COGUPERIN 60 Prefilled Syringe(Pfs) 0.6ml

Introduction About COGUPERIN 60 PREFILLED SYRINGE(PFS)

COGUPERIN 60 PREFILLED SYRINGE(PFS) contains Enoxaparin which belongs to the
group of medicines called Anticoagulants. It is used to manage blood clot
formation in the body.

COGUPERIN 60 PREFILLED SYRINGE(PFS) works by stopping the blood clots formation.
It also manages the existing blood clots from growing bigger in size. Due to
this property, it is highly used as a prophylactic therapy for managing blood
clot formation during risky conditions that involves clot formation such as
before or after a surgery, during dialysis or after a heart attack or a severe
chest pain (angina).

It can also be used to reduce the risk of blood clot formation caused due to
prolong period of immobility or due to cancer therapy.

Before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) inform your doctor if you
have any liver, kidney or heart problems. You must also inform your doctor if
you have diabetes, high blood pressure or a history of stomach ulcer.

COGUPERIN 60 PREFILLED SYRINGE(PFS) is not recommended for use in patients who
are bleeding heavily or have any pre-existing conditions (such as stomach ulcer
or stroke) that can increase the risk of internal bleeding. It is also not
suitable for use in patients scheduled for spinal anesthesia or lumbar puncture.

Inform your doctor before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) if you
are pregnant or breastfeeding. The most common side effects of receiving
COGUPERIN 60 PREFILLED SYRINGE(PFS) are injection site reactions (such as pain
or irritation), skin rashes, low platelet count, bleeding or bruising and
headache. Consult your doctor if any of these side effect worsens.

Uses Of COGUPERIN 60 PREFILLED SYRINGE(PFS)

• Manage and manages blood clots in the body

How COGUPERIN 60 PREFILLED SYRINGE(PFS) Works

COGUPERIN 60 PREFILLED SYRINGE(PFS) is an anticoagulant medicine. It inactivates
certain proteins (such as coagulation factor II a and X a) in the blood that
causes blood clotting. This reduces the chances of blood clot formation within
the body which therefore manages blockage of blood vessels.

How to use COGUPERIN 60 PREFILLED SYRINGE(PFS)

COGUPERIN 60 PREFILLED SYRINGE(PFS) will be given to you only by a doctor or a
nurse into the vein (intravenously) or under the skin (subcutaneously).

It can also be self-administered by the patients if advised by the physician.
Carefully, follow the instructions given by the doctor in case of
self-administration.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of COGUPERIN 60 PREFILLED SYRINGE(PFS)

Common

• Bleeding, bruising
• Injection site reactions (such as pain or redness)
• pinky patches on the skin (especially in the injection site)
• skin rash, itching, redness
• low RBC count in blood
• headache

Uncommon

• sudden severe headache
• tender and swollen stomach

Rare

• increased blood potassium levels
• hair loss
• osteoporosis (weak and brittle bones)
• tingling, numbness and muscular weakness (especially in the lower part of the body) especially if you have had a spinal puncture or a spinal anesthetic
• loss of control over the intestine or bladder

Contact your doctor immediately if you experience any of the following side
effects after receiving COGUPERIN 60 PREFILLED SYRINGE(PFS):

• severe allergic reactions (such as skin rash, itching, swelling of the face, mouth, throat, tongue leading to difficulty in breathing or swallowing)
• signs of excessive bleeding (excessive weakness, tiredness, paleness, dizziness, headache or unexplained swelling)
• severe skin reactions (such as skin rash, itching, skin redness with blisters or peeling of the skin, which may be associated with high fever and joint pains, dark red spots under the skin)
• cramping pain, redness, warmth, swelling in one of the legs
• breathlessness, chest pain, coughing up blood

How To Manage Side Effects

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

!### Injection Site Reactions

Place an ice pack on the affected area. Do not frequently move the injection
site. Consult your doctor if the symptom did not improve.

Warning & Precautions

!### Pregnancy

Monitoring requiredCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used in pregnant women only if it
is considered necessary by the physician. Therefore, consult your doctor before
receiving it.

!### Breastfeeding

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in breastfeeding
women. Therefore, consult your doctor before receiving it.

