SERENACE 0.25 Tablet 20's

Introduction About SERENACE 0.25 TABLET

SERENACE 0.25 TABLET contains Haloperidol which belongs to the group of
medicines called Antipsychotics. It is used to manage mental health problems
like schizophrenia, bipolar disorder and behavioural problems which affects the
person’s ability to think, feel and behave normally.

SERENACE 0.25 TABLET is also used to manage Huntington’s disease (degeneration
of nerve cells in the brain) and Tourette’s syndrome (disease involving unwanted
sounds or repetitive movements).

Your doctor might want you to take several diagnostic tests before or during
your management with SERENACE 0.25 TABLET such as ECG (electrocardiogram) or
checking the levels of electrolytes such as magnesium or potassium in your
blood.

SERENACE 0.25 TABLET is not recommended in patients having heart disease,
Parkinson’s disease, Lewy body dementia, progressive supranuclear palsy, or low
potassium levels. Before taking SERENACE 0.25 TABLET, inform your doctor if you
have kidney problems, liver problems, thyroid problems, blood disorders,
depression, bleeding in the brain, prolactin-dependent tumors, or epilepsy.

SERENACE 0.25 TABLET should be used with caution in pregnant women only if the
potential benefit justifies the potential risk to the baby and is not
recommended for use in breastfeeding women. Avoid consum
management with SERENACE 0.25 TABLET, as it may have additive side effects and
lower the blood pressure.

SERENACE 0.25 TABLET is not recommended for use in children under 3 years of age
and should be used with caution in elderly patients. The most common side
effects of taking SERENACE 0.25 TABLET are feeling agitated, difficulty
sleeping, headache, dizziness, sleepiness, nausea, vomiting or constipation.
Contact your doctor if any of the above symptoms worsen or doesn’t improve.

Uses Of SERENACE 0.25 TABLET

Manages mental health problems such as:

• schizophrenia
• bipolar disorder
• behavioural problems
• Huntington’s disease
• Tourette’s syndrome

How SERENACE 0.25 TABLET Works

SERENACE 0.25 TABLET contains Haloperidol which is an antipsychotic that works
by blocking certain receptors in the brain called dopamine (D2) receptors. This
decreases the levels of dopamine, a nerve chemical. Thus, rebalancing dopamine
to improve thinking, mood, and behaviour.

How to use SERENACE 0.25 TABLET

Take SERENACE 0.25 TABLET as advised by your doctor. Swallow the medicine with
enough water. Do not crush or chew the medicine. Try to take SERENACE 0.25
TABLET daily at the same time in the evening.  Your doctor will decide the
correct dose and duration of SERENACE 0.25 TABLET for you depending on your age,
body weight, and disease condition.

Side Effects Of SERENACE 0.25 TABLET

Common

• agitation
• difficulty sleeping or sleepiness
• headache
• delusions (a false belief about the things which are not there)
• hallucinations (perce
• depression
• abnormal muscle tension
• dizziness, including sitting or standing up
• fast or upward eye movements, uncontrollable eye movements
• blurred vision
• low blood pressure
• nausea
• vomiting
• constipation
• dry mouth or increased saliva
• skin rash
• unable to pass urine or completely empty the bladder
• impotence (difficulty in getting and keeping an erection)
• weight gain or loss
• changes in liver function (abdominal pain, nausea, vomiting, dark urine, pale stool, jaundice)

Uncommon

• decreased white blood cells and platelets (fever, bleeding easily)
• confusion
• decreased or loss of libido
• fits (seizures)
• stiff muscles and joints
• muscle spasms, twitching, or contractions
• neck spasm causing the neck to twist on one side
• problems in walking
• shortness of breath
• increased skin sensitivity to sunlight
• itching
• excessive sweating
• changes in the menstrual cycle (periods) (like no periods, or long, heavy, painful periods)
• production of breast milk suddenly, breast pain or discomfort
• high body temperature
• swelling caused by fluid that is build-up in the body

Rare

• difficulty breathing due to narrowed airways
• unable to or difficulty in opening mouth
• high levels of prolactin in the blood (changes in menstrual cycle, infertility, menopausal symptoms)

Stop taking SERENACE 0.25 TABLET and contact your physician immediately if you
experience any of the following side effects:

