Sviz LF 20/120mg Tablet 6'S

Introduction About SVIZ LF 20/120MG TABLET

SVIZ LF 20/120MG TABLET is a combination of Artemether and Lumefantrine which
belongs to the group of medicines called Antimalarials. It is used in infants,
children and adults for the management of acute uncomplicated malaria (mosquito
borne disease with symptoms of fever with chills, tiredness, nausea, vomiting,
stomach pain) caused by a parasite called plasmodium falciparum.

SVIZ LF 20/120MG TABLET should be used with caution in patients with severe
liver or kidney problems or if the patient feels worse or unwell to eat and
drink.

SVIZ LF 20/120MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the lungs, kidney or brain, heart condition
such as changes in the heart rhythm, slow heartbeat or severe heart disease and
low levels of electrolytes such as potassium or magnesium in the blood.

SVIZ LF 20/120MG TABLET is generally not recommended for use during the first
trimester of pregnancy and it should be used with caution during the second and
third trimester of pregnancy and breast-feeding women only if advised by the
doctor.

SVIZ LF 20/120MG TABLET should be used with caution in children and your child’s
doctor may adjust the dose depending upon child’s age and body weight.

The most common side effects of taking SVIZ LF 20/120MG TABLET are headache,
dizziness, vomiting, stomach pain, nausea, muscle pain and loss of appetite.
Consult your doctor if any of the side effects worsen.

Uses Of SVIZ LF 20/120MG TABLET

• Manage acute uncomplicated malarial infections (caused by plasmodium falciparum) in infants, children and adults

How SVIZ LF 20/120MG TABLET Works

SVIZ LF 20/120MG TABLET effectively manages malarial infections, whereartemether
effectively kills the malarial parasites by binding to haem (part of molecules
that contains iron which is toxic to malarial parasites) which is produced
during the breakdown of haemoglobin. Lumefantrine works by binding to hemin
where it manages the formation of a toxic malarial pigment called hemozoin,
thereby it manages malarial infection. In addition to this artemether and
lumefantrine blocks nucleic acid and protein synthesis in parasite that damages
the parasitic cell membrane of plasmodium falciparum which leads to the death of
parasite. Thus, it helps in managing the malarial infection.

How to use SVIZ LF 20/120MG TABLET

Take SVIZ LF 20/120MG TABLET exactly as advised by your doctor.

For Tablet, Capsule: Swallow SVIZ LF 20/120MG TABLET with a glass of water.
This medicine should be taken with food or drinks rich in fat such as milk.
Crush the medicine into powder if your child is unable to swallow the whole
medicine.

For Dispersible Tablet: Disperse SVIZ LF 20/120MG TABLET in the specified
quantity of water as mentioned in the label. Consume the mixture immediately
after reconstitution.

Your doctor will decide the correct dose and duration for you depending upon
your age, body weight and severity of the disease condition.

Side Effects Of SVIZ LF 20/120MG TABLET

Common

• headache, dizziness
• nausea, vomiting
• stomach pain
• diarrhea
• muscle or joint pain
• difficulty to sleep
• loss of appetite
• cough
• fast heartbeat
• general weakness, tiredness
• involuntary muscle spasms
• abnormal walking (in children above 12 years)
• tingling sensation or numbness of hand and feet
• rashes or itching in the skin
• disturbance in heart rhythm (prolonged QTc interval)

Uncommon

• sleepiness
• decreased skin sensitivity
• inability to coordinate movements

Rare

• allergic reactions

Stop taking SVIZ LF 20/120MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• swelling of the face, lips, tongue or throat with difficulty in breathing and swallowing
• skin condition with large fluid filled blisters (bullous eru

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the forehead if required. Do not consume too much of
alcohol. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily, fried or
spicy foods. Do not lie down or sleep immediately after eating. Consult your
doctor if the symptom does not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals.
Keep a heat pad on your stomach. Do not self-manage on your own and consult your
doctor if the symptom does not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom does not improve.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular
minimal exercise and follow regular sleep schedule. Consult your doctor if the
symptom does not improve.

Warning & Precautions

!### Pregnancy

SVIZ LF 20/120MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and third
trimester of pregnancy only if considered clearly necessary. Consult your doctor
before taking SVIZ LF 20/120MG TABLET.

!### Breastfeeding

SVIZ LF 20/120MG TABLET should be taken with caution in breast feeding women
only if considered clearly necessary. Consult your doctor before taking SVIZ LF
20/120MG TABLET.

!### Driving and Using Machines

Do not drive or operate any machines if you experience dizziness, sleepiness or
weakness after taking SVIZ LF 20/120MG TABLET.

!### Kidney

SVIZ LF 20/120MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken with
caution in patients with severe kidney problems. Consult your doctor before
taking SVIZ LF 20/120MG TABLET.

!### Liver

SVIZ LF 20/120MG TABLET should be taken with caution in patients with severe
liver problems. Consult your doctor before taking SVIZ LF 20/120MG TABLET.

