ZONA 0.5 Tablet 10's

Introduction About ZONA 0.5 TABLET

ZONA 0.5 TABLET contains Clonazepam which belongs to the group of medicines
known as Benzodiazepines. It is used to manage seizure disorder (epilepsy) in
adults and children and p
(agoraphobia) in adults.

Epilepsy is a common condition affecting the brain and causes frequent fits or
seizures (bursts of electrical activity in the brain). Symptoms include
uncontrollable jerking or shaking, loss of consciousness or collapsing. P
disorder is characterized by sudden occurrence of p

During the therapy with ZONA 0.5 TABLET, your doctor may conduct a blood test to
determine liver function. Do not consume alcohol while taking ZONA 0.5 TABLET as
it may provoke seizures or fits and may worsen side effects which may possibly
lead to severe sedation.

ZONA 0.5 TABLET is not recommended for use in patients with myasthenia gravis,
acute narrow-angle glaucoma, sleep apnoea, lung diseases and breathing problems
and severe liver diseases. Consult your doctor before taking it.

ZONA 0.5 TABLET should be taken with caution in patients with mild to moderate
liver disease, severe kidney disease, low blood pressure, depression, psychosis
and schizophrenia. Consult your doctor before taking it.

ZONA 0.5 TABLET is not recommended for use in pregnant women unless considered
clearly necessary. Consult your doctor before taking it. ZONA 0.5 TABLET is
generally not recommended for use in breastfeeding women unless considered
clearly necessary as it may pass through the breast milk. Consult your doctor
before taking it.

ZONA 0.5 TABLET should be used with caution in children and elderly patients.
Consult your doctor before taking it.

Some specific serious side effects of ZONA 0.5 TABLET include suicidal thoughts
or thoughts of self-harming or unusual changes in behaviour or mood. If you have
these thoughts, contact your doctor immediately.

The most common side effects of taking ZONA 0.5 TABLET are drowsiness,
dizziness, problems with walking and coordination, depression, fatigue, and
problems with memory. Contact your doctor in case any of the symptoms worsen.

Uses Of ZONA 0.5 TABLET

Used to manage

• seizures disorders
• p

How ZONA 0.5 TABLET Works

ZONA 0.5 TABLET belongs to benzodiazepines which work by enhancing the activity
of GABA (gamma-aminobutyric acid) an inhibitory neurotransmitter (a chemical in
the brain).

How to use ZONA 0.5 TABLET

Take ZONA 0.5 TABLET as advised by your physician. It can be taken with or
without meals.

For Tablet, Capsule: Swallow the medicine with a glass of water. Do not
crush or chew the medicine.

For Dispersible Tablet: Disperse the medicine in the specified quantity of
water as mentioned on the label. Consume the medicine immediately after
reconstitution.

For Mouth Dissolving Tablet, Orally Disintegrating Tablet: Place the
medicine inside your mouth and let it dissolve completely. Do not swallow or
chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you
depending on your age, body weight and disease condition. Continue to take this
medicine for the stipulated duration prescribed by your doctor to achieve better
results.

Side Effects Of ZONA 0.5 TABLET

Common

• sedation, drowsiness, dizziness
• problems with walking and coordination
• depression
• fatigue, lethargy
• problems with memory

Uncommon

• blurred vision
• confusion
• irritability
• loss of libido
• lack of motivation
• psychomotor agitation
• worsening of depression
• short-term memory loss, anterograde amnesia (a type of memory loss)

Rare

• nausea, stomach problems
• hives, rash
• hair loss
• change in skin colour
• urinary incontinence
• rage and impulsive behaviour

Stop taking ZONA 0.5 TABLET and contact your physician immediately if you
experience any of the following side effects:

• severe allergic reactions such as skin rash, itching, sudden swelling of the hands, feet and ankles, sudden swelling of the throat, face, lips and mouth causing difficulty in breathing or swallowing
• breathlessness, swelling of the ankles, cough, tiredness, palpitations, chest pain which may spread to the neck and shoulders and to the left arm
• symptoms of being aggressive, restlessness, hyperactive, irritability, nervousness, agitated, hostile or anxious
• problems with sleep, nightmares and abnormal dreams
• mental problems such as seeing or hearing things that are not really there (hallucinations), psychoses, vivid dreams, acute rage, delusions (believing in things that are not real) and problems with your speech
• inappropriate behaviour, emotional and mood changes
• types of fits
• self-harming thoughts
• new or worse depression and anxiety
• p
• acting on dangerous impulses
• extreme increase in activity and talking (m

How To Manage Side Effects

Nausea:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food. Contact your doctor if nausea worsens.

Stomach pain:

Try to rest and relax. Eat small meals but take them frequently. Keep a heating
pad on your stomach. Contact your doctor if the stomach pain does not improve.

Dizziness:

Lie down or sit down while you feel dizzy. Avoid driving or operating any
machinery until you feel fine. If the symptom persists after a week or so,
contact your doctor.

Warning & Precautions

!### Pregnancy

ZONA 0.5 TABLET is generally not recommended for use in pregnant women unless
considered clearly necessary. Consult your doctor before taking it.

!### Breastfeeding

ZONA 0.5 TABLET is generally not recommended for use in breastfeeding women as
it may pass through the breast milk and may cause drowsiness and feeding
difficulties. Consult your doctor before taking it.

!### Driving and Using Machines

ZONA 0.5 TABLET may cause drowsiness or sleepiness which can affect your ability
to drive and operate machines. Do not drive or operate any machines while taking
ZONA 0.5 TABLET.

