RCIN 300MG CAPSULE 10'S(N) (N)

Introduction About RCIN

RCIN contains Rifampicin which belongs to the group of medicines called
Antibacterial. It is used to manage bacterial infections such as tuberculosis
(affects the lungs), legionnaires disease (lung inflammation), brucellosis
(infection spreading from
nerve damage) and serious staphylococcal infections.

It also manages the infections caused by Haemophilus influenzae and Neisseria
meningitides (who are the carriers but do not show the symptoms), thereby
managing and managing the onset of flu and meningitis. The doctor may ask you to
take blood tests and liver function tests before starting management with RCIN.
RCIN is not recommended for use if you have yellowing of the skin and eyes
(jaundice).

Before taking RCIN, it is recommended to inform your doctor if you have liver,
kidney problems, diabetes, are underweight or malnourished, have a rare blood
problem (porphyria), bleeding or a tendency to bruise easily. Also, inform your
doctor if symptoms of tuberculosis return or get worse, are wearing contact
lenses, are vitamin K deficient or have hypoprothrombinemia (deficient clotting
factor).

RCIN is not recommended for use in pregnant and breastfeeding women. RCIN should
be used with caution in children under 2 years of age and in elderly patients
above 65 years of age. The most common side effects seen are nausea, vomiting,
chills, fever. Consult your doctor if symptoms do not improve.

Uses Of RCIN

RCIN is used to manage:

• tuberculosis
• leprosy
• brucellosis
• legionnaires
• serious staphylococcal infections
• infections caused by Haemophilus influenzae (causes flu) and Neisseria meningitides (causes meningitis)

How RCIN Works

RCIN works by managing protein synthesis and interferes with the enzymes present
in the bacteria causing its death. This results in a reduction in the count of
infection-causing bacteria, thereby managing bacterial infections.

How to use RCIN

Take RCIN as advised by your physician. Swallow the medicine with a glass of
water. Do not crush or chew the medicine. It is recommended to take RCIN on an
empty stomach. Your doctor will decide the correct dose and duration for you
depending on your age, body weight and disease condition.

Side Effects Of RCIN

Common

• headache, dizziness
• nausea and vomiting
• pyrexia (fever)
• chills
• thrombocytopenia with or without purpura (low platelet level)

Rare

Stop taking RCIN and consult your doctor immediately if you experience any of
the following:

• allergic reactions such as swollen face, lips, tongue, throat causing difficulty in breathing and/or swallowing
• skin reactions characterized by fever, red colored circular patches on skin with central blisters along with skin peeling and ulcers on mouth, nose, throat and/or genitals, which may indicate Steven Johnson Syndrome and/or Toxic Epidermal Necrolysis
• severe watery, frequent loose stools and/or with presence of blood in it, along with weakness and/or fever
• flu- like symptoms along with the appearance of a rash which are widespread in nature, increased temperature and enlarged lymph nodes which are characteristic of DRESS (Drug Reaction with Eosinophilia and Systemic symptoms)
• development of purple spots and/or bruises on skin
• severe headache
• bleeding from various parts such as nose, ears, gums, throat
• tender and/or swollen stomach
• black tar-like stools
• loss of weight, decreased blood sugar levels (hypoglycemia), dehydration, disorientation (adrenal insufficiency)
• pain in abdomen along with increased blood pressure and rapid abnormal heartbeat, which may indicate Porphyria
• red and scaly rash which is widely spread on body with bumps under the skin along with fever (acute generalized exanthematous pustulosis (AGEP))
• altered amount of urine along with the presence of blood in it, feeling weak and drowsy (kidney problem)
• dark urine along pale stools and yellowing of skin and eyes (liver problem)
• return of the original symptoms and/or increase in the severity of pre-existing symptoms (Paradoxical Drug Reaction). ( associated with fever, swollen lymph nodes (lymphadenitis), breathlessness, cough, headaches, loss of appetite and weight loss)
• swollen blood vessels in the skin
• fever, chills, headache, dizziness and bone pain
• mental problems causing a change in personality, hallucinations and odd behavior (psychotic disorder)

How To Manage Side Effects

Nausea and Vomiting: Stick to simple meals. Avoid eating heavily rich
or spicy food. Stay hydrated. Consult your doctor if it persists for long or
worsens with time.

Headache:

Take some rest, in a quiet place and avoid using mobile phones and other
electronic devices for a while. Drinking water as inadequate hydration may
worsen your headache. If symptoms persist, contact your doctor.

Warning & Precautions

!### Pregnancy

RCINis not recommended for use in women who are pregnant and/or planning
pregnancy as it can affect the growth of your unborn baby and may cause
complications to the mother and baby after birth.

Also, RCIN may result in the ineffectiveness of oral contrace
physical methods of contrace
consult your doctor before taking RCIN.

!### Breastfeeding

RCIN is not recommended to be taken by nursing women since it may pass to the
baby through mother’s milk. Consult your doctor before taking RCIN.

!### Driving and Using Machines

It is not recommended to drive and use heavy machinery after taking RCIN as it
might make you feel dizzy or faint. It is recommended to take RCIN only after
consultation with the doctor.

!### Kidney

RCIN must be taken with caution if you are diagnosed with any kidney disease.
Consult your doctor before taking RCIN.

!### Liver

RCIN must be taken caution if you are diagnosed with any disease of the liver.
Consult your doctor before taking RCIN.

!### Allergy

It is not recommended to take RCIN if you are allergic to Rifampicin and/or any
other drug present in RCIN.

Others

RCIN is not recommended for use if you:

• have yellowish tinge to eyes and skin which may be indicative of jaundice

Before taking RCIN, inform your doctor if you:

• are diagnosed with diabetes (elevated level of sugar in blood)
• are underweight and/or malnourished
• are diagnosed with a blood disorder called Porphyria characterized by the appearance of purple colored rash on skin
• are prone to bleeding and/or bruising
• wear contact lenses
• have deficiency of Vitamin K
• if symptoms of tuberculosis return or get worse
• have hypoprothrombinemia (deficient clotting factor)

Use in Pediatrics: RCIN must be taken in caution in children below 2
years of age. Consult your doctor before taking it as they can decide the
correct and required dosage, frequency and strength of RCIN based on age,
disease condition and body weight of the child.

Use in Geriatrics: RCIN must be taken in caution in elderly patients
(above the age of 65 years). Consult your doctor before taking RCIN.

Interactions

A. Drug-Drug Interactions:

Before taking RCIN, inform your doctor if you are taking any of the following
medicine:

• medicines used to manage HIV infection (Ex. saquinavir, ritonavir)
• medicines used to manage indigestion such as antacids (Ex. aluminium hydroxide, magnesium carbonate)
• other medicines used to manage tuberculosis (Ex. P-Aminosalicylic Acid)
• medicines used to thin the blood (Ex. clopidrogel, warfarrin)
• medicines used to lower cholesterol (Ex. atorvastatin, rosuvastatin)
• medicines for heart problems or to control your heartbeat (Ex. atenolol, bisprolol), lower the blood pressure (Ex. diuretics like eplerenone)
• medicines used to manage thought disorders (Ex. antipsychotics like haloperidol), reduce anxiety (Ex. hypnotics-lorazepam), to induce sleep (Ex. barbiturates-phenobarbital), manage depression (Ex. amitriptyline)
• medicines used to manage epilepsy (Ex. phenytoin), disease of motor neurons (Ex. riluzole)
• medicines used to manage various viral infections (Ex. indinavir, telaprevir, amprenavir, nelfinavir, atazanavir, lopinavir, neviparine, daclatasvir, simeprevir, sofosbuvir and telaprevir)
• medicines used to manage fungal diseases (Ex. ketoconazole, clotrimazole), bacterial infections (Ex. amoxicillin, cephalosporin), tapeworm infections (Ex. praziquantel)
• medicines used to lower the immune system response (Ex. ciclosporin, tacrolimus, sirolimus)
• medicines used to manage pneumonia (Ex. atovaquone)
• medicines used for contrace
• medicines used to manage cancer (Ex. imatinib, irinotecan, ethinyloestradiol, levonorgestrel or dydrogesterone), for breast cancer or endometriosis (Ex. tamoxifen, gestrinone, toremifene)
• medicines used to manage thyroid gland problems (Ex. levothyroxine)
• medicines used to manage gout and other pains (Ex. aspirin, etoricoxib, codeine, morphine, fentanyl, pethidine, etoricoxib, aspirin and indomethacin)
• medicines used to manage inflammation in the body such as corticosteroids (Ex. hydrocortisone, betamethasone and prednisolone)
• medicines used during withdrawal from heroin (Ex. methadone)
• medicines used to manage diabetes (Ex. metformin)
• medicines used before surgery to relax the mind and body (Ex. halothane)
• medicines used for nausea (Ex. ondansetron, aprepitant)
• medicines used for malaria (Ex. quinine)
• medicines used to manage difficulty breathing and wheezing sound (Ex. theophylline)

Overdosage:

If you or anyone else accidentally took too much of RCIN, visit the nearby
hospital or consult your doctor immediately. Signs and symptoms of overdosage
are feeling sick (nausea) along with vomiting and pain in abdomen, increased
itch (pruritus), headache and increased lethargy, feeling of drowsiness,
swelling of the face, eyes or eyelids, fast or uneven heartbeat, dizziness, fits
and heart attack.

Synopsis

Drug	:	Rifampicin
Pharmacological Category	:	Antibacterial
Therapeutic Indication	:	Bacterial infections
Dosage Forms	:	Syrup, Capsule, Tablet, Suspension

More Information

• Keep RCIN out of reach of children
• Keep RCIN away from heat
• Keep it below 25°C

FAQs About RCIN

What is RCIN used for? RCIN is used to manage bacterial infections such
as tuberculosis (affects the lungs), legionnaires disease (lung inflammation),
brucellosis (infection spreading from
lesions and nerve damage) and serious staphylococcal infections. It also manages
the infections caused by Haemophilus influenzae and Neisseria meningitides (who
are the carriers but do not show the symptoms), thereby managing and managing
the onset of flu and meningitis.

How does RCIN work? RCIN works by managing protein synthesis and
interfering with the enzymes present in the bacteria causing its death. This
results in a reduction in the count of infection-causing bacteria, thereby
managing bacterial infections.

When should I not take RCIN? RCIN is not recommended to be taken if you
are allergic to Rifampicin and/or any other constituent of RCIN, have yellowish
tinge to eyes and skin which may be indicative of jaundice and/or are diagnosed
with HIV infection.

C
heavy machinery after taking RCIN as it might make you feel dizzy or faint. It
is recommended to take RCIN only after consultation with the doctor.

Can RCIN be takenwith Vitamin D? Taking RCIN with Vitamin D will
decrease the effect of Vitamin D. Inform your doctor if you are taking this
medicine as the dose will be adjusted accordingly.

Useful Diagnostic Tests

• Liver Function Test (LFT)
• Complete Blood Count (CBC)
• Blood Glucose Level