Zyle 300mg Tablet 10'S

Introduction About ZYLE 300MG TABLET

ZYLE 300MG TABLET contains Allopurinol which belongs to a group of medicines
called Enzyme inhibitors. It is used to manage gout, kidney stones, enzyme
disorders (Lesch-Nyhan Syndrome), and high levels of uric acid caused by certain
cancer medications.

Gout is a form of arthritis due to high levels of uric acid in the body and this
uric acid builds up in the joints and tendons as crystals causing severe pain,
redness and tenderness in joints.

Before taking ZYLE 300MG TABLET, inform your doctor if you have kidney or liver
problems, high blood pressure or heart problems, thyroid, cancer or Lesch-Nyhan
syndrome, gout attack, lactose or galactose intolerance and glucose-galactose
malabsor

ZYLE 300MG TABLET should be used with caution in pregnant women and it is not
recommended for use in breastfeeding women as it passes through the breast milk.
Consult your doctor before taking it.

ZYLE 300MG TABLET is not recommended for use in children below children under 15
years of age except in some types of cancer such as leukaemia and certain enzyme
disorders such as Lesch-Nyhan syndrome. ZYLE 300MG TABLET should be used with
caution in elderly patients above 65years of age. Consult your doctor before
taking it.

The most common side effects of taking ZYLE 300MG TABLET are skin rash and
increased levels of thyroid stimulation hormone in blood. Consult with your
doctor if any of these worsens or doesn’t improve.

Uses Of ZYLE 300MG TABLET

Manages,

• gout
• kidney stones formation
• certain types of kidney diseases
• some types of cancer (especially leukemia)
• Lesch-Nyhan syndrome

How ZYLE 300MG TABLET Works

ZYLE 300MG TABLET works by stopping the enzyme (xanthine oxidase) which is
responsible for production of uric acid. Thus lowering the levels of uric acid
in blood and urine and decreases the incidence of gout symptoms.

How to use ZYLE 300MG TABLET

Take ZYLE 300MG TABLET as advised by your physician. Swallow the medicines with
a glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of ZYLE 300MG TABLET

Common

• skin rash
• increased thyroid-stimulating hormone levels in the blood.

Uncommon

• nausea, vomiting
• diarrhoea
• abdominal pain
• abnormal liver tests

Rare

• liver problems (liver inflammation, jaundice)

Stop taking ZYLE 300MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• allergic reaction symptoms such as flaking skin, boils or sore lips and mouth, sudden wheeziness, fluttering or tightness in the chest and collapse
• serious hypersensitivity reactions characterised by fever, joint pain, abnormalities in blood, bleeding in the lips, mouth, eyes, nose or genitals, ulcers of the mouth, throat, nose, genitals, conjunctivitis (red and swollen eyes), widespread blisters or peeling

How To Manage Side Effects

Itchy rash:

Avoid hot showers because hot water can irritate the skin. Do not scratch the
affected area. Use sunscreen and protective clothing when outdoors. Regularly
use moisturizer to soothe and hydrate the affected area. If the symptom does not
improve, contact your doctor.

Nausea or vomiting:

Try to take this medicine with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food. If the symptom does not improve, contact
your doctor.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not
take any medicine on your own for managing diarrhea. Contact your doctor if the
symptom did not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller meals. Keep a heat
pad on your stomach. Do not self-manage and contact your doctor if the symptom
did not improve.

Warning & Precautions

!### Pregnancy

ZYLE 300MG TABLET should be used with caution in pregnant women. Consult with
your doctor before taking.

!### Breastfeeding

ZYLE 300MG TABLET is not recommended for use in breastfeeding women as it passes
through the breast milk. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel drowsy, giddy or have problems
with co-ordination after taking ZYLE 300MG TABLET.

!### Kidney

ZYLE 300MG TABLET should be used with caution in patients with kidney problems.
Consult your doctor before taking.

!### Liver

ZYLE 300MG TABLET should be used with caution in patients with liver problems.
Consult your doctor before taking.

!### Allergy

Do not take ZYLE 300MG TABLET if you are allergic to Allopurinol or any other
ingredients of this medicine.

!### Heart Disease

ZYLE 300MG TABLET should be used with caution in patients with heart problems.
Consult your doctor before taking.

