fatigue, various neurological
disturbances including visual disturbances and non-heart related symptoms (such
as weakness and general feeling of being unwell).

Synopsis

Drug	:	Digoxin
Pharmacological Category	:	Cardiac glycoside
Therapeutic Indication	:	Arrhythmias, Heart failure
Dosage Forms	:	Tablet, Injection, Syrup, Solution

More Information

• Store DIXIN INJECTION below 25°C

FAQs About DIXIN INJECTION

What are the common side effects of DIXIN INJECTION?

The most common side effects of receiving DIXIN INJECTION are allergic reactions
(signs include skin rash or urticaria), abnormal heartbeat, nausea, vomiting,
diarrhea and dizziness. Consult your doctor if any of the side effect gets worse
during management with DIXIN INJECTION.

Can DIXIN INJECTION be used in breast-feeding women?

DIXIN INJECTION should be used with caution in breastfeeding women as this
medicine gets excreted in small amounts through breastmilk. Consult your doctor
before receiving DIXIN INJECTION.

How does DIXIN INJECTION work?

DIXIN INJECTION works by increasing the force of contraction of the heart by
reversibly inhibiting an enzyme (responsible for controlling the movement of
ions into the heart), which leads to correction of irregular heartbeats and
strengthening of contraction force, thus helps to manage irregular heartbeat and
heart failure.

DoesDIXIN INJECTION cause diarrhea?

DIXIN INJECTION may cause diarrhea in some individuals. To manage this effect,
drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Inform your doctor if the symptom gets worse while
receiving DIXIN INJECTION.

Is DIXIN INJECTION safe to use in patients with kidney impairment?

DIXIN INJECTION should be used with caution in patients with kidney disorders.
Your doctor may adjust the dose based on kidney function to manage any unusual
effects. Consult your doctor before receiving DIXIN INJECTION.

Useful Diagnostic Tests

• Echocardiogram (ECG)
• Kidney function test