Cenoza A 75Mg Capsule 10's

Introduction About CENOZA A 75MG CAPSULE

CENOZA A 75MG CAPSULE is a combination of Aspirin and Clopidogrel which belongs
to the group of medicines called Antiplatelets. CENOZA A 75MG CAPSULE is used in
the management of early and long-term atherothrombotic events such as myocardial
infarction (also known as heart attack), stroke (reduced blood supply to brain
leading to brain death), cardiovascular death or refractory ischemia (chest pain
due to inadequate blood supply to the heart) in patients having acute coronary
syndrome with or without cardiac revascularization (including surgical or PCI,
with or without stent insertion).

Acute coronary syndrome is a heart condition caused by plaque rupture or clot
formation in the coronary arteries. Symptoms include heart attack, chest
pressure or pain while at rest, shortness of breath and sweating.

Along management with CENOZA A 75MG CAPSULE follow a healthy low-fat diet as
advised by doctor to achieve better results. Avoid drinking alcohol during
management with CENOZA A 75MG CAPSULE, as it could increase the risk of bleeding
in the gastrointestinal tract.

Do not stop taking CENOZA A 75MG CAPSULE abruptly without consulting your doctor
because premature discontinuation of this medicine may increase the risk of
cardiovascular events. CENOZA A 75MG CAPSULE is not recommended for use in
patients having severe liver, kidney or lung disease.

CENOZA A 75MG CAPSULE is generally not recommended for use in pregnant or
breastfeeding women and in children (below 18 years). Consult your doctor for an
alternative therapy.

The most common side effects of taking CENOZA A 75MG CAPSULE are diarrhea,
nausea, stomach pain and indigestion. Contact your doctor if any of the symptoms
worsen.

Uses Of CENOZA A 75MG CAPSULE

• To manage atherothrombotic events (such as myocardial infarction, stroke, cardiovascular death or refractory ischemia) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion)

How CENOZA A 75MG CAPSULE Works

CENOZA A 75MG CAPSULE reduces the risk of heart problems, where clopidogrel acts
by irreversibly inhibiting platelet aggregation in the coronary arteries and
aspirin acts by blocking an enzyme called cyclo-oxygenase 1 which is believed to
be responsible for catalyzing the synthesis of platelets, thus leading to the
management of fatal cardiac outcomes.

How to use CENOZA A 75MG CAPSULE

Take CENOZA A 75MG CAPSULE as advised by your physician. Swallow CENOZA A 75MG
CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of CENOZA A 75MG CAPSULE

Common

• diarrhea
• stomach pain
• indigestion or heartburn

Uncommon

• nausea or vomiting
• headache, dizziness
• ulcers in the stomach, constipation, flatulence
• skin rash or itching
• sensation of tingling and numbness in the body
• runny nose
• difficulty in breathing

Rare

• vertigo (spinning sensation)
• aplastic anemia
• cramps in lower respiratory tract, asthma attack
• gynecomastia (breast enlargement in male)
• menorrhagia (abnormal heavy or prolonged menstrual periods)
• generalized allergic reactions (such as overall heat sensation with sudden general discomfort until fainting)
• hemorrhagic vasculitis (inflammation of the blood vessels with bleeding)
• granulocytosis (increased granulocytes in peripheral blood)
• decreased platelet count (signs include easy bruising or bleeding)
• signs of low neutrophil count (sore throat, mouth ulcer or susce

Stop taking CENOZA A 75MG CAPSULE and contact your doctor immediately if you
experience the following side effects:

• fever, signs of infection or extreme tiredness
• signs of Thrombotic Thrombocytopenic Purpura (such as jaundice, bruising under the skin that can appear as red pinpoints dots under the skin, confusion, fever, unexplained extreme tiredness and/or confusion)
• signs of allergic reactions (such as skin rashes, itching with blisters, swelling of the face, lips, mouth, throat or shock)
• signs of serious skin reactions like erythema multiforme, stevens-johnson syndrome or lyell’s syndrome (such as skin redness with blisters or peeling which may be associated with high fever and joint pain)
• signs of liver problems (yellowing of the skin or white of the eyes (jaundice), whether not associated with bleeding which appears under the skin (red pinpoint dots) and confusion
• unusual bleeding (such as bleeding in the brain, bruising under the skin, nasal bleeds, blood in urine, bleeding in the stomach or bowel leading to coughing up blood or black stools or bleeding in other parts of the body such as eyes, lungs or joints)

How To Manage Side Effects

Nausea and vomiting:

Try to take CENOZA A 75MG CAPSULE with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy food. Consult your doctor if the
symptom did not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much of alcohol.
Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines while you are feeling dizzy. Do not consume too much of alcohol, as it
can aggravate your dizziness. Consult your doctor if the symptom did not
improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly.
Consult your doctor if the symptom did not improve.