• neurole
• heart problems such as irregular heartbeat, abnormally fast heartbeat, extra heartbeats
• extrapyramidal disorder (problems controlling movements of the body or limbs) (signs include movements of the mouth, tongue, jaw, and sometimes limbs, feeling restless or difficulty sitting, increased body movements, slow or reduced body movements, jerking or twisting movements, muscle tremors or stiffness, a shuffling walk, being unable to move, and lack of normal facial expression)
• severe allergic reaction (signs include a swollen face, lips, mouth, tongue, or throat, difficulty swallowing or breathing, and itchy rash (hives))
• blood clots in the veins, especially in the legs that can move to lungs

How To Manage Side Effects

Nausea:

Take SERENACE 0.25 TABLET with or after meals. Stick to simple meals while
taking SERENACE 0.25 TABLET. Avoid eating rich or spicy food. Do not take any
medication on your own. Ask for your doctor’s advice if the nausea doesn’t
improve.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Rest in a
quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your
doctor’s advice if the headache doesn’t improve

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily, or
sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting
doesn’t improve.

Dizziness:

Lie, or sit down immediately when you feel dizzy. If you're feeling severe
episodes of spinning(vertigo), lie in a dark and quiet place with your eyes
closed. Try to avoid vehicle driving. Discuss with your doctor if the symptom
worsens.

Constipation:

Eat plenty of fibre-rich foods such as vegetables, fresh fruits, and cereals and
drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if
constipation doesn’t improve.

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard
candies to stimulate the flow of saliva. Sip water at regular intervals of time.
Do not use mouthwashes that contain alcohol because they can be drying. Consult
your physician for advice.

Warning & Precautions

!### Pregnancy

SERENACE 0.25 TABLET should be used with caution in pregnant women only if the
potential benefit outweighs the potential risk to the unborn baby. If SERENACE
0.25 TABLET is taken during third trimester it may cause muscle tremors, stiff
or weak muscles, being sleepy or agitated, or problems in breathing or feeding
in newborn babies. Consult your doctor before taking SERENACE 0.25 TABLET.

!### Breastfeeding

SERENACE 0.25 TABLET is not recommended for use in breastfeeding women. Consult
your doctor before taking it.

!### Driving and Using Machines

Do not drive or use machinery if you feel sleepy or have reduced alertness after
taking SERENACE 0.25 TABLET.

!### Alcohol

Avoid consum
you sleepy, less alert and lower down the blood pressure.

!### Kidney

SERENACE 0.25 TABLET should be used with caution in patients with kidney
diseases. Consult your doctor before taking it.

!### Liver

SERENACE 0.25 TABLET should be taken with caution in patients with liver
diseases. Consult your doctor before taking it.

!### Allergy

Do not take SERENACE 0.25 TABLET if you are allergic to Haloperidol or any of
the other ingredients of this medicine.

!### Heart Disease

SERENACE 0.25 TABLET is not recommended in patients having heart conditions like
prolonged QT interval or any other problem with the heart rhythm, heart failure,
or recently had a heart attack. SERENACE 0.25 TABLET should be used with caution
in patients having other heart diseases such as slow heartbeat. Consult your
doctor before taking SERENACE 0.25 TABLET.

Others

SERENACE 0.25 TABLET is not recommended for use if you have:

• lack of awareness of things around you or unusually slow reactions
• Parkinson’s disease
• Lewy body dementia
• progressive supranuclear palsy (PSP)
• low levels of potassium in the blood which is not being manageed

Before taking SERENACE 0.25 TABLET, inform your doctor if you have:

• thyroid problems
• low blood pressure or dizziness while standing up or sitting
• low levels of magnesium or other electrolytes
• bleeding in the brain or a tendency to have a stroke
• history of blood clots or any of your family member has it
• depression or bipolar disorder
• high levels of prolactin or tumor such as breast cancer
• epilepsy or ever had fits
• lactose intolerance

Use in pediatrics:

SERENACE 0.25 TABLET is not recommended to use in children below 3 years of age.
Consult your child’s doctor before giving SERENACE 0.25 TABLET to your child.

Use in geriatrics:

SERENACE 0.25 TABLET should be used with caution in elderly patients. Your
doctor may adjust your dose depending on your present condition, age and body
weight. Consult your doctor before taking SERENACE 0.25 TABLET.