!### Driving and Using Machines

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) does not affect your ability to drive or
operate machinery. However, do not drive or handle any heavy tools or machines
if your ability is affected by COGUPERIN 60 PREFILLED SYRINGE(PFS).

!### Alcohol

Consult your doctorAvoid consum
SYRINGE(PFS).

!### Kidney

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in patients with
kidney problems. Therefore, consult your doctor before receiving it.

!### Liver

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in patients with
liver problems. Therefore, consult your doctor before receiving it.

!### Allergy

ContraindicatedTalk to your doctor before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) if you
are allergic to Enoxaparin or to any other low molecular weight heparins (such
as nadroparin, tinzaparin or dalteparin).

!### Heart Disease

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in patients
fitted with heart valves and in patients with heart problems (such as heart
infections or high blood pressure). Therefore, consult your doctor before
receiving it.

!### Use In Pediatrics

Consult your doctorThe safety and effectiveness of COGUPERIN 60 PREFILLED SYRINGE(PFS) have not
been established in children and adolescents (aged below 18 years). Your doctor
will decide about administering COGUPERIN 60 PREFILLED SYRINGE(PFS) to your
child after evaluating the risks and benefits of the therapy.

!### Use In Geriatrics

Use with CautionCOGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in elderly
patients (aged 65 years or older). Therefore, consult your doctor before
receiving it.

Others

COGUPERIN 60 PREFILLED SYRINGE(PFS) is not recommended for use if you:

• have a previous history of heparin-induced thrombocytopenia (low platelet count in blood)
• have antibodies against enoxaparin in your blood
• are bleeding heavily
• have any internal condition that can increase the risk of heavy bleeding (such as stomach ulcer, stroke, surgery)
• are scheduled for any spinal procedures (such as spinal anesthesia or lumbar puncture)

Before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS), inform your doctor if you:

• have a history of stomach ulcers
• recently had stroke
• have diabetes
• have diabetic retinopathy (eye damage caused due to diabetes)
• recently had surgery on your brain or eyes
• are underweight or overweight
• have hyperkalemia (high blood potassium levels)

Interactions

A. Drug-Drug interactions:

Before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS), inform your doctor if you
are taking any of the following medicines:

• warfarin (a medicine used for blood thinning)
• other medicines used to stop blood clots from forming (Ex. aspirin, clopidogrel, dipyridamole)
• dextran injection (used to replace blood)
• medicines used to relieve pain and swelling (Ex. ibuprofen, diclofenac, ketorolac, tromethamine)
• medicines used to manage asthma, rheumatoid arthritis, and other conditions (Ex. prednisolone, dexamethasone)
• medicines that increase blood potassium levels (Ex. spironolactone, triamterene, amiloride)
• sulfinpyrazone (used to manage gout)

Overdosage:

COGUPERIN 60 PREFILLED SYRINGE(PFS) will be administered to you only by a doctor
or a nurse in a hospital, and so it is unlikely to receive an overdose. However,
consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Enoxaparin
Pharmacological Category	:	Parenteral Anticoagulants
Therapeutic Indication	:	Blood clots
Dosage Forms	:	Injection, Pre-filled syringes (PFS), Pen, Cartridge

More Information

• Keep COGUPERIN 60 PREFILLED SYRINGE(PFS) out of reach of children
• Store COGUPERIN 60 PREFILLED SYRINGE(PFS) at room temperature

FAQs About COGUPERIN 60 PREFILLED SYRINGE(PFS)

Q: What is the use of COGUPERIN 60 PREFILLED SYRINGE(PFS)?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) is an anticoagulant used to manage blood
clots in the body. It works by stopping the blood clots formation and manages
the existing blood clots from growing bigger in size.

Q: How COGUPERIN 60 PREFILLED SYRINGE(PFS) works?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) is an anticoagulant medicine. It
inactivates certain proteins (such as coagulation factor II a and X a) in the
blood that causes blood clotting. This reduces the chances of blood clot
formation within the body which therefore manages blockage of blood vessels.

Q: How COGUPERIN 60 PREFILLED SYRINGE(PFS) is administered?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) will be given to you only by a doctor or
a nurse into the vein (intravenously) or under the skin (subcutaneously). It can
also be self-administered by the patients if advised by the physician.
Carefully, follow the instructions given by the doctor in case of
self-administration.

