Butrum 2mg Injection 1ml

Introduction About BUTRUM 2MG INJECTION

BUTRUM 2MG INJECTION contains Butorphanol, which belongs to the group of
medicines called Opioid agonist/antagonist analgesics. It is used to manage and
relieve moderate to severe pain. It is also used as a
preoperative/pre-anaesthetic medication, a supplement to balanced anaesthesia,
to provide relief from pain during labor and in the management of severe pain
for which alternative management is inadequate.

BUTRUM 2MG INJECTION is not recommended for use in patients with lung problems
(such as respiratory depression, acute/severe bronchial asthma) and
gastrointestinal obstruction (such as paralytic ileus). Before taking BUTRUM 2MG
INJECTION, inform your doctor if you have a dependency on narcotics, suffer from
cachexia (a condition marked by extreme weight loss and muscle wasting), seizure
disorders or hepatic and/or kidney impairment.

BUTRUM 2MG INJECTION should be used with caution in pregnant and breastfeeding
women only if necessary. It is not recommended for use in children and
adolescents (aged below 18 years). It should be used with caution in elderly
patients (aged above 65 years).

The most common side effects associated with the use of BUTRUM 2MG INJECTION are
excessive sleepiness, dizziness, nausea, vomiting, nasal congestion,
sleeplessness and/or lethargy. Consult your doctor if any of your symptoms get
worse.

Uses Of BUTRUM 2MG INJECTION

• Management of moderate to severe pain
• Preoperative and pre-anaesthetic medication
• Supplement to balanced anaesthesia

How BUTRUM 2MG INJECTION Works

BUTRUM 2MG INJECTION works by blocking certain receptors (responsible for pain)
in the brain and spinal cord which leads to blockage of pain transmission thus
providing relief from moderate to severe acute pain in affected individuals.

How to use BUTRUM 2MG INJECTION

BUTRUM 2MG INJECTION will be given to you only by a doctor or a nurse into the
vein as an intravenous injection or into the muscle as an intramuscular
injection. Your doctor will decide the correct dose and duration for you
depending on your age, body weight and disease condition.

Side Effects Of BUTRUM 2MG INJECTION

Common

• excess sleepiness
• dizziness
• nausea and/or vomiting
• lethargy
• headache
• sensation of heat
• signs of dilation of vessels such as nausea, blurred vision, light-headedness or dizziness
• pounding heartbeat
• anorexia (an eating disorder causing weight or weight loss)
• constipation
• dry mouth
• stomach pain
• anxiety
• confusion
• euphoria (feeling very happy)
• floating feeling
• sleeplessness
• nervousness
• stinging sensation
• tremor
• cough
• shortness of breath
• sweating
• itching
• blurred vision
• ear pain
• ringing sensation in ears
• unpleasant taste

Uncommon

• low blood pressure
• transient loss of consciousness
• abnormal dreams
• agitation
• dysphoria (feeling of being unhappy)
• hallucinations (a false perce
• hostility
• withdrawal symptoms such as fatigue, anxiety, vomiting, sweating, depression
• rashes/itchy welts
• impaired urination
• swelling due to water retention
• chest pain
• high blood pressure
• depression
• shallow breathing

Rare

• dip in blood pressure associated with loss of consciousness during the first hour of dosing of medicine
• severe high blood pressure
• signs of serotonin syndrome (life-threatening drug reaction of serotonin) such as agitation, confusion, dilated pupils
• severe breathlessness in infants

Stop receiving BUTRUM 2MG INJECTION and contact your doctor if you experience
any of the following side effects:

• signs of severe hypertension such as anxiety, blurred vision, chest pain
• signs of serotonin syndrome (life-threatening drug reaction of serotonin) such as agitation, confusion, dilated pupils
• stop breastfeeding your baby and consult your doctor immediately if your baby develops increased sleepiness, breathing difficulties and/or limpness

How To Manage Side Effects

Headache

Take rest and relax. Stay hydrated. Do not skip your meals. Consult your doctor
if the condition persists or gets worse.

Dizziness

Lie down until the dizziness passes and try to get up slowly. Do not bend down
suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids to
stay hydrated. Avoid drinking coffee, alcohol or smoking. Consult your doctor if
the condition persists or gets worse.

Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). Consult your doctor if the condition persists or gets worse.

