Serran D Tablet 10'S

Introduction About SERRAN D TABLET

SERRAN D TABLET is a combination of Diclofenac and Serratiope
belongs to a group of medicines called Nonsteroidal anti-inflammatory drugs and
Proteolytic enzymes.  SERRAN D TABLET is used in the management of pain and
inflammatory conditions in adult patients. SERRAN D TABLET is not recommended
for use in patients allergic to diclofenac, aspirin, ibuprofen, other NSAIDs,
and/or serratiope
patients with active gastric or intestinal ulcer/bleeding/perforation,
active/previous history of recurrent pe
arterial disease (blood circulation disorder), severe liver/kidney impairment,
and/or heart diseases (such as congestive heart failure, severe heart failure,
ischemic heart disease). SERRAN D TABLET is also not indicated for use to manage
pain in patients who had undergone coronary artery bypass graft (CABG) surgery.

Before taking SERRAN D TABLET inform your doctor if you had previously suffered
from gastrointestinal ulceration, and/or have ulcerative colitis (inflammation
of colon), mixed connective tissue disorders (such as systemic lupus
erythematosus), diabetes, high blood pressure, lung problems (such as bronchial
asthma, chronic obstructive pulmonary diseases), kidney problems (such as mild
to moderate renal impairment), and/or liver problems (such as mild to moderate
liver impairment).

SERRAN D TABLET is generally not recommended for use during third trimester of
pregnancy which is also not recommended for use in women planning for pregnancy.
SERRAN D TABLET should be used with caution during first and second trimester of
pregnancy only if it is clearly necessary. SERRAN D TABLET is also not
recommended for use in breastfeeding women since it may pass through breastmilk.
Consult your doctor before taking the medicine.

SERRAN D TABLET is not recommended for use in children and adolescents (aged
below 18 years) at higher doses which should be used with caution in children
and adolescents (aged above 14 years) at lower doses after consulting the
doctor. SERRAN D TABLET should also be used with caution in elderly patients
(aged above 65 years) after consulting the doctor. The most common side effects
of taking SERRAN D TABLET are headache, dizziness, abdominal pain, indigestion,
nausea, vomiting, and/or diarrhea.  Consult your doctor if any of these symptoms
worsen.

Uses Of SERRAN D TABLET

• Used to manage pain and inflammatory conditions

How SERRAN D TABLET Works

SERRAN D TABLET provides relief from pain and inflammation in affected
individuals where diclofenac works by inhibiting the release of certain chemical
messengers (responsible for pain and inflammation) in the brain and
serratiope
proteins at the site of inflammation thus providing relief from inflammation and
pain in affected individuals.

How to use SERRAN D TABLET

Take SERRAN D TABLET as advised by your physician. Your doctor will decide the
correct dose, duration and frequency for you depending on your age, body weight
and disease condition.

Side Effects Of SERRAN D TABLET

Common

• Headache
• Dizziness
• Nausea
• Vomiting
• Diarrhea
• Indigestion
• abdominal pain
• flatulence
• anorexia (eating disorder)
• loss of appetite
• rash
• red itchy welts

Uncommon

• racing heartbeat
• chest pain

Rare

• Signs of hypersensitivity and anaphylactic reactions (life threatening allergic reactions) such as low blood pressure, red itchy welts, flushed/pale skin, shortness of breath, and/or wheezing
• Excess sleepiness, tiredness
• Asthma, difficulty in breathing
• Stomach inflammation, gastrointestinal bleeding, dark stools, bloody diarrhea, stomach ulcer with/without bleeding/perforation
• Inflammation of liver, jaundice, liver disorders
• Bullous eru
• Swelling in arms and legs

Stop taking SERRAN D TABLET and contact your doctor immediately if you
experience any of the following side effects:

• Skin rash, mucosal lesions, hypersensitivity reaction (associated with signs such as red itchy welts, skin rash, shortness of breath, wheezing, and/or fever)
• Stomach pain, indigestion, heartburn, wind, nausea, vomiting
• Signs of bleeding in the stomach/intestine such as abdominal cramps, black/tarry stool, bright red blood in vomit, and/or dizziness/faintness
• Signs of allergic reactions such as skin rash, itching, bruising, painful red areas, peeling/blistering
• Wheezing/shortness of breath
• Swollen face, lips, hands or fingers
• Signs of jaundice such as yellowing of your skin or the whites of your eyes
• Persistent sore throat/high temperature
• Change in quantity of urine and its appearance
• Mild cramping and tenderness of abdomen followed by rectal bleeding/bloody diarrhea usually within 24 hours of the onset of abdominal pain
• Signs of Stevens-Johnson syndrome (serious skin disorder) such as blistering of the skin, mouth, eyes and genitals
• Chest pain due to Kounis syndrome (serious allergic reaction)

How To Manage Side Effects

!### Diarrhea

If SERRAN D TABLET causes diarrhea, then drink plenty of water and stay
hydrated. Try to avoid taking any medicine on your own to manage diarrhea.
Consult your doctor and inform them if the symptom gets worse.

