Stiloz 100mg Tablet 15'S

Introduction About STILOZ 100MG TABLET

STILOZ 100MG TABLET contains Cilostazol which belongs to the group of medicines
called Phosphodiesterase type 3 inhibitors. It is used in the management of
intermittent claudication, which is defined as the cramp-like pain in the legs
while walking caused by insufficient blood supply in the legs. Symptoms include
pain, ache, discomfort or fatigue in muscles every time, when those muscles are
used (usually the calves, thighs, buttocks, hips or feet).

Along with this management your doctor might advise you to make lifestyle
modifications like increasing regular exercise and stop smoking. Prior to the
management, your doctor may want you to take ankle-brachial index test to
understand your existing condition.

STILOZ 100MG TABLET is not recommended for use in patients having severe heart
problems (such as heart failure, heart attack), uncontrolled blood pressure,
kidney or liver disease, active stomach ulcer and stroke.

Do not drink large amounts of grapefruit juice while taking STILOZ 100MG TABLET
as it may reduce the effect of this medicine. STILOZ 100MG TABLET is not
recommended for use among pregnant or breastfeeding women, therefore consult
your doctor before taking it. This medicine is not recommended for use in
children and adolescents.

The most common side effects of taking STILOZ 100MG TABLET are headache,
abnormal stools, diarrhea, abdominal discomfort, dizziness, nausea and loss of
appetite.  Consult your doctor if any of the side effects worsen over the time.

Uses Of STILOZ 100MG TABLET

• Manage intermittent claudication

How STILOZ 100MG TABLET Works

STILOZ 100MG TABLET acts by inhibiting the activity of certain enzymes
(phosphodiesterase) which helps in the increase in the level of cAMP (cellular
messengers to initiate certain actions) in platelets and blood vessels. The cAMP
helps in widening of some blood vessels and reducing the clotting activity of
platelets inside the blood vessels. Hence increasing the blood circulation to
the legs making it easier and less painful to walk.

How to use STILOZ 100MG TABLET

Take STILOZ 100MG TABLET as advised by your physician. Swallow STILOZ 100MG
TABLET with a glass of water. Do not crush or chew the medicine. Your doctor
will decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of STILOZ 100MG TABLET

Common

• headache, dizziness
• abnormal stools, diarrhea
• heart pounding
• runny nose
• abdominal pain, abdominal discomfort (indigestion), excessive burping
• nausea or vomiting, general weakness
• loss of appetite
• swelling of the ankles, feet or face
• skin allergy (rash or changes in appearance of the skin, itchy skin, patchy bleeding in the skin)

Uncommon

• shortness of breath, cough, chills
• unexpected bleeding, tendency to bleed (Ex. nose bleeding and blood in spit or urine)
• fainting, anxiety
• difficulty sleeping, unusual dreams
• allergic reaction, aches and pains
• stomachache (gastritis)

Rare

• problems with the kidneys

Stop taking STILOZ 100MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• easy bruising and bleeding, fever or sore throat
• a pain or uncomfortable feeling in the chest, often spreading to the arms or neck and sometimes to the shoulders and back which may be caused by too little blood and oxygen supplying to the heart
• heart attack, irregular heartbeat, increased heart rate
• heart problems causing shortness of breath or ankle swelling
• increased blood sugar levels
• bleeding of the stomach and eyes
• pneumonia
• kidney failure

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Avoid taking any medicine on your own for managing
diarrhea. Consult your doctor if the symptom does not improve.

!### Dizziness Or Drowsiness

Lie down until dizziness goes away and then move slowly and carefully. Take
sufficient rest and drink plenty of fluids. Rise slowly after sitting or lying
down. Be careful while going up and down stairs. Consult your doctor if the
symptom worsens.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

!### Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily, fried and
spicy foods. Do not perform any strenuous activities immediately after eating.
Consult your doctor if the symptom does not improve.

!### Stomach Pain

Try to rest and relax. Eat and drink slowly or try to eat smaller meals more
frequently. Keep a heat pad on your stomach. Consult your doctor if the symptom
does not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedSTILOZ 100MG TABLET is not recommended for use in pregnant women. Consult your
doctor before taking STILOZ 100MG TABLET.

!### Breastfeeding

ContraindicatedSTILOZ 100MG TABLET is not recommended for use in breastfeeding women. Consult
your doctor before taking STILOZ 100MG TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate heavy machines if you experience dizziness while taking
STILOZ 100MG TABLET.

!### Kidney

ContraindicatedSTILOZ 100MG TABLET is not recommended for use in patients with severe kidney
disease. Consult your doctor before taking STILOZ 100MG TABLET.

!### Liver

ContraindicatedSTILOZ 100MG TABLET is not recommended for use in patients with moderate or
severe liver disease. Consult your doctor before taking STILOZ 100MG TABLET.

!### Allergy

ContraindicatedDo not take STILOZ 100MG TABLET if you are allergic to Cilostazol or any other
ingredients of this medicine.