Nausea and vomiting

Try to take BUTRUM 2MG INJECTION with or just after a meal or a snack. Stick to
simple meals. Avoid eating rich or spicy foods. Consult your doctor if the
symptom gets worse.

Warning & Precautions

!### Pregnancy

BUTRUM 2MG INJECTION should be used with caution during pregnancy only if it is
necessary as prolonged use of this medicine might cause physical dependence and
neonatal opioid withdrawal syndrome in new-born which can be associated with
symptoms such as irritability, abnormal sleep pattern, high-pitched crying and
tremors. Consult your doctor before receiving the medicine.

!### Breastfeeding

BUTRUM 2MG INJECTION should be used with caution in breastfeeding women only if
it is clearly necessary as it can pass through breastfed milk. Stop
breastfeeding your baby and consult your doctor immediately if your baby
develops increased sleepiness, breathing difficulties and/or limpness after
breastfeeding. Consult your doctor for advice before receiving the medicine.

!### Driving and Using Machines

Do not drive or operate machines after receiving BUTRUM 2MG INJECTION as it can
impair the mental and/or physical abilities to drive or operate machinery.
Consult your doctor before receiving the medicine.

!### Alcohol

Avoid consum
cause substance abuse, profound sedation, respiratory depression and/or coma.

!### Kidney

BUTRUM 2MG INJECTION should be used with caution in patients with renal
impairment. Consult your doctor before receiving the medicine.

!### Liver

BUTRUM 2MG INJECTION should be used with caution in patients with hepatic
impairment. Consult your doctor before receiving the medicine.

!### Allergy

Do not receive BUTRUM 2MG INJECTION if you are allergic to butorphanol tartrate
and/or any other ingredients in this medicine.

!### Lungs

BUTRUM 2MG INJECTION is not recommended for use in patients with lung problems
such as significant respiratory depression or acute/severe bronchial asthma (in
an unmonitored setting). It should be used with caution in patients with other
lung diseases such as chronic obstructive pulmonary disease, substantially
decreased respiratory reserve, hypoxia, hypercapnia and/or respiratory
impairment. Consult your doctor before receiving the medication.

!### Heart Disease

BUTRUM 2MG INJECTION should be used with caution in patients with heart diseases
such as acute myocardial infarction, ventricular dysfunction and/or coronary
insufficiency only if clearly necessary. Consult your doctor before receiving
the medicine.

Others

BUTRUM 2MG INJECTION is not recommended for use if you:

• have/suspected of gastrointestinal obstruction such as paralytic ileus

Before receiving BUTRUM 2MG INJECTION, inform your doctor if you:

• are dependent on narcotics
• suffer from cachexia (a condition marked by extreme weight loss and muscle wasting)
• are a debilitated patient
• have a head injury and suffer from impaired consciousness and/or coma
• have seizure disorders

Use in Paediatrics

BUTRUM 2MG INJECTION is not recommended for use in children and adolescents
(below 18 years of age). Consult your doctor before receiving the medicine.

Use in Geriatrics

BUTRUM 2MG INJECTION should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before receiving the medicine.

Interactions

A. Drug-Drug Interactions:

Before receiving BUTRUM 2MG INJECTION, inform your doctor, if you are taking any
of the following medicine:

• sedatives/hypnotics (medicines used to manage sleep disorders) such as barbiturates Ex. amobarbital
• anxiolytics or tranquilizers such as benzodiazepines (medicines used to manage anxiety) Ex. diazepam
• medicines used to manage depression, such as selective serotonin reuptake inhibitors (Ex. citalopram), serotonin and norepinephrine reuptake inhibitors (Ex. paroxetine), tricyclic antidepressants (Ex. amoxapine)
• medicines that can affect the metabolism of certain drugs in the liver (Ex. erythromycin, theophylline)
• monoamine oxidase (MAO) inhibitors (medicines used to manage psychiatric disorders) Ex. linezolid, intravenous methylene blue
• triptans (medicines used to manage migraine) Ex. sumatriptan
• 5-HT3 receptor antagonists (medicines used to manage nausea and vomiting) Ex. ondansetron
• mirtazapine, trazodone, tramadol (medicines that affect the serotonin neurotransmitter system)
• muscle relaxants (medicines used for muscle relaxation) Ex. cyclobenzaprine, metaxalone
• general anaesthetics (medicines used to minimize pain threshold in the whole body) Ex. propofol
• antipsychotics (medicines used to manage psychotic disorders) Ex. risperidone
• other opioids (medicines used to block opioid receptors) Ex. fentanyl