Q: What precautions must be followed while receiving COGUPERIN 60 PREFILLED
SYRINGE(PFS)?

A: Before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) inform your doctor if
you have any liver, kidney or heart problems. You must also inform your doctor
if you have diabetes, high blood pressure or a history of stomach ulcer.
COGUPERIN 60 PREFILLED SYRINGE(PFS) is not recommended for use in patients who
are bleeding heavily or have any pre-existing conditions (such as stomach ulcer
or stroke) that can increase the risk of internal bleeding. It is also not
suitable for use in patients scheduled for spinal anesthesia or lumbar puncture.
Inform your doctor before receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) if you
are pregnant or breastfeeding.

Q: Is COGUPERIN 60 PREFILLED SYRINGE(PFS) safe?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) is considered safe at the doses
administered by the physician. However, consult your doctor if you experience
any unusual side effects.

Q: What are the common side effects of receiving COGUPERIN 60 PREFILLED
SYRINGE(PFS)?

A: The most common side effects of receiving COGUPERIN 60 PREFILLED SYRINGE(PFS)
are injection site reactions (such as pain or irritation), skin rashes, low
platelet count, bleeding or bruising and headache. Consult your doctor if any of
these side effect worsens.

Q: Can the use of COGUPERIN 60 PREFILLED SYRINGE(PFS) make me bleed more?

A: As COGUPERIN 60 PREFILLED SYRINGE(PFS) is a blood thinning medicine, it makes
your blood thin and flowy which might increase the risk of excessive bleeding.
To avoid this, your doctor will carefully evaluate your condition and prescribe
a suitable dose for you. As a precaution, you must also inform your doctor if
you have or recently had any surgery or have any pre-existing conditions (such
as stomach ulcer or stroke) that can increase the risk of internal bleeding.

Q: Can COGUPERIN 60 PREFILLED SYRINGE(PFS) be used during heart attack?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) can be used to manage blood clots in
patients who suffered a heart attack. However, consult your doctor before taking
it.Q:Who should not receive COGUPERIN 60 PREFILLED SYRINGE(PFS)?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) is not recommended for use in patients
who are bleeding heavily or have any pre-existing conditions (such as stomach
ulcer or stroke) that can increase the risk of internal bleeding. It is also not
suitable for use in patients scheduled for spinal anaesthesia or lumbar
puncture.

Q:Can I stop receiving COGUPERIN 60 PREFILLED SYRINGE(PFS) once my
symptoms subside?

A: Do not stop taking COGUPERIN 60 PREFILLED SYRINGE(PFS) without consulting
your doctor. You need to receive COGUPERIN 60 PREFILLED SYRINGE(PFS) for the
duration recommended by your doctor to achieve complete management of blood clot
formation within your body.

Q: Is COGUPERIN 60 PREFILLED SYRINGE(PFS) heparin?

A: Yes. COGUPERIN 60 PREFILLED SYRINGE(PFS) contains a medicine called
enoxaparin which is a low molecular weight heparin.

Q: Can I use COGUPERIN 60 PREFILLED SYRINGE(PFS) during pregnancy?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) should be used with caution in pregnant
women especially those with a mech
you may be pregnant or are planning to get pregnant, consult your doctor before
receiving COGUPERIN 60 PREFILLED SYRINGE(PFS).

Q: Can COGUPERIN 60 PREFILLED SYRINGE(PFS) be used in children?

A: The safety and effectiveness of COGUPERIN 60 PREFILLED SYRINGE(PFS) have not
been established in children and adolescents (aged below 18 years). Your doctor
will decide about administering COGUPERIN 60 PREFILLED SYRINGE(PFS) to your
child after evaluating the risks and benefits of the therapy.

Q: Can COGUPERIN 60 PREFILLED SYRINGE(PFS) be given IV?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) will be given to you only by a physician
or a nurse under the skin (subcutaneously). It can also be given into your vein
(intravenously) during surgeries or after heart attack. Your doctor will decide
the appropriate route of administration for you depending upon your medical
condition.

Q: Can COGUPERIN 60 PREFILLED SYRINGE(PFS) cause thrombocytopenia?

A: COGUPERIN 60 PREFILLED SYRINGE(PFS) can lower your blood platelet count
(thrombocytopenia), making you bruise more easily than usual. Consult your
doctor if you experience any unusual bruising.