PRUF TABLET 10'S

Introduction About PRUF

PRUF contains Flupirtine which belongs to a group of medicines called Nonopioid,
Non-NSAID analgesics. It is used in the management of acute and chronic pain
(such as primary headache, tumor pain, menstrual cramps, pain after
traumatologic/orthopaedic operations and injuries and painful increased muscle
tone of the posture and motor muscles).

PRUF is not recommended for use in patients with liver problems. Before taking
PRUF, inform your doctor if you have kidney disease, myasthenia gravis, had or
have a history of tinnitus (ringing in the ears) or if you are allergic to
Flupirtine. PRUF is not recommended for use in pregnant and breast-feeding women
unless clearly advised by the doctor.

PRUF is not recommended for use in children and adolescents (below 18 years of
age) unless deemed necessary and it should be used with caution in elderly
patients, especially in patients with kidney problems. The most common side
effects of taking PRUF are fatigue, dizziness, heartburn, nausea, vomiting, dry
mouth, constipation and diarrhea. Consult your doctor if any of the side effects
worsen.

Uses Of PRUF

• Manage acute and chronic pain (such as primary headache, tumor pain, menstrual cramps, pain after traumatologic/orthopaedic operations and injuries and painful increased muscle tone of the posture and motor muscles)

How PRUF Works

PRUF works by managing the transmission of pain signals by blocking neuronal
excitability and reducing the calcium influx into the cells that is responsible
for the sense of pain and inflammation produced at the site of injury and damage
and hence it is useful in providing relief from pain, including that is
associated with muscle tension.

How to use PRUF

Take PRUF as advised by your physician. Swallow the medicine with a glass of
water and do not chew or crush the medicine. Your doctor will decide the correct
dose and duration for you depending upon your age and body weight.

Side Effects Of PRUF

Common

• Fatigue
• dizziness
• Heartburn
• Nausea
• vomiting
• Diarrhea
• stomach upset
• bloating and pain
• Constipation
• Sleep problems
• Increased sweating
• Loss of appetite
• dry mouth
• Tremors
• headache
• Restlessness, nervousness

Uncommon

• Confusion
• Vision problems
• Skin rash, hives and itching

Rare

• Elevated levels of liver enzymes in blood

Stop taking PRUF and contact your doctor immediately if you experience any of
the following side effects:

• Signs of hepatic encephalopathy (forgetfulness, confusion, breath with a sweet or musty odor, shaking of the hands or arms, disorientation and slurred speech)
• Signs of drug-induced hepatitis (stomach pain, tiredness, fever, nausea, vomiting, dark urine and pale-colored stools)

How To Manage Side Effects

!### Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and
drink plenty of water. Exercise more regularly. If the symptom does not improve,
consult your doctor.

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating
high-fat or spicy foods. Try to avoid taking any medicine on your own to manage
diarrhea and consult your doctor if the symptom gets worse.

!### Dry Mouth

Sip water regularly and other sugar free liquids. Do not use mouthwashes that
contain alcohol because they can make your mouth dry, use mouthwash that is used
only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco
products. Consult your doctor if the symptom does not improve.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

!### Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried
or spicy foods. Do not lie down or sleep immediately after eating. Inform your
doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

Monitoring requiredPRUF is not recommended during pregnancy unless considered clearly necessary.
Consult your doctor before taking PRUF.

!### Breastfeeding

Monitoring requiredPRUF is not recommended in breastfeeding women unless considered clearly
necessary. Consult your doctor before taking PRUF.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel dizzy or sleepy after taking
PRUF.

!### Alcohol

Consult your doctorAvoid consuming alcohol while taking PRUF as it may increase the risk of liver
problems.

!### Kidney

Use with CautionPRUF should be used with caution in patients with kidney diseases. Consult your
doctor for advice before taking PRUF.

!### Liver

ContraindicatedPRUF is not recommended for use in patients with liver problems. Consult your
doctor for advice before taking PRUF.

!### Allergy

ContraindicatedPRUF is not recommended for use if you are allergic to flupirtine.

!### Use In Pediatrics

ContraindicatedPRUF is not recommended for use in children and adolescents (below 18 years of
age) unless deemed necessary. Consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionPRUF should be used with caution in elderly patients, especially in patients
with any kidney problems. Consult your doctor for advice before taking PRUF.

Others

Before taking PRUF, inform your doctor if you:

• Have myasthenia gravis
• Had or have a history of tinnitus (ringing in the ears)

Interactions

A. Drug-Drug interactions:

Before taking PRUF, inform your doctor, if you are taking any of the following
medicines:

• Medicines that manage or manages blood clot (Ex. warfarin, dicumarol)
• Paracetamol (used to reduce fever and inflammation)
• Carbamazepine (used to manage epilepsy)
• Diazepam (used to manage anxiety and alcohol withdrawal)

Overdosage:

If you or anyone else accidentally takes too much of PRUF, consult your doctor
immediately or visit the nearby hospital.

Synopsis

Drug	:	Flupirtine
Pharmacological Category	:	Triaminopyridine
Therapeutic Indication	:	Pain Relief
Dosage Forms	:	Tablet, Capsule

More Information

Storage

• Keep PRUF out of reach of children
• Store at room temperature

FAQs About PRUF

Q: What is PRUF used for?

A: PRUF is used in the management of acute and chronic pain (such as primary
headache, tumor pain, menstrual cramps, pain after traumatologic/orthopaedic
operations and injuries and painful increased muscle tone of the posture and
motor muscles).

Q: What common side effects are seen with PRUF?

A: The most common side effects of taking [GBNKEYWORD are fatigue, dizziness,
heartburn, nausea, vomiting, dry mouth, diarrhoea, constipation, diarrhea,
stomach upset, bloating and pain, loss of appetite, tremor, headache, increased
sweating, sleep problems and restlessness. Consult your doctor if any of the
side effects worsen.

Q: How does PRUF work?

A: PRUF works by managing the transmission of pain signals by blocking neuronal
excitability and reducing the calcium influx into the cells that is responsible
for the sense of pain and inflammation produced at the site of injury and
damage, and hence it is useful in providing relief from pain, including that is
associated with muscle tension.

Q: Can PRUF be used in pregnant women?

A: PRUF is not recommended for use in pregnant women unless clearly advised by
the doctor. Consult your doctor before taking PRUF if you are pregnant or
planning to get pregnant.

Q: Is PRUF safe to use in patients with kidney diseases?

A: PRUF should be used with caution in patients with kidney diseases. Your
doctor may regularly monitor your kidney function before and during management
with PRUF to manage the risk of kidney damage. Consult your doctor for advice
before taking PRUF.

Useful Diagnostic Tests

• Liver function test
• Kidney function test