!### Allergy

Do not take SVIZ LF 20/120MG TABLET if you are allergic to Artemether,
Lumefantrine or any other ingredients of this medicine.

!### Lungs

SVIZ LF 20/120MG TABLET is not recommended for use in patients having malaria
with pulmonary edema or severe type of malarial infection affecting the lungs.
Consult your doctor before taking it.

!### Heart Disease

SVIZ LF 20/120MG TABLET is not recommended for use in patients with severe heart
disease or with heart diseases such as slow heartbeat, changes in the rhythm or
rate of the heartbeat or family history of death due to heart problems or born
with heart problems. SVIZ LF 20/120MG TABLET should be taken with caution in
patients with variations in ECG (prolongation of QTc interval). Consult doctor
before taking SVIZ LF 20/120MG TABLET.

Others

SVIZ LF 20/120MG TABLET is not recommended for use if you have:

• severe type of malarial infection that has affected the brain
• low levels of electrolytes such as potassium or magnesium in blood

Before taking SVIZ LF 20/120MG TABLET, inform your doctor if you:

• infected with both the plasmodium falciparum and plasmodium vivax parasites
• feeling worse or if you feel too unwell to eat and drink

Use in pediatrics

SVIZ LF 20/120MG TABLET should be given with caution in children as the dosages
of SVIZ LF 20/120MG TABLET vary in children according to their body weight. So,
consult a paediatrician before you give this medicine to your child.

Use in geriatrics

SVIZ LF 20/120MG TABLET can be used in elderly patients. However, consult your
doctor before taking this medicine.

Interactions

A. Drug – drug interactions:

Before taking SVIZ LF 20/120MG TABLET, inform your doctor if you are taking any
of the following medicines:

• medicines used to manage heart rhythm problems (Ex. Flecainide, metoprolol)
• medicines used to manage depression (Ex. imipramine, amitriptyline, clomipramine, St. John’s wort)
• medicine used to manage leprosy or tuberculosis (Ex. rifampicin)
• medicines used to manage bacterial infections (EX.  fluroquinolones such as ciprofloxacin, levofloxacin, macrolide antibiotics like azithromycin, erythromycin)
• medicines used to manage fungal infection (Ex. ketoconazole, fluconazole, itraconazole)
• medicines used to manage allergy (Ex. terfenadine, astemizole)
• medicine used to manage stomach disturbance (Ex. cisapride)
• medicines used to manage fits (Ex. carbamazepine, phenytoin)
• medicines used to manage malaria (Ex.  atovaquone/progu
• medicines used to manage HIV infection (Ex. indinavir, ritonavir)
• medicine used to manage pregnancy (Ex. Ethinyl estradiol)

B. Drug – Food interactions

Drink grapefruit juice with caution while taking SVIZ LF 20/120MG TABLET as it
may interact with this medicine.

Overdosage:

If you or anyone else accidentally take too much of SVIZ LF 20/120MG TABLET,
consult your doctor immediately or visit a nearby hospital.

Synopsis

Drug	:	Artemether, Lumefantrine
Pharmacological Category	:	Antimalarials
Therapeutic Indication	:	Manages acute uncomplicated malaria
Dosage Forms	:	Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry Syrup

More Information

• Keep SVIZ LF 20/120MG TABLET out of reach of children
• Store SVIZ LF 20/120MG TABLET at room temperature

FAQs About SVIZ LF 20/120MG TABLET

What is SVIZ LF 20/120MG TABLET used for?

SVIZ LF 20/120MG TABLET is used in infants, children and adults for the
management of acute uncomplicated malaria (mosquito born disease with symptoms
of fever with chills, tiredness, nausea, vomiting, stomach pain) caused by a
parasite called plasmodium falciparum.

Does SVIZ LF 20/120MG TABLET helps to manage malaria?

SVIZ LF 20/120MG TABLET is not used to manage malaria. It is only used to manage
malarial infection caused by a parasite called plasmodium falciparum. Consult
your doctor for advice before taking this medicine.

Is SVIZ LF 20/120MG TABLET safe to use in pregnant women?

SVIZ LF 20/120MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and third
trimester of pregnancy only if considered clearly necessary. Consult your doctor
before taking SVIZ LF 20/120MG TABLET.

Can SVIZ LF 20/120MG TABLET be used in patients with kidney problems?

SVIZ LF 20/120MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken with
caution in patients with severe kidney problems. Consult your doctor before
taking SVIZ LF 20/120MG TABLET.

Does SVIZ LF 20/120MG TABLET cause diarrhea?

Yes, SVIZ LF 20/120MG TABLET may cause diarrhea in some individuals. To manage
this effect, drink lot of fluids such as water or fruit juices to keep yourself
hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult
your doctor if the symptom does not improve.

Useful Diagnostic Tests

• Peripheral Smear for Malaria