ZAYO 50 Tablet 10's

Introduction About ZAYO 50 TABLET

ZAYO 50 TABLET is a combination of Sacubitril and Valsartan which belongs to the
group of medicines called Angiotensin receptor neprilysin inhibitors. ZAYO 50
TABLET is indicated to reduce the risk of cardiovascular death and
hospitalization for heart failure in patients with chronic heart failure (New
York Heart Association Class II-IV) and reduced ejection fraction.

Heart failure occurs when the heart is weak and cannot pump enough blood to the
lungs and to the rest of the body and it is characterized by symptoms such as
breathlessness, fatigue, tiredness and ankle swelling. Before taking ZAYO 50
TABLET inform your doctor if you have liver, kidney or heart problems. ZAYO 50
TABLET is not recommended for use in pregnant and breast-feeding women. It is
not suitable for use in children and adolescents under 18 years of age and it
should be used with caution in elderly patients (65 years of age and above).

Before taking ZAYO 50 TABLET inform your doctor about previous allergy and
medication history to manage any serious effect. The most common side effects of
taking ZAYO 50 TABLET are dizziness, cough, headache, tiredness, nausea and
weakness. Consult your doctor if any of the side effects worsen.

Uses Of ZAYO 50 TABLET

• Manages long-term heart failure in adults

How ZAYO 50 TABLET Works

ZAYO 50 TABLET helps to manage long-term heart failure, where sacubitril works
by relaxing and widening the blood vessels and makes it easier for the heart to
pump blood throughout the body and valsartan works by relaxing the blood vessels
by blocking a substance called angiotensin-II (causing blood vessels to tighten)
which is produced in the body and thus lowers the blood pressure.

How to use ZAYO 50 TABLET

Take ZAYO 50 TABLET as advised by your physician. Swallow ZAYO 50 TABLET with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose and duration for you depending upon your age, body weight and
disease condition.

Side Effects Of ZAYO 50 TABLET

Common

• Dizziness, light-headedness (low blood pressure)
• Signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness)
• Decrease in renal function
• Cough
• Diarrhoea
• Signs of low red blood cells (anemia)
• Tiredness, weakness
• Headache
• Fainting or spinning sensation
• Nausea
• Inflammation of lining of the stomach (stomach pain, nausea)
• Signs of low sugar levels in the blood (fast heartbeat, sweating, nervousness or anxiety)

Uncommon

• Allergic reaction with rash and itching
• Dizziness when switching from sitting to standing position

Rare

• Hallucinations
• Changes in sleeping pattern

Stop taking ZAYO 50 TABLET and contact your doctor immediately if you experience
any of the following side effects:

• Severe allergic reactions (swelling of the face, lips, tongue or throat, which may cause difficulties in breathing or swallowing (angioedema))

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom did not improve.

Headache

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the forehead if required. Do not consume too much of
alcohol. Consult your doctor if the symptom did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform
any strenuous activities immediately after eating. Consult your doctor if the
symptom did not improve.

!### Tiredness

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular
minimal exercise and follow regular sleep schedule. Consult your doctor if your
symptom did not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedZAYO 50 TABLET is not recommended for use in early pregnancy and must not be
used in pregnant women when more than 3 months pregnant, as it may cause serious
harm to the baby. Consult your doctor before taking ZAYO 50 TABLET if you think
you may be pregnant.

!### Breastfeeding

ContraindicatedZAYO 50 TABLET is not recommended for use in breastfeeding women. Consult your
doctor before taking ZAYO 50 TABLET if you are breast-feeding or about to start
breast-feeding.

!### Driving and Using Machines

Use with CautionAvoid driving or handling any machines while taking ZAYO 50 TABLET because it
may cause dizziness or tiredness.

!### Kidney

Use with CautionZAYO 50 TABLET should be used with caution in patients with severe kidney
disease and with narrowed kidney artery. Consult your doctor before taking ZAYO
50 TABLET.

!### Liver

Consult your doctorZAYO 50 TABLET is not recommended for use in patients with severe liver disease
and it should be used with caution in patients with liver disease. Consult your
doctor before taking ZAYO 50 TABLET.