Others

Before taking ZYLE 300MG TABLET inform your doctor if you have:

• Lesch-Nyhan syndrome
• thyroid problems
• high blood pressure
• an acute attack of gout
• cancer (especially leukaemia)
• intolerance to some sugars

Use in paediatrics:

ZYLE 300MG TABLET is not recommended in children below 15 years of age except in
some types of cancer (leukaemia) and certain enzyme disorders such as
Lesch-Nyhan syndrome. Consult with your child’s doctor before giving it to your
child.

Use in geriatrics:

ZYLE 300MG TABLET should be used with caution in elderly patients (aged above 65
years). Consult your doctor before taking.

Interactions

A. Drug - Drug interactions:

Before taking ZYLE 300MG TABLET, inform your doctor if you are taking any of the
following medicine:

• aspirin (medicine used to manage heart diseases, pain)

• theophylline (medicine used for asthma and breathing disorders)

• medicines used to manage epilepsy (Ex. phenytoin, carbamazepine).

• vidarabine (used to manage herpes simplex or chicken pox)

• medicines used to manage bacterial infections (Ex. ampicillin and amoxicillin)

• didanosine (used to manage HIV infection)

• medicines used to manage diabetes (Ex. chlorpropamide and tolbutamide)

• cytostatics (medicines stop the cell growth in cancer). Ex. cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkyl halogenides

• azathioprine (medicines used for rheumatoid arthritis and after organ transplants)

• medicines used to manage high blood pressure, heart failure (Ex. captopril)

• medicines used to thin the blood (Ex. dicoumarol, phenprocoumon, and warfarin)

• medicines used to reduce uric acid levels, gout (Ex. probenecid, salicylate).

• aluminium hydroxide (medicines used to manage acidity)

Overdosage:

If you or anyone else accidentally take too much of ZYLE 300MG TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
nausea, vomiting, diarrhoea and dizziness.

Synopsis

Drug	:	Allopurinol
Pharmacological Category	:	Xanthine Oxidase Inhibitor
Therapeutic Indication	:	Gout, Kidney stones, Leukaemia, Lesch-Nyhan syndrome
Dosage Forms	:	Tablet, Capsule

More Information

• Keep ZYLE 300MG TABLET out of the sight and reach of children
• Store ZYLE 300MG TABLET below 25°C

FAQs About ZYLE 300MG TABLET

How ZYLE 300MG TABLET works?

ZYLE 300MG TABLET works by stopping the enzyme (xanthine oxidase) which is
responsible for production of uric acid. Thus, lowering the levels of uric acid
in blood and urine and decreases the incidence of gout symptoms.

Does ZYLE 300MG TABLET affect kidney?

Yes. ZYLE 300MG TABLET might affect the kidney. Inform your doctor priorly if
you have any kidney diseases or are on dialysis. Your doctor might consider
adjusting the dose of ZYLE 300MG TABLET for you. Consult your doctor before
taking

What happens if I suddenly stop taking ZYLE 300MG TABLET?

Do not stop ZYLE 300MG TABLET unless you told by doctor. If you stop taking ZYLE
300MG TABLET suddenly, there is a high risk of gout attack or you will get
serious side effects. Consult your doctor before stopping.

Can ZYLE 300MG TABLET cause joint pain?

Yes. ZYLE 300MG TABLET can cause joint pain. But it is a rare side effect. If
you develop any of these symptoms stop the medication and contact your
healthcare
provide.

Does ZYLE 300MG TABLET affect my ability to drive?

Do not drive or operate any machines if you feel drowsy, giddy or have problems
with co-ordination after taking ZYLE 300MG TABLET. You can resume with your
activities after you feel normal again.

If I am having a gout attack, will an extra dose of ZYLE 300MG TABLET help
me?

No. ZYLE 300MG TABLET is not a pain reliever and does not show its effect
immediately. If you have an attack of gout while taking ZYLE 300MG TABLET, keep
taking it at the same dose. Do not stop taking it. Your doctor may advise you to
take a pain reliever medicine You can also apply icepacks or cold compress and
rest the affected joint, to reduce pain. See your doctor if the pain and
inflammation does not show improvement in 24 hours.

Useful Diagnostic Tests

• Creatinine Levels
• Uric acid
• Kidney Function Tests