Basalog Refil Cartridge 1X3ml

Introduction About BASALOG REFIL CARTRIDGE

BASALOG REFIL CARTRIDGE contains Insulin glargine, which belongs to the group of
medicines called Antidiabetics. It is used in adults to manage diabetes
mellitus, a disease where the body does not produce enough insulin to control
the level of blood sugar, resulting in high blood sugar levels. Symptoms include
increased thirst, frequent urination, extreme hunger, unexplained weight loss,
fatigue, irritability, blurred vision, slow-healing sores, frequent infections,
and increased ketone levels in urine.

Your doctor might want you to make certain lifestyle changes, like eating a
healthy diet, not skipping meals, maintaining your weight, quitting alcohol and
smoking, and exercising regularly. Before management, your doctor might want to
take certain blood tests to understand your existing condition.

Before receiving BASALOG REFIL CARTRIDGE, inform your doctor if you have low
blood sugar, kidney, liver, or heart problems, or diabetic ketoacidosis. Avoid
drinking alcohol while receiving BASALOG REFIL CARTRIDGE. Inform your doctor if
you are pregnant or breastfeeding before receiving BASALOG REFIL CARTRIDGE. The
safety and effectiveness of BASALOG REFIL CARTRIDGE in children have yet to be
determined.

The most common side effects of receiving BASALOG REFIL CARTRIDGE are low blood
sugar (hypoglycemia), weight gain, and allergic reactions, including reactions
at the injection site. If your symptoms do not improve, see your doctor.

Uses Of BASALOG REFIL CARTRIDGE

• To manage diabetes mellitus in adults

How BASALOG REFIL CARTRIDGE Works

BASALOG REFIL CARTRIDGE lowers the blood glucose, facilitated by increased
protein synthesis and uptake of glucose, following the binding of insulin to
receptors on muscle and fat cells and then inhibiting glucose output from the
liver.

How to use BASALOG REFIL CARTRIDGE

BASALOG REFIL CARTRIDGE will be given to you only by a doctor or a nurse under
the skin (subcutaneously, usually thighs, upper arm, or abdomen). Your doctor
will decide the right dose and duration depending on your age, body weight, and
disease condition.

Side Effects Of BASALOG REFIL CARTRIDGE

Common

• low blood sugar (hypoglycemia)
• weight gain
• allergic reactions to skin
• skin thickening or pits at the injection site (lipodystrophy)

Stop receiving BASALOG REFIL CARTRIDGE and contact your doctor immediately if
you experience any of the following side effects:

• severe low blood sugar (hypoglycemia) (showing symptoms of dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, and hunger)
• severe allergic reaction (whole body reaction, a rash over your whole body, trouble breathing, a fast heartbeat, or sweating)
• low potassium in your blood (hypokalemia)
• heart failure (symptoms of shortness of breath, swelling of your ankles or feet, sudden weight gain)
• trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, and confusion

Warning & Precautions

!### Pregnancy

Consult your doctorIf you are pregnant, think you may be pregnant, or are planning to have a baby,
ask your doctor for advice before receiving BASALOG REFIL CARTRIDGE, as it is
unknown if it will harm the unborn baby. It will be given only if the benefits
outweigh the risk to the fetus and mother.

!### Breastfeeding

Use with CautionBASALOG REFIL CARTRIDGE should be used with caution in breastfeeding women as it
is not known if it is excreted in breast milk. Inform your doctor before
receiving this, and the dose will be adjusted by your doctor.

!### Driving and Using Machines

Use with CautionDo not drive or use machines while receiving BASALOG REFIL CARTRIDGE, as your
blood sugar can be low or high and your concentration and ability to react might
be affected. Consult your doctor if you have frequent episodes of hypoglycemia.

!### Alcohol

Consult your doctorAvoid consum
raise or lower your blood sugar levels.

!### Kidney

Use with CautionBASALOG REFIL CARTRIDGE should be used with caution in patients with kidney
disease. Your dose will be adjusted depending on your age, body weight, and
disease condition. Consult your doctor before receiving BASALOG REFIL CARTRIDGE.

!### Liver

Use with CautionBASALOG REFIL CARTRIDGE should be used with caution in patients with liver
disease. Your dose will be adjusted depending on your age, body weight, and
disease condition. Consult your doctor before receiving it.

!### Allergy

ContraindicatedBefore receiving BASALOG REFIL CARTRIDGE, inform your doctor if you are allergic
to insulin, glargine, or any of the other ingredients in this medicine.

!### Heart Disease

Use with CautionBASALOG REFIL CARTRIDGE should be used with caution in patients with heart
failure, stroke, or other heart problems. Consult your doctor before receiving
BASALOG REFIL CARTRIDGE.