!### Alcohol

Do not consume alcohol while taking ZONA 0.5 TABLET as it may provoke seizures
or fits and may worsen side effects possibly leading to serve sedation.

!### Kidney

ZONA 0.5 TABLET should be used with caution in patients with severe kidney
disease. Consult your doctor before taking it.

!### Liver

ZONA 0.5 TABLET is not recommended for use in patients with severe liver
disease. It should be used with caution in patients with mild to moderate liver
disease. Consult your doctor before taking it.

!### Allergy

Do not take ZONA 0.5 TABLET if you are allergic to Clonazepam or to other
Benzodiazepines or to any other ingredients of this medicine.

!### Lungs

ZONA 0.5 TABLET is not recommended for use in patients with lung diseases and
breathing problems. It should be used with caution in patients with mild to
moderate lung disease. Consult your doctor before taking it.

!### Heart Disease

ZONA 0.5 TABLET should be used with caution in patients suffering from low blood
pressure. Consult your doctor before taking it.

Others

ZONA 0.5 TABLET is not recommended for use if you:

• suffer from myasthenia gravis (condition in which there is a varying degree of muscle weakness)
• suffer from narrow-angle glaucoma (increased pressure inside eye leading to damage of o
• suffer from sleep apnoea syndrome (sleep-related breathing disorder)
• have rare hereditary problems such as galactose intolerance, Lapp lactase deficiency and glucose-galactose malabsor

Before taking ZONA 0.5 TABLET inform your doctor if you:

• suffer from depression, psychosis and schizophrenia (mental disorders)
• suffer from porphyria (blood disorder)
• suffer from spinal or cerebral ataxia (condition in which you are shaky, unsteady, have slurred speech and rapid eye movements)
• suffer from amnesia (memory impairment)
• suffer from ataxia
• have an operation or dental management
• have hypersalivation

Use in pediatrics:

Your doctor will prescribe the right dose depending on your child’s age, body
weight and disease condition. Safety and effectiveness for children and
adolescents below 18 years of age with p
Consult your doctor before taking ZONA 0.5 TABLET.

Use in geriatrics:

ZONA 0.5 TABLET should be taken with caution by elderly patients. Your doctor
will prescribe the right dose depending on age, body weight and disease
condition. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking ZONA 0.5 TABLET inform your doctor if you are taking any of the
following medicine:

• carbamazepine, phenobarbital, phenytoin, primidone, sodium valproate, lamotrigine, hydantoins (used for the management of seizures and fits)
• cimetidine (medicine used for management of acidity and stomach ulcers)
• ramipril, candesartan, amlodipine, doxazosin (medicines used for management of high blood pressure)
• diazepam, lorazepam, alprazolam (medicines used to manage anxiety or to produce sleep)
• non-steroidal anti-inflammatory drugs (medicines used for pain management)
• fluconazole (medicine used for fungal infections)
• rifampicin (medicine used for tuberculosis)
• lithium (medicine used for mental illness)
• amitriptyline, nortriptyline, phenelzine, isocarboxazid (medicines used for depression)
• chlorpromazine, fluphenazine (medicines used to manage psychoses)
• baclofen (medicine used to relax muscles)
• diphenhydramine (medicine used to manage allergies)
• morphine, codeine (medicines used for severe pain)
• halothane (medicine used for anaesthesia)
• disulfiram (medicine used for alcohol withdrawal)
• atropine (medicine used to manage low heartbeat)

Overdosage:

If you or anyone else accidentally takes too much of ZONA 0.5 TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdosage
range from mild symptoms such as sleepiness, light headedness, drowsiness,
confusion, lethargy, less responsive than normal and serious symptoms such as
uncoordinated body movements, dysarthria (slurred speech), hypotonia,
respiratory depression, low blood pressure, nystagmus (rapid eye movements).

Synopsis

Drug	:	Clonazepam
Pharmacological Category	:	Benzodiazepines
Therapeutic Indication	:	Epilepsy, P
Dosage Forms	:	Tablet, Injection, Dispersible tablet, Oral disintegrating strips

More Information

• Keep ZONA 0.5 TABLET out of sight and reach of children
• Store at room temperature

FAQs About ZONA 0.5 TABLET

Is ZONA 0.5 TABLET a sleeping Pill?

No, ZONA 0.5 TABLET is used to manage epilepsy and p
without fear of open spaces (agoraphobia).

What happens when you take ZONA 0.5 TABLET?

ZONA 0.5 TABLET works by increasing levels of a calming chemical called GABA in
your brain. This can help to relieve anxiety, and fits or relax tense muscles.

What are the common side effects of ZONA 0.5 TABLET?

The most common side effects of taking ZONA 0.5 TABLET aredrowsiness,
dizziness,problems with walking and coordination,depression, fatigue, and
problems with memory. Contact your doctor if the symptoms worsen.

Who should not take ZONA 0.5 TABLET?

ZONA 0.5 TABLET is not recommended for use in patients with myasthenia gravis,
acute narrow-angle glaucoma, sleep apnoea, lung diseases and breathing problems
and severe liver diseases. Consult your doctor before taking it.

For how long should I take ZONA 0.5 TABLET?

The duration of management with ZONA 0.5 TABLET as per the doctor's advice. Your
doctor will evaluate you after 4 weeks of management in order to assess the need
for continuation of management, especially if you do not have any symptoms.
Consult your doctor for advice.