TROPINE INJECTION 1ML

Introduction About TROPINE

TROPINE contains Atropine which belongs to the group of medicines called
Anti-cholinergic drugs. It is used to restore normal heartbeat during an event
of cardiac arrest (heart stops working suddenly). It is often used as a
preanesthetic medication to manage the risk of sudden decrease in heartbeat and
to reduce saliva secretions during surgical procedures. It can also be used in
the poisoning caused due to certain substances like insecticides or mushrooms.
It is used in combination with other medicines to reverse the effects of certain
muscle relaxants (like vecuronium, rocuronium) given during surgery. It can also
reduce the overactivity of certain medicines (muscle relaxants) used in the
management of severe muscle disorders like myasthenia gravis.

Atropine is an antimuscarinic agent. It works by blocking the effects of a
neurotransmitter called acetylcholine, which is responsible for causing
contraction of muscles, increase in body secretions, and decrease in heart rate.
As a result, it leads to stimulation of muscles, increase in heart rate, and
decrease in body secretions.

TROPINE is not recommended for use in patients suffering from closed-angle
glaucoma (increased eye pressure), an enlarged prostate, myasthenia gravis, or
any obstruction of gut. If you are pregnant or breastfeeding, consult your
doctor for advice before receiving TROPINE. The most common side effects of
TROPINE are dry mouth, reduced sweating, blurred vision, constipation, increased
heart rate and confusion. Consult your doctor if any of the symptom worsens.

Uses Of TROPINE

It is used:

• To restore normal heartbeat during emergency conditions like cardiac arrest
• As a preanesthetic medication to reduce salivary secretions
• To reverse the effect of muscle relaxants given during surgery
• To reduce the overactivity of certain medicines used to manage severe muscle disorders like myasthenia gravis
• As an antidote for insecticides and mushroom poisoning

How TROPINE Works

TROPINE is an antimuscarinic agent. It effectively restores cardiac activity and
body function by blocking the effects of a neurotransmitter called acetylcholine
in the body which is responsible for various physiological functions (such as
contraction of skeletal or smooth muscles, increase in body secretions or bowel
movements, and decrease in heart rate). As a result, TROPINE stimulates skeletal
muscles, increases heart rate and reduces body secretions (such saliva, sweat,
bronchial and intestinal secretion) and bowel movements. This helps in restoring
cardiac activity during fatal conditions like cardiac arrest or poisoning,
reduces salivary secretion during surgical procedures and stimulates muscle
movements by counteracting the effects of muscle relaxants.

How to use TROPINE

TROPINE will be given to you only by a doctor or a nurse either into the vein
(intravenously), muscle (intramuscularly), under the skin (subcutaneously) or
into the trachea (via endotracheal tube). Your doctor will decide the correct
dose and duration for you depending upon your age, body weight, and disease
condition.

Side Effects Of TROPINE

Common

• Dryness of mouth
• Blurred vision
• Inability to tolerate light (photophobia)
• Rapid heartbeat
• Flushing
• Constipation
• Difficulty with urination
• Decreased sweating

Rare

• Delirium (confused thinking and reduced awareness of surroundings)

Consult your doctor if you experience any of the following side effects:

• Signs of allergic reaction (such as skin rash, itching, blistering, and peeling of skin, swelling of the eyelids, face or lips, sudden wheeziness, or difficulty in breathing)

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and
drink plenty of water. Try to exercise more regularly. If you still feel
constipated, consult your doctor for advice.

!### Dry Mouth

Drink plenty of water and fruit juices. Consume soft foods with higher water and
fiber content. Artificial saliva can also be used in case of extreme dryness of
mouth. Consult your doctor if you experience dryness of mouth for prolonged
period.

Warning & Precautions

!### Pregnancy

Monitoring requiredTROPINE should not be used in pregnant women only if it is clearly necessary by
your doctor. Your doctor will prescribe TROPINE only if the benefits are greater
than any possible risk to the unborn baby. Therefore, consult your doctor before
receiving.

!### Breastfeeding

Monitoring requiredTROPINE should be used in breastfeeding mothers only if it is clearly necessary
by your doctor. Your doctor will prescribe TROPINE only if the benefits are
greater than any possible risk to the breastfeeding infant. Therefore, consult
your doctor before receiving.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if your ability is affected by TROPINE.

!### Alcohol

Consult your doctorAvoid consum
dizziness and drowsiness.

!### Kidney

Use with CautionTROPINE should be used with caution in patients with kidney diseases. Consult
your doctor before receiving.

!### Liver

Use with CautionTROPINE should be used with caution in patients with liver diseases. Consult
your doctor before receiving.

!### Allergy

ContraindicatedDo not receive TROPINE if you are allergic to Atropine.

!### Lungs

Use with CautionTROPINE should be taken with caution in patients having chronic pulmonary
disease (airflow to the lungs becomes restricted leading to cough and
breathlessness). Therefore, consult your doctor before receiving it.

!### Heart Disease

Use with CautionTROPINE should be used with caution in patients with heart diseases (such as
high blood pressure, fast or irregular heartbeat, angina, or heart failure) and
in patients who had a heart transplantation. Consult your doctor before
receiving.

!### Use In Pediatrics

Use with CautionTROPINE should be used with caution in children and adolescent (below 18 years),
especially if they suffer from fever or when surrounded by hot climate. Proper
dose adjustments and careful monitoring are required in such patients, as high
doses of TROPINE can cause CNS side effects.

!### Use In Geriatrics

Use with CautionTROPINE should be used with caution in elderly patients (65 years and above).
Consult your doctor before receiving.