!### Allergy

ContraindicatedDo not take ZAYO 50 TABLET if you are allergic (hypersensitive) to Sacubitril
and Valsartan.

!### Use In Pediatrics

ContraindicatedZAYO 50 TABLET is generally not recommended for use in children and adolescents
(under 18 years of age). Consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionZAYO 50 TABLET should be used with caution in elderly patients (above 65 years
of age). Consult your doctor before taking ZAYO 50 TABLET.

Others

ZAYO 50 TABLET is not recommended for use, if you have:

• Diabetes or impaired kidney function (and being managed with aliskiren (blood pressure lowering medicine))
• Personal or family history of angioedema (when taking angiotensin receptor blockers (ARB) such as valsartan, telmisartan)

Before taking ZAYO 50 TABLET inform your doctor if you have:

• History of angioedema
• Low blood pressure
• Vomiting or diarrhea
• Dehydration
• Hallucinations, paranoia or changes in sleeping pattern

Interactions

A. Drug-Drug interactions:

Before taking ZAYO 50 TABLET inform to your doctor, if you are taking any of
these medicines:

• Enalapril, lisinopril or ramipril (manages high blood pressure)
• Aliskiren and angiotensin receptor blockers such as telmisartan, losartan (manages heart failure)
• Atorvastatin (lowers high cholesterol levels)
• Sildenafil (manages erectile dysfunction or lung hypertension)
• Potassium supplements, salt substitutes containing potassium, potassium-sparing medicines such as spironolactone (used to increase potassium levels in blood)
• Heparin, warfarin (manages blood clot)
• Non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen, indomethacin or selective cyclooxygenase-2 (Cox-2) inhibitors such as celecoxib (manages pain and inflammation)
• Lithium (used to manage psychiatric illness)
• Furosemide (used to increase the amount of urine)
• Nitroglycerine (manages angina pectoris)
• Rifamycin (manages bacterial infections)
• Ciclosporin (used to manage rejection of transplanted organs)
• Ritonavir (used to manage HIV/AIDS)
• Metformin (manages diabetes)

Overdosage:

If you or anyone else accidentally take too much of ZAYO 50 TABLET, contact your
doctor immediately or go to a nearest hospital straight away. Overdosage
symptoms of ZAYO 50 TABLET includes severe dizziness and fainting.

Synopsis

Drug	:	Sacubitril and Valsartan
Pharmacological Category	:	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Indication	:	Heart failure
Dosage Forms	:	Tablet

More Information

Storage

• Keep out of reach of children
• Do not store above 30°C

FAQs About ZAYO 50 TABLET

Q: What is ZAYO 50 TABLET used for?

A: ZAYO 50 TABLET is indicated to reduce the risk of cardiovascular death and
hospitalization for heart failure in patients with chronic heart failure (New
York Heart Association Class II-IV) and reduced ejection fraction.

Q: What are the common side effects of taking ZAYO 50 TABLET?

A: The most common side effects of taking ZAYO 50 TABLET are dizziness,
light-headedness (low blood pressure), signs of high levels of potassium in the
blood (irregular heartbeat, muscle weakness), decrease in renal function, cough,
diarrhea, signs of low red blood cells (anemia), tiredness, headache, fainting
or spinning sensation. Consult your doctor immediately if any of the side
effects worsen.

Q: Can ZAYO 50 TABLET be used in pregnant women?

A: No. ZAYO 50 TABLET is not recommended for use in early pregnancy and must not
be used in pregnant women when more than 3 months pregnant, as it may cause
serious harm to the baby. Consult your doctor before taking ZAYO 50 TABLET if
you think you may be pregnant.

Q: Is ZAYO 50 TABLET safe to use in liver disease patients?

A: ZAYO 50 TABLET is not recommended for use in patients with severe liver
disease and it should be used with caution in patients with liver disease.
Consult your doctor before taking ZAYO 50 TABLET.

Q: What to do If I forget to take ZAYO 50 TABLET?

A: You should take ZAYO 50 TABLET immediately when you remember. If it is time
for your next dose skip the missed dose and follow your regular dose schedule.
Do not double the dose to match up your missed dose.