!### Heart Disease

Consult your doctorSTILOZ 100MG TABLET is not recommended for use in patients with heart failure,
had heart attack, persistent chest pain at rest, any heart surgery in the last 6
months, suffered from blackouts due to heart disease or any severe disturbances
of the heartbeat. It should be taken with caution in patients with severe heart
problem or any other problems with your heart beat and high blood pressure.
Consult your doctor before taking STILOZ 100MG TABLET.

Others

STILOZ 100MG TABLET is not recommended for use if you:

• have any condition which increases the risk of bleeding or bruising, such as active stomach ulcers, stroke in the past six months, eye problems with diabetes and uncontrolled blood pressure

Before taking STILOZ 100MG TABLET, inform your doctor if you:

• need to have surgery (including teeth removal)

Use in pediatrics:

STILOZ 100MG TABLET is not recommended for use in children and adolescents.
Consult your child’s doctor for advice.

Use in geriatrics:

STILOZ 100MG TABLET should be taken with caution in elderly patients. Consult
your doctor before taking STILOZ 100MG TABLET.

Interactions

A. Drug-Drug interactions:

Before taking STILOZ 100MG TABLET, inform your doctor if you are taking any of
the following medicines:

• acetylsalicylic acid (aspirin) (used to manage painful inflammatory condition of muscle or joints)
• anticoagulant medicines (Ex. heparin, warfarin, clopidogrel, dabigatran, rivaroxaban, apixaban) (used to manage or manage blood clots)
• certain antibiotics Ex. erythromycin, clarithromycin or rifampicin (used to manage bacterial infections)
• ketoconazole (used to manage fungal infections)
• omeprazole (used to manage acidity in the stomach)
• diltiazem (used to manage high blood pressure or chest pain)
• cisapride (used to manage stomach disorders)
• medicines used to manage high cholesterol in the blood (Ex. lovastatin, simvastatin)
• halofantrine (used to manage malaria)
• protease inhibitors such as atazanavir, darunavir (used to manage HIV infection)
• pimozide (used to manage mental illnesses)
• ergot derivatives Ex. ergotamine, dihydroergotamine (used to manage or manage migraine headaches)
• st. john’s wort (herbal remedy), carbamazepine or phenytoin (used to manage convulsions)
• diuretics Ex. hydrochlorothiazide, furosemide (used to manage fluid retention)
• calcium channel blockers such as verapamil, amlodipine, angiotensin-converting-enzyme inhibitors such as captopril, lisinopril, angiotensin II receptor blockers such as valsartan, candesartan and beta blockers such as labetalol, carvedilol (used to manage high blood pressure)

B. Drug-Food interactions:

Do not drink large amounts of grapefruit juice while taking STILOZ 100MG TABLET
as it may reduce the effect of this medicine and do not take together with meals
as it may affects its absor

Overdosage:

If you or anyone else accidentally take too much of STILOZ 100MG TABLET, consult
your doctor immediately or visit the nearby hospital. Overdosage symptoms of
STILOZ 100MG TABLET includes severe headache, diarrhea, increase in heart rate
and irregularities of the heartbeat.

Synopsis

Drug	:	Cilostazol
Pharmacological Category	:	Platelet aggregation inhibitors
Therapeutic Indication	:	Intermittent claudication
Dosage Forms	:	Tablet

More Information

• Keep STILOZ 100MG TABLET out of reach of children
• Store STILOZ 100MG TABLET at room temperature

FAQs About STILOZ 100MG TABLET

Q: How does STILOZ 100MG TABLET work?

A: STILOZ 100MG TABLET acts by inhibiting the activity of certain enzymes
(phosphodiesterase) which helps in the increase in the level of cAMP (cellular
messengers to initiate certain actions) in platelets and blood vessels. The cAMP
helps in widening of some blood vessels and reducing the clotting activity of
platelets inside the blood vessels. Hence increasing the blood circulation to
the legs making it easier and less painful to walk.

Q: What is STILOZ 100MG TABLET used for?

A: STILOZ 100MG TABLET is used in the management of intermittent claudication,
which is defined as the cramp-like pain in the legs while walking caused by
insufficient blood supply in the legs. Symptoms include pain, ache, discomfort
or fatigue in muscles every time, when those muscles are used (usually the
calves, thighs, buttocks, hips or feet).

Q: Can I stop taking STILOZ 100MG TABLET on my own?

A: If you stop taking STILOZ 100MG TABLET the pain in your legs may come back or
get worse. Therefore, you should only stop taking it if you notice side effects
requiring urgent medical attentionor if your doctor tells you to.

Q: What to do If I forget to take a dose of STILOZ 100MG TABLET?

A: You should take STILOZ 100MG TABLET immediately when you remember. If it is
time for the next dose skip the missed dose and follow the regular dose
schedule. Do not double the dose to match up the missed dose.

Q: CanSTILOZ 100MG TABLET be used in pregnant or breast-feeding women?

A: STILOZ 100MG TABLET is not recommended for use in pregnant and breast-feeding
women. Consult your doctor before taking this medicine if you are pregnant,
planning to become pregnant or breast-feeding your child.

Useful Diagnostic Tests

• Ankle-brachial index test