Others

TROPINE is not recommended for use if you:

• Have myasthenia gravis (severe muscle weakness)
• Have toxic megacolon (swollen and inflamed colon causing stomach pain, bloating and fever)
• Have reflux esophagitis (inflammation of food pipe due to reflux of stomach acid)
• Have blockade or narrowing in the gut (ex. pyloric stenosis)
• Have paralytic ileus (paralysis of intestines that causes severe constipation and bloating)
• Have glaucoma (increased pressure in the eye)
• Have enlargement of the prostate gland

Before receiving TROPINE, inform your doctor if you:

• Have problems in mental and physical growth (ex. down's syndrome)
• Have an overactive thyroid gland
• Have diarrhea, heart burn or indigestion
• Have nerve damage
• Have ulcers or infections in the stomach or intestines
• Have hiatus hernia (protrusion of upper part of stomach into the chest)
• Have fever

Interactions

A. Drug-Drug interactions:

Before receiving TROPINE, inform your doctor if you are taking any of the
following medicines such as:

• Medicines used to manage abnormal heartbeat (ex. mexiletine, digoxin, disopyramide)
• Antihistamines (used to reduce allergic reactions) ex. diphenhydramine, chlorpheniramine
• Medicines used to manage depression such as tricyclic antidepressants (ex. amitriptyline, nortriptyline, doxepin)
• Anticholinesterase (used to reduce the activity of acetylcholine) ex. neostigmine or pyridostigmine)
• Medicines used to manage mental illness (ex. chlorpromazine, promethazine, haloperidol and droperidol)
• Amantadine (used to manage parkinsonism or viral infections)
• General anesthetics (used to induce loss of consciousness or sensation before surgery) ex. propofol
• Medicines used to manage nausea and vomiting (ex. domperidone)
• Ketoconazole (used to manage fungal infections)
• Medicines that dissolve slowly in your mouth (ex. sublingual tablets, chewable tablets or throat lozenges)

Overdosage:

TROPINE will be administered to you only by a doctor or a nurse in a hospital,
and so it is unlikely to receive an overdose. However, consult your doctor or
nurse if you experience any unpleasant symptoms such as dry mouth or burning
sensation in mouth, difficulty in swallowing, nausea, vomiting, skin rash, dry
or red skin, feeling sleepy, intolerance of light, high body temperature, high
blood pressure, irregular heart rate, breathing difficulties, restlessness,
hallucinations, severe confusion, excitement (delirium), or convulsions.

Synopsis

Drug	:	Atropine
Pharmacological Category	:	Muscarinic Receptor Antagonists
Therapeutic Indication	:	Restores heartbeat, reduces body secretions Manages Bradycardia, Stimulates muscle function Used in poisoning conditions
Dosage Forms	:	Eye Drops, Eye Ointment, Injection

More Information

Storage

• Keep TROPINE out of the sight and reach of children
• Store at room temperature

FAQs About TROPINE

Q: Can TROPINE be used for emergency conditions?

A: Yes. [GBNKEYWORD can be used during emergency conditions like cardiac arrest
to restore normal heartbeat. It can also use to manage poisoning caused due to
insecticides or mushrooms.

Q: What precautions do I need to follow while taking TROPINE?

A: Patients receiving TROPINE must inform their doctor about their pre-existing
disease conditions such as high blood pressure, coronary artery disease, angina,
chronic heart failure glaucoma, inflammation of the stomach and intestines or
blockade in the gut. Drink plenty of water or fluid after receiving TROPINE, as
it may lead to increased dryness of mouth. Avoid concomitant use of other heart
medicines with TROPINE without consulting your as it may increase the risk of
side effects.

Q: Can TROPINE be given via tracheal route?

A: Yes. TROPINE can be given into the trachea (via an endotracheal tube) if
necessary. It must be administrated only the doctor or nurse and cannot be
self-administered. Your doctor will decide the correct dose and suitable route
of administration for you depending upon the severity of your condition.

Q: Can TROPINE cause an increase in heart rate?

A: Yes. TROPINE is known to increase heart rate and is used to restore your
heart rate during emergency conditions like cardiac failure. TROPINE should be
used with caution in patients with high blood pressure, coronary artery disease,
and angina. Consult your doctor before receiving.

Q: Can TROPINE cause high blood pressure?

A: Yes. TROPINE restores normal heartbeat by increasing the blood pressure and
so, it must be used with caution among patients having heart diseases like high
blood pressure, chest pain or heart attack. Consult your doctor before
receiving.

Q: Can TROPINE be used on infants?

A: TROPINE is generally not recommended for use in very young children. Your
doctor might suggest a low dose depending upon the child’s age and body weight.
Therefore, consult your doctor for advice.

Q: Can TROPINE cause dry skin?

A: Yes. TROPINE can cause dry skin in some individuals. It is caused due to
decreased secretion of sweat (anhidrosis). Patients who received TROPINE are
advised to keep their skin hydrated always. Apply moisturizer generously to
affected dry areas of the skin. Drink plenty of water to keep yourself hydrated.
Consult your doctor for advice if you experience excessive skin dryness.

Q: Does TROPINE make your mouth dry?

A: Yes. TROPINE can cause dry mouth in some individuals. Drink plenty of water
and fruit juices. Consume soft foods with higher water and fiber content.
Artificial saliva can also be used in case of extreme dryness of mouth. Consult
your doctor if you experience dryness of mouth for prolonged period.

Useful Diagnostic Tests

• Healthy Midlife Checkup
• Full Body Checkup-Gold