!### Dizziness Or Drowsiness

If SERRAN D TABLET causes dizziness, then try to take rest and get enough sleep.
Try to avoid driving or operating any tools or machines while you feel dizzy.
Limit consum
your doctor if the symptom worsens.

Headache

If SERRAN D TABLET causes headache, then take rest and drink plenty of fluids.
Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller.
Headaches should usually go away after the first week of taking SERRAN D TABLET.
If it lasts more than a week or severe, inform your doctor.

!### Indigestion

If SERRAN D TABLET causes indigestion, then try to have smaller and more
frequent meals and drink slowly. Reduce consum
alcohol and lose weight if you are obese.  Try to avoid smoking and don’t have
rich, fatty or spicy foods. Consult your doctor and inform if the symptom does
not improve.

!### Nausea And Vomiting

If SERRAN D TABLET causes nausea and vomiting, then try to take SERRAN D TABLET
with or just after a meal or a snack. Stick to simple meals. Avoid eating rich
or spicy food. Consult your doctor if symptom gets worse.

Warning & Precautions

!### Pregnancy

Consult your doctorSERRAN D TABLET is generally not recommended for use during third trimester of
pregnancy. It is also not recommended for use in women planning for pregnancy.
SERRAN D TABLET should be used with caution during first and second trimester of
pregnancy only if it is clearly necessary. Consult your doctor before taking
SERRAN D TABLET.

!### Breastfeeding

ContraindicatedSERRAN D TABLET is not recommended for use in breastfeeding women since it may
pass through breastmilk. Consult your doctor before taking SERRAN D TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel/experience visual disturbances,
dizziness, spinning sensation, excess sleepiness, drowsiness, and/or tiredness
after taking SERRAN D TABLET.

!### Alcohol

Consult your doctorAvoid consum
risk of gastrointestinal bleeding.

!### Kidney

Consult your doctorSERRAN D TABLET is not recommended for use in patients with severe renal
impairment. It should be used with caution in patients with mild to moderate
renal impairment. Consult your doctor before taking SERRAN D TABLET.

!### Liver

Consult your doctorSERRAN D TABLET is not recommended for use in patients with severe hepatic
impairment and liver failure. It should be used with caution in patients with
mild to moderate hepatic impairment and hepatic porphyria. Consult your doctor
before taking SERRAN D TABLET.

!### Allergy

ContraindicatedDo not take SERRAN D TABLET if you are allergic to diclofenac, aspirin,
ibuprofen, other NSAIDs, serratiope
medicine.

!### Lungs

Use with CautionSERRAN D TABLET should be used with caution in patients with lung problems such
as bronchial asthma, chronic obstructive pulmonary diseases, and/or chronic
infections of the respiratory tract. Consult your doctor before taking SERRAN D
TABLET.

!### Heart Disease

ContraindicatedSERRAN D TABLET is not recommended for use in patients with established
congestive heart failure, severe heart failure, and/or ischemic heart disease,
It is also not recommended for use in patients who had undergone coronary artery
bypass graft (CABG) surgery. Consult your doctor before taking SERRAN D TABLET.

!### Use In Pediatrics

Consult your doctorSERRAN D TABLET is not recommended for use in children and adolescents (below 18
years) at higher doses. It should be used with caution in children and
adolescents (aged above 14 years) at lower doses.  Consult your doctor before
taking the medicine who shall decide the correct dose, duration and frequency
depending on the child’s age, body weight and disease condition.

!### Use In Geriatrics

Use with CautionSERRAN D TABLET should be used with caution in elderly patients (aged above 65
years). Consult your doctor before taking the medicine.

Others

SERRAN D TABLET is not recommended for use if you:

• Have active gastric or intestinal ulcer/bleeding/perforation
• Previously suffered from gastrointestinal bleeding/perforation (due to NSADIS therapy)
• Have active/previous history of recurrent pe
• Previously suffered from angio-oedema, red itchy welts, acute rhinitis gastrointestinal (due to NSAIDS therapy)
• Previously had stomach/bowel problems (after taking other NSAIDs)
• Have/had peripheral arterial disease (blood circulation disorder).
• Other cerebrovascular diseases (such as stroke, ministroke).
• Have rare hereditary problems of galactose intolerance, severe lactase deficiency/glucose-galactose malabsor

Before taking SERRAN D TABLET, inform your doctor if you:

• Have previously suffered from gastrointestinal ulceration
• Have ulcerative colitis (inflammation of colon) or crohn’s disease (inflammatory bowel disease)
• Suffer from mixed connective tissue disorders such as systemic lupus erythematosus (type of autoimmune disease)
• Have diabetes, high blood pressure, hyperlipidemia (high cholesterol level in blood)
• Are a smoker
• Suffer from defective hemostasis (process to prevent/stop bleeding), bleeding diathesis/ hematological abnormalities (increased susce

Interactions

A. Drug-Drug interactions:

Before taking SERRAN D TABLET, inform your doctor, if you are taking any of the
following medicine:

• Lithium (used for depression)
• Digoxin, quinidine (medicines used to manage heart disease)
• Medicines used for hypertension such as diuretics (Ex. chlorothiazide, chlorthalidone), beta blockers (Ex. acebutolol, atenolol), angiotensin-converting enzyme inhibitors (Ex. benazepril, captopril)
• Potassium-sparing diuretic (used to manage hypertension, cirrhosis, congestive heart failure) Ex. amiloride, eplerenone
• Ciclosporin (used to manage transplant organ rejection)
• Tacrolimus (used to manage moderate to severe atopic dermatitis)
• Trimethoprim (used to manage urinary tract infections)
• Anticoagulants (medicines used to manage blood clot) Ex. aspirin, warfarin
• Other NSAIDS (medicines used to reduce pain and inflammation) such as cox 2 selective inhibitors (Ex. celecoxib, valdecoxib), corticosteroids (Ex. cortisone, hydrocortisone)
• Selective serotonin reuptake inhibitors (medicines used to manage depression) Ex. citalopram, dapoxetine
• Antidiabetics (medicines used to manage diabetes) Ex. metformin, glipizide, glyburide
• Methotrexate (used to manage inflammatory conditions)
• Quinolone (used to manage bacterial infections)
• Phenytoin (used to manage seizures)
• Colestipol, Cholestyramine (medicines used to lower high cholesterol in blood)
• Cardiac glycosides (medicines used to manage heart failure and certain irregular heartbeats) Ex. acetyldigitoxin, deslanoside
• Mifepristone (used to end early pregnancy)

Overdosage:

If you or anyone else accidentally take too much of SERRAN D TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
headache, nausea, vomiting, epigastric pain, GI hemorrhage, diarrhea, dizziness,
disorientation, excitation, coma, drowsiness, tinnitus, fainting, and/or
convulsions.

Synopsis

Drug	:	Diclofenac, Serratiope
Pharmacological Category	:	Non-steroidal anti-inflammatory drug, Proteolytic Enzyme
Therapeutic Indication	:	Pain and inflammatory conditions
Dosage Forms	:	Capsule, Tablet, Orally Disintegrating Tablet

More Information

Storage

• Keep out of reach from children
• Store below 25°C

FAQs About SERRAN D TABLET

Q: What is SERRAN D TABLET and why it is used?

A: SERRAN D TABLET is a combination of Diclofenac and Serratiope
belongs to a group of medicines called Nonsteroidal anti-inflammatory drugs and
Proteolytic enzymes, which is generally indicated in adult patients to manage
pain and inflammatory conditions.

Q: How SERRAN D TABLET works?

A: SERRAN D TABLET provides relief from pain and inflammation in affected
individuals where diclofenac works by inhibiting the release of certain chemical
messengers (responsible for pain and inflammation) in the brain and
serratiope
proteins at the site of inflammation thus providing relief from inflammation and
pain in affected individuals.

Q: What are the most common side effects of taking SERRAN D TABLET?

A: The most common side effects of taking SERRAN D TABLET are headache,
dizziness, abdominal pain, indigestion, nausea, vomiting, and/or
diarrhea. Consult your doctor if any of these symptoms worsen.

Q: What happens if more dose of SERRAN D TABLET is taken than the required dose?

A: If you or anyone else accidentally take too much of SERRAN D TABLET, consult
your doctor immediately or visit the nearby hospital. Symptoms of overdose are
headache, nausea, vomiting, epigastric pain, GI hemorrhage, diarrhea, dizziness,
disorientation, excitation, coma, drowsiness, tinnitus, fainting, and/or
convulsions.

Q: Can SERRAN D TABLET be used during pregnancy?

A: No, SERRAN D TABLET is not recommended for use in pregnant women especially
during third trimester stage. It is also not recommended for use in women
planning for pregnancy. However, it can be used with caution during first and
second trimester of pregnancy provided if it is clearly necessary. Consult your
doctor before taking the medicine.

Useful Diagnostic Tests

• Blood tests, CRP tests
• Kidney function test
• Liver function test