VONARIL Injection 1's

Introduction About VONARIL INJECTION

VONARIL INJECTION is used to provide relief from sensation of nausea and
vomiting. It contains a medicine called Ondansetron which is an anti-emetic
medicine. It reduces the nausea and vomiting sensation by blocking the vomiting
centres of the brain.

Before receiving VONARIL INJECTION, inform your doctor if you have severe
constipation, heart or liver problems, imbalance with the levels of salts in the
blood, such as potassium, sodium and magnesium or if you have been scheduled for
any surgery.

Consult your doctor before taking VONARIL INJECTION if you are pregnant or
breastfeeding as a precaution.

The most common side effects of receiving VONARIL INJECTION includes headache,
flushing and constipation. Consult your doctor if any of these above symptoms
gets worse.

Uses Of VONARIL INJECTION

• Management of nausea and vomiting

How VONARIL INJECTION Works

VONARIL INJECTION is anti-emetic medicine which works by blocking the action of
serotonin, a natural substance in the body that can trigger nausea and vomiting.
Specifically, it targets the 5-HT3 receptors in the brain and the
gastrointestinal tract. By inhibiting these receptors, ondansetron effectively
reduces the signals that lead to nausea and vomiting, providing relief to
patients undergoing treatments that can induce these symptoms.

How to use VONARIL INJECTION

• VONARIL INJECTION will be given to you only by a doctor or a nurse, into a vein as an intravenous infusion, or into the muscles as intramuscular injection
• Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition

Side Effects Of VONARIL INJECTION

Common Side Effects of VONARIL INJECTION:

• headache
• flushing (feeling of warmth)
• constipation
• Dizziness
• Diarrhea
• fits (seizures)
• irregular heartbeat (fast or slow)
• low blood pressure
• hiccups

Stop receiving VONARIL INJECTION and contact your doctor if you experience any
of the following side effects:

• sudden wheezing, chest pain or tightness
• swelling of eyelids, face, lips, mouth or tongue
• skin rash, red spots or lumps under your skin (hives) or anywhere on the body

Warning & Precautions

!### Pregnancy

Consult your doctorPregnant women should only use VONARIL INJECTION if prescribed by a doctor,
after assessing the benefits and risks.

!### Breastfeeding

Consult your doctorLimited data is available on the use of ondansetron during breastfeeding. While
no harmful effects have been reported in breastfed infants, ondansetron is
excreted in breast milk. Therefore, breastfeeding mothers should consult a
doctor before using this medicine to ensure its safety for their baby.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy or uneasy after receiving
VONARIL INJECTION.

!### Liver

Use with CautionVONARIL INJECTION should be used with caution in patients with liver problems.
Consult your doctor before receiving VONARIL INJECTION.

!### Allergy

ContraindicatedDo not take VONARIL INJECTION if you are allergic to ondansetron, gr
palonosetron or to any other ingredients of this medicine.

!### Heart Disease

Use with CautionVONARIL INJECTION should be used with caution in patients with heart diseases
such as uneven heartbeats (arrhythmias) or congestive heart failure.

!### Use In Pediatrics

Monitoring requiredVONARIL INJECTION can be used in children if prescribed by the physician.

!### Use In Geriatrics

Monitoring requiredVONARIL INJECTION can be used in elderly patients if prescribed by the
physician.

Others

Before receiving VONARIL INJECTION, inform your doctor if you:

• have a blockage in your gut
• have constipation
• have problems with the levels of salts in the blood (such as potassium, sodium and magnesium)
• are intolerant to some sugars (Ex. lactose intolerance)

Interactions

A. Drug-Drug Interactions:

Before receiving VONARIL INJECTION, inform your doctor, if you are receiving any
of the following medicine:

• apomorphine (used to manage Parkinson’s disease)
• Antiepile
• Anti-TB agent (Ex. rifampicin)
• Pain killers (such as tramadol, methadone)
• Antipsychotic agents (Ex. haloperidol)
• Cardiac agents (Ex. amiodarone) and/or high blood pressure (Ex. atenolol, timolol)
• cancer medicines (Ex. doxorubicin, daunorubicin, monoclonal, trastuzumab)
• Antibiotics (such as erythromycin, ketoconazole)
• Antidepressants, Sedatives, Anxiolytics (ex. fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine escitalopram)

Overdosage:

If you or anyone else accidentally takes too much of VONARIL INJECTION, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ondansetron
Pharmacological Category	:	Serotonin antagonist
Therapeutic Indication	:	Nausea and Vomiting
Dosage Forms	:	Tablet, Injection, Dispersible Tablet, Syrup, Suspension, Oral strips, Lozenges, Pastille

FAQs About VONARIL INJECTION

Q: Is VONARIL INJECTION a chemo drug?

A: No, it is not a chemo drug. It belongs to a group of medicines called
serotonin antagonists and used to manage side effects caused due to
chemotherapy.

Q: What VONARIL INJECTION is used for?

A: VONARIL INJECTION is used to manage nausea and vomiting caused by medical
managements like chemotherapy, radiotherapy or surgery.

Q: For how long should you take VONARIL INJECTION?

A: Your doctor will advise you on how long you should continue to take VONARIL
INJECTION. Consult your doctor from time to time to review your management and
assess your symptoms.

Q: What happens if you take more VONARIL INJECTION than your required dose?

A: If you or anyone else accidentally takes too much of VONARIL INJECTION,
consult your doctor immediately or visit the nearby hospital.

Q: What side effects are seen with VONARIL INJECTION?

A: The most common side effects of receiving VONARIL INJECTION are headaches,
flushing (feeling of warmth), constipation. Consult your doctor if above side
effects got worse.

Useful Diagnostic Tests

• Complete blood count