Overdosage:

BUTRUM 2MG INJECTION will be given to you only by a doctor or nurse in a
hospital, so it is unlikely for you to receive an overdose. However, if you
experience any unusual symptoms, consult your doctor immediately or visit the
nearby hospital. Symptoms may include respiratory depression, sleepiness that
may prolong to the state of loss of consciousness/coma, skeletal muscle
flaccidity, cold & clammy skin, constricted pupils, swelling in the lungs, low
heart rate, low blood pressure, partial/complete airway obstruction, atypical
snoring and/or hypoxia.

Synopsis

Drug	:	Butorphanol
Pharmacological Category	:	Opioid agonist/antagonist analgesics
Therapeutic Indication	:	Management of Moderate to severe pain
Dosage Forms	:	Injection, Nasal Spray

More Information

• Keep BUTRUM 2MG INJECTION out of reach from children
• Store the medicine at 20 to 25°C

FAQs About BUTRUM 2MG INJECTION

What BUTRUM 2MG INJECTION is used for?

BUTRUM 2MG INJECTION is used as a preoperative/pre-anaesthetic medication which
is also used as a supplement to balanced anaesthesia. It is also used to relieve
pain during labour, after a surgical procedure and in the management of severe
pain when an alternative management becomes inadequate as management in affected
individuals.

What happens if you take more BUTRUM 2MG INJECTION than your required dose?

BUTRUM 2MG INJECTION will be given to you only by a doctor or nurse in a
hospital, so it is unlikely for you to receive an overdose. However, if you
experience any unusual symptoms, consult your doctor immediately or visit the
nearby hospital. Symptoms may include respiratory depression, sleepiness that
may prolong to the state of loss of consciousness/coma, skeletal muscle
flaccidity, cold & clammy skin, constricted pupils, swelling in the lungs, low
heart rate, low blood pressure, partial/complete airway obstruction, atypical
snoring and/or hypoxia.

What side effects of BUTRUM 2MG INJECTION?

The most common side effects associated with the use of BUTRUM 2MG INJECTION are
excess sleepiness, dizziness, nausea, vomiting, lethargy, headache and/or
constipation. Consult your doctor if any of these symptoms worsen.

Who should avoid receiving BUTRUM 2MG INJECTION?

BUTRUM 2MG INJECTION is not recommended for use in patients allergic to
butorphanol tartrate. It is also not recommended for use in patients with lung
problems (such as respiratory depression, acute/severe bronchial asthma) and
gastrointestinal obstruction (such as paralytic ileus). It is also not
recommended for use in children and adolescents (aged below 18 years). Consult
your doctor before receiving BUTRUM 2MG INJECTION.

Can alcohol be consumed after receiving BUTRUM 2MG INJECTION?

Avoid consum
cause drowsiness, dizziness and/or impaired mental function. Consult your doctor
before receiving BUTRUM 2MG INJECTION.

Is it safe to drive while receiving BUTRUM 2MG INJECTION?

Do not drive or operate machines after receiving BUTRUM 2MG INJECTION since it
impairs the mental and/or physical abilities to drive or operate machinery.
Consult your doctor before receiving BUTRUM 2MG INJECTION.

Is BUTRUM 2MG INJECTION safe to be used in children and elderly patients?

No, BUTRUM 2MG INJECTION is not recommended to be used in children and
adolescents (aged below 18 years) it should be used with caution in elderly
patients (aged above 65 years) after consulting the doctor.

HowBUTRUM 2MG INJECTION works?

BUTRUM 2MG INJECTION works by blocking certain receptors (responsible for pain)
in the brain and spinal cord which leads to blockage of pain transmission thus
providing relief from moderate to severe acute pain in affected individuals.

How BUTRUM 2MG INJECTION is administered?

BUTRUM 2MG INJECTION will be given to you only by a doctor or a nurse into the
vein as an intravenous injection or into the muscle as an intramuscular
injection. Your doctor will decide the correct dose and duration for you
depending on your age, body weight and disease condition.