!### Use In Pediatrics

Consult your doctorThe safety and effectiveness of BASALOG REFIL CARTRIDGE in children have not
been established yet. Consult your doctor before receiving it.

!### Use In Geriatrics

Use with CautionBASALOG REFIL CARTRIDGE should be used with caution in patients over 65 years of
age. The dose will be adjusted, and regular blood and kidney tests will be
conducted. Consult your doctor before receiving BASALOG REFIL CARTRIDGE.

Others

BASALOG REFIL CARTRIDGE is not recommended for use if you:

• have diabetic ketoacidosis
• had an episode of low blood sugar

Interactions

A. Drug-Drug interactions:

Before receiving BASALOG REFIL CARTRIDGE, inform your doctor if you are taking
any of the following medicines:

• other medicines for the management of diabetes (metformin, repaglinide, glucagon, pioglitazone, etc.)
• monoamine oxidase inhibitors (MAOI) (used to manage depression) (phenelzine, selegiline)
• medicines used to manage high blood pressure and heart conditions Ex. metoprolol, atenolol, clonidine, guanethidine, reserpine, chlorothiazide, diazoxide, benazepril, captopril, disopyramide
• salicylates (used to relieve pain and lower fever) (aspirin, pentoxifylline, propoxyphene)
• sulphonamides (used to manage infections) (Ex. bactrim, cotrim)
• oral contrace
• somatostatin analogues (Ex. octreotide)
• glucocorticoids (such as ‘cortisone’ used to manage inflammation)
• thyroid hormones (used to manage thyroid gland disorders)
• growth hormone (medicine for stimulation of skeletal and somatic growth and pronounced influence on the body’s metabolic processes like somatropin)
• danazol (a medicine acting on ovulation)
• niacin used to manage cholesterol levels
• fluoxetine (used to manage depression)
• fibrates (used to lower high levels of blood lipids)
• diuretics (used to manage high blood pressure or excessive fluid retention)
• glucagon (a pancreatic hormone used to manage severe hypoglycemia)
• isoniazid (used to manage tuberculosis)
• phenothiazine derivatives, lithium salts (used to manage psychiatric disorders), and atypical antipsychotic medicines (such as olanzapine and clozapine)
• sympathomimetic medicines (such as epinephrine, salbutamol, and terbutaline used to manage asthma)
• protease inhibitors Ex. darunavir, indinavir (used to manage HIV)
• pentamidine (used to manage some infections caused by parasites)

Overdosage:

BASALOG REFIL CARTRIDGE will be administered to you only by a doctor or a nurse
in a hospital, so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms of low blood sugar or
hypokalemia (low potassium levels in the blood)

Synopsis

Drug	:	Insulin glargine
Pharmacological Category	:	Antidiabetic
Therapeutic Indication	:	Diabetes mellitus
Dosage Forms	:	Injection, Cartridge, Kit, Prefilled pen, Prefilled syringes

More Information

• Keep BASALOG REFIL CARTRIDGE out of reach of children
• Store in a refrigerator (2-8°C)

FAQs About BASALOG REFIL CARTRIDGE

Q: What is BASALOG REFIL CARTRIDGE used for?

A: BASALOG REFIL CARTRIDGE is used to manage diabetes mellitus in adults, a
disease where the body does not produce enough insulin to control the level of
blood sugar, resulting in high blood sugar levels.

Q: What should I do if I experience low blood sugar during management with BASALOG REFIL CARTRIDGE?

A: Take glucose tablets or high-sugar snacks (sweets, biscuits, fruit juice) if
you experience low blood sugar while taking BASALOG REFIL CARTRIDGE. Measure
your blood sugar and rest. Carry glucose tablets or sugar snacks with you in
case of emergencies.

Q: Can I receive BASALOG REFIL CARTRIDGE during pregnancy?

A: If you are pregnant, think you may be pregnant, or are planning to have a
baby, ask your doctor for advice before receiving BASALOG REFIL CARTRIDGE, as it
is unknown if it will harm the unborn baby. It will be given only if the
benefits outweigh the risks to the fetus and mother.

Q: Can BASALOG REFIL CARTRIDGE be used in patients with kidney and liver problems?

A: BASALOG REFIL CARTRIDGE should be used with caution in patients with liver
and kidney disease. Your dose will be adjusted depending on your age, body
weight, and disease condition. Consult your doctor before receiving it.

Q: How does BASALOG REFIL CARTRIDGE work?

A: BASALOG REFIL CARTRIDGE lowers blood glucose levels due to the facilitated
uptake of glucose following the binding of insulin to receptors on muscle and
fat cells, inhibiting glucose output from the liver. Your doctor might also want
you to make certain lifestyle changes, like eating a healthy diet, not skipping
meals, maintaining your weight, quitting alcohol and smoking, and exercising
regularly.

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care