Interactions

A. Drug-Drug interactions:

Before taking SERENACE 0.25 TABLET, inform your doctor if you are taking any of
the following medicine:

• medicines used to manage heart problems (Ex. amiodarone, dofetilide, disopyramide, dronedarone, ibutilide, quinidine, verapamil, guanethidine, methyldopa, bepridil and sotalol)
• medicine used to manage depression (Ex. citalopram and escitalopram), anxiety or induce sleep (Ex. alprazolam or buspirone)
• medicines used to manage psychoses (Ex. levomepromazine, fluphenazine, perphenazine, pimozide, sertindole, prochlorperazine, promazine, thioridazine, trifluoperazine, triflupromazine, fluvoxamine, duloxetine, fluoxetine, paroxetine, nefazodone, sertraline, St John’s Wort (herbal), or venlafaxine and ziprasidone)
• medicine used to manage bacterial infections (Ex. azithromycin, rifampicin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, and telithromycin)
• medicine used to manage fungal infections (Ex. pentamidine, itraconazole, posaconazole or voriconazole)
• halofantrine (used to manage malaria)
• medicine used to manage nausea and vomiting (Ex. dolasetron, chlorpromazine, promethazine)
• medicine used to manage cancer (Ex. toremifene and vandet
• medicine used to manage pain or drug addiction (Ex. methadone)
• medicine used to manage epilepsy (Ex. carbamazepine, phenobarbital, or phenytoin)
• medicine used to help you leave smoking (Ex. bupropion)
• medicine used to manage Cushing’s syndrome (Ex. ketoconazole)
• medicine used to manage human immunodeficiency virus or HIV (Ex. indinavir, ritonavir, or saquinavir)
• medicines used to manage severe allergic reactions (Ex. adrenaline)
• medicines used to manage attention deficit hyperactivity disorder (ADHD) (Ex. methylphenidate), Parkinson’s diseases (Ex. levodopa)
• medicines used as blood thinners (Ex. phenindione)

Overdosage:

If you or anyone else accidentally took more of SERENACE 0.25 TABLET, consult
your doctor immediately or visit the nearby hospital. The symptoms of overdosage
are extrapyramidal reactions (problems controlling movements of the body), low
blood pressure, and sedation.

Synopsis

Drug	:	Haloperidol
Pharmacological Category	:	Antipsychotic
Therapeutic Indication	:	Management of mental health problems
Dosage Forms	:	Tablet, Injection, Syrup, Liquid

More Information

• Keep SERENACE 0.25 TABLET out of reach of children
• Store SERENACE 0.25 TABLET at a temperature, not more than 25°C

FAQs About SERENACE 0.25 TABLET

What if I forget to take a dose of SERENACE 0.25 TABLET?

If you forget a dose of SERENACE 0.25 TABLET, take it as soon as you remember.
However, if it is almost time for the next dose, skip the missed dose and take
the next scheduled dose at the prescribed time. Do not double the dose to make
up for the missed dose as this may increase the chances of developing side
effects.

Can SERENACE 0.25 TABLET cause headaches?

Yes. Headache is one of the most common side effects of taking SERENACE 0.25
TABLET. Keep yourself hydrated by drinking more fluids such as water or
electrolytes. If needed apply a pain-relieving balm on the forehead. Avoid
consum
consult your doctor for advice.

Is driving a car safe after taking SERENACE 0.25 TABLET?

SERENACE 0.25 TABLET may impair mental and/or physical abilities. Do not drive
or operate any machines if you feel sleepy or have reduced alertness taking
SERENACE 0.25 TABLET. You can resume doing your activities as soon as you feel
normal again.

Is SERENACE 0.25 TABLET safe for use in elderly patients?

SERENACE 0.25 TABLET should be used with caution in elderly patients. Your
doctor may adjust your dose depending on your present condition, age and body
weight. Some serious side effects have been reported in elderly patients having
dementia. Consult your doctor before taking SERENACE 0.25 TABLET.

Can I stop taking SERENACE 0.25 TABLET on my own?

Do not stop taking SERENACE 0.25 TABLET until and unless you are told by your
doctor to do so. Stopping management suddenly may cause side effects such as
nausea, vomiting, or difficulty in sleep. Ask for your doctor’s advice if you
wish to discontinue your management with GBNKEYWORD].

Do I need to undergo any diagnostic tests before or while being managed with
SERENACE 0.25 TABLET?

Your doctor might want you to take several diagnostic tests before or during
your management with SERENACE 0.25 TABLET such as ECG (electrocardiogram) or
checking the levels of electrolytes such as magnesium or potassium in your
blood.

Useful Diagnostic Tests

• Electrocardiogram (ECG)
• Serum electrolytes
• EEG (Electroencephalogram)