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink
plenty of water. Try to exercise more regularly. Consult your doctor if the
symptom did not improve on its own.

Indigestion:

Eat only when you are hungry. Try to eat smaller portions at a time. Always try
to have a nutritious snack that is high in calories and protein, such as dried
fruit and nuts. Consult your doctor if the symptom did not improve.

Warning & Precautions

!### Pregnancy

CENOZA A 75MG CAPSULE is not recommended for use during pregnancy. Consult your
doctor before taking CENOZA A 75MG CAPSULE.

!### Breastfeeding

CENOZA A 75MG CAPSULE is not recommended for use in breastfeeding women. Consult
your doctor before taking CENOZA A 75MG CAPSULE.

!### Driving and Using Machines

Do not drive or operate any heavy tools or machines if your ability is affected
by CENOZA A 75MG CAPSULE.

!### Alcohol

Avoid consum
increase the risk of gastrointestinal bleeding. Consult your doctor before
taking CENOZA A 75MG CAPSULE.

!### Kidney

CENOZA A 75MG CAPSULE is not recommended for use in patients having severe
kidney disease and should be used with caution in patients with kidney disease.
Consult your doctor before taking CENOZA A 75MG CAPSULE.

!### Liver

CENOZA A 75MG CAPSULE is not recommended for use in patients having severe liver
disease and it should be used with caution in patients with liver disease.
Consult your doctor before taking CENOZA A 75MG CAPSULE.

!### Allergy

Do not take CENOZA A 75MG CAPSULE if you are allergic to Aspirin, Clopidogrel or
any other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, celecoxib,
etoricoxib).

!### Lungs

CENOZA A 75MG CAPSULE is not recommended for use in patients having respiratory
conditions such as asthma, nasal discharge (runny nose) or polyps (a type of
growth in the nose). Consult your doctor before taking CENOZA A 75MG CAPSULE.

Others

CENOZA A 75MG CAPSULE is not recommended for use if you:

• have coagulation disorders (Ex. hemophilia, thrombocytopenia)
• have bleeding in the brain (Ex. intracr
• have bleeding in the gastrointestinal tract
• have gout
• have menorrhagia (abnormally heavy or prolonged menstrual period)

Before taking CENOZA A 75MG CAPSULE, inform your physician if you:

• have stomach ulcer or severe stomach pain
• had a recent serious injury
• are going to have any upcoming surgery (including dental procedures) or already had recently
• had a recent ischemic stroke (blot clot in the artery supplying the brain)
• have a history of asthma or other allergic diseases
• are alcoholic
• have G6PD deficiency (a genetic disorder causing destruction of red blood cells in response to certain stimuli)
• have active chickenpox or shingles infection

Use in pediatrics:

CENOZA A 75MG CAPSULE is not recommended for use in children and adolescents
(under 18 years of age). Consult your doctor for advice.

Use in geriatrics:

CENOZA A 75MG CAPSULE should be used with caution in elderly patients (aged 65
years and above). because of increased risk of gastro-intestinal bleeding and
perforation when used for prolonged duration (if prolonged therapy is essential,
patients should be reviewed regularly). Consult your doctor before taking CENOZA
A 75MG CAPSULE.

Interactions

A. Drug-Drug interactions:

Before taking CENOZA A 75MG CAPSULE inform to your doctor, if you are taking any
of these medicines:

• other anticoagulant medicines used to manage blood clots (Ex. warfarin, heparin, coumarin) or dipyridamole
• medicines used to manage stomach ulcers such as antacids (Ex. aluminium hydroxide, magnesium hydroxide) and proton-pump inhibitors (Ex. omeprazole or esomeprazole)
• other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, paracetamol)
• glycoprotein IIb/IIIa inhibitors (used during percutaneous coronary intervention) Ex. abciximab, e
• medicines used to manage heart problems or hypertension (Ex. captopril, enalapril, lisinopril)
• selective serotonin reuptake inhibitors (used to manage depression) Ex. fluoxetine, sertraline, paroxetine etc
• methotrexate (used to manage cancer and other auto immune diseases)
• diuretics (used to increase urine output) Ex. furosemide, chlorothiazide
• acetazolamide (used to manage or manage altitude sickness)
• digoxin (used to manage abnormal heart rate)
• lithium (used to manage metal illness)
• corticosteroids (used to manage pain and inflammation) Ex. prednisolone, dexamethasone
• medicines used to manage epilepsy (Ex. phenytoin, valproic acid)
• ciclosporin or tacrolimus (used to manage graft rejection or manage auto-immune disease)
• ticlopidine (an antiplatelet medicine used to manage heart problems)
• medicines used to manage gout (such as probenecid, sulfinpyrazone or benzbromarone)
• fluconazole or voriconazole (used to manage fungal infection)
• medicines used to manage HIV infection (Ex. efavirenz or tenofovir)
• varicella vaccine (used to manage chickenpox or shingles)
• moclobemide (a medicine used to manage depression)
• medicines used to control blood glucose level (Ex. glipizide, gliclazide, glimepiride, repaglinide)
• paclitaxel (used to manage certain forms of cancer)
• nicorandil (used to manage chest pain)
• mifepristone (abortion pill)
• metoclopramide (used to manage vomiting)

Overdosage:

If you or anyone else take too much of CENOZA A 75MG CAPSULE, contact your
doctor immediately or go to a hospital straight away. Overdosage symptoms of
CENOZA A 75MG CAPSULE might include increased bleeding, confusion,
disorientation, coma, convulsions, vomiting, tinnitus (ringing in the ears),
vertigo (spinning sensation), sweating, warm extremities with bounding pulses,
increased respiratory rate, hyperventilation, low blood sugar levels, low
potassium and platelets levels in blood, increased body temperature, kidney
failure, respiratory alkalosis, metabolic acidosis and pulmonary edema
(non-cardiac related).

Synopsis

Drug	:	Aspirin, Clopidogerl
Pharmacological Category	:	Antiplatelets
Therapeutic Indication	:	Myocardial infarction, Stroke, Cardiac death, Angina
Dosage Forms	:	Tablet, Capsule

More Information

• Keep CENOZA A 75MG CAPSULE out of reach of children
• Store CENOZA A 75MG CAPSULE at room temperature

FAQs About CENOZA A 75MG CAPSULE

Can CENOZA A 75MG CAPSULE be taken at night?

Always take CENOZA A 75MG CAPSULE as advised by your physician. Your doctor will
prescribe a suitable dose, frequency and time for you depending upon your age
and existing disease condition. Before taking CENOZA A 75MG CAPSULE consult your
doctor for more information regarding the direction of use.

Can I consume alcohol while taking CENOZA A 75MG CAPSULE?

No. Avoid consum
aggravate your existing disease condition and increase the risk of bleeding.
Before taking CENOZA A 75MG CAPSULE inform your doctor if you are alcoholic.

Can I take paracetamol along with CENOZA A 75MG CAPSULE?

Avoid concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) like
paracetamol or ibuprofen while taking CENOZA A 75MG CAPSULE, because it may
increase the risk of gastro-intestinal bleeding. Consult your doctor for an
alternative pain relief medicine which can be used with CENOZA A 75MG CAPSULE.

Can CENOZA A 75MG CAPSULE be used in elderly patients?

Yes. CENOZA A 75MG CAPSULE can be used in elderly patients. It should be used
with caution in elderly patients (aged 65 years and above) because of increased
risk of gastro-intestinal bleeding and perforation when used for prolonged
duration (if prolonged therapy is essential, patients should be reviewed
regularly). Consult your doctor before taking CENOZA A 75MG CAPSULE.

Can CENOZA A 75MG CAPSULE be used in pregnancy?

No. CENOZA A 75MG CAPSULE is strictly not recommended for use during pregnancy.
If you are pregnant or suspect that you are pregnant, you should inform your
doctor before taking CENOZA A 75MG CAPSULE.

What to do If I forget to take CENOZA A 75MG CAPSULE?

You should take CENOZA A 75MG CAPSULE immediately when you remember. If it is
time for your next dose of CENOZA A 75MG CAPSULE skip the dose and follow your
regular dose schedule. Do not double the dose to match up your missed dose.

Useful Diagnostic Tests

• Complete blood count
• Kidney function test
• Liver function test