PRONOMORE 5mg Tablet 1's

Introduction About PRONOMORE 5MG TABLET

PRONOMORE 5MG TABLET contains Norethisterone, which belongs to a group of
medicines called Progestogens. It is used to manage heavy menstrual bleeding or
abnormal uterine bleeding (that occurs due to hormonal imbalance), painful
periods, irregular periods or periods that are more frequent than normal
(polymenorrhoea), premenstrual tension, endometriosis (abnormal growth of
endometrial tissue of the uterus that causes pain and menstrual irregularities),
metriopatheias haemorrhagia (intermenstrual bleeding) and breast cancer. It is
also used to delay the menstrual cycle.

PRONOMORE 5MG TABLET is not recommended for use in patients with pulmonary
embolism (blood clots in the lung), liver disease, heart attack (myocardial
infarction) or angina and deep vein thrombosis. PRONOMORE 5MG TABLET should be
used with caution in patients with asthma, kidney disease, fits, and migraine
headaches.

PRONOMORE 5MG TABLET is not recommended for use during pregnancy as it may
affect the developing baby. Inform your doctor if you have had repeated
miscarriages. PRONOMORE 5MG TABLET should be used with caution in breastfeeding
women as it may pass through the breast milk. If you experience mood changes and
depressive symptoms, contact your doctor as soon as possible.

The most common side effects of taking PRONOMORE 5MG TABLET are irregular
bleeding, heavy menstruation, spotting between menstrual cycles, delayed or not
having a menstrual cycle, stomach discomfort, nausea, vomiting, breast
tenderness, headache, and dizziness. Contact your physician if the symptoms
worsen

Uses Of PRONOMORE 5MG TABLET

PRONOMORE 5MG TABLET manages and manages:

• heavy periods
• painful periods
• irregular periods
• increased frequency of periods
• premenstrual tension
• endometriosis (a disease where the tissue lining the uterus, grows outside the uterus)
• breast cancer
• metropathia
• haemorrhagia (intermenstrual bleeding)
• abnormal uterine bleeding
• breast cancer
• to delay the next periods

How PRONOMORE 5MG TABLET Works

PRONOMORE 5MG TABLET inhibits the release of pituitary hormones that are
responsible for the release of female hormones (such as oestrogen and
progesterone) and thereby suppressing ovulation. This action modifies the lining
of the endometrium and thus ceases bleeding in menstrual abnormalities in cancer
PRONOMORE 5MG TABLET may act by pituitary inhibition or by direct action on
tumour deposits.

How to use PRONOMORE 5MG TABLET

Follow the instructions given by your doctor. Take PRONOMORE 5MG TABLET as
advised according to your symptoms and disease severity. Swallow the whole
tablet with a glass of water.

Side Effects Of PRONOMORE 5MG TABLET

Common

• irregular bleeding, heavy menstruation
• spotting between menstrual cycles
• delayed or not having a menstrual cycle
• stomach discomfort, nausea, vomiting
• breast tenderness
• headache and dizziness

Rare

Stop taking PRONOMORE 5MG TABLET and contact your doctor immediately if you
experience any of the following side effects:

• yellowing of the skin or white area of the eyes (jaundice)
• migraine headache for the very first time (a headache that usually restricts itself to one side of your head)
• high blood pressure
• symptoms of severe allergic reaction such as itchy skin rash, swelling of the face or tongue, hands or feet causing wheezing, difficulty breathing or feeling faint
• symptoms of a blood clot in the lungs include a sudden, severe, sharp pain in the chest, coughing up blood, shortness of breath, rapid heartbeats
• symptoms of a blood clot in the brain (stroke) include unusually severe or long headache, change in sight, difficulty speaking, collapsing, or fainting, and weakness or paralysis of any part of your body
• symptoms of a deep-vein thrombosis such as severe pain, tenderness or swelling in your calf, ankle or foot, purplish discolouration of the skin of the leg and red or warmth skin

How To Manage Side Effects

Nausea, vomiting:

Take the medicine with or just after a meal. Stick to simple meals. Avoid eating
oily or spicy foods. Contact your doctor if nausea and vomiting get worse.

Headache:

Rest and relax. Apply a pain-relieving balm to your forehead if needed. Do not
consume alcohol. Contact your doctor if your headache does not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if
you feel dizzy. Avoid alcohol consum
your doctor if the dizziness worsens.

Stomach pain:

Try to rest and relax. Eat small meals but take them frequently. Keep a heating
pad on your stomach. Contact your doctor if the stomach pain does not improve.

Warning & Precautions

!### Pregnancy

PRONOMORE 5MG TABLET is not recommended for use during pregnancy and if you have
a history of Idiopathic jaundice during pregnancy or an itchy rash or blisters
on the abdomen known as pemphigoid gestationis (rare autoimmune skin disorder in
pregnancy) and PRONOMORE 5MG TABLET should be used with caution in patients with
a history of repeated miscarriages. Contact your doctor before taking PRONOMORE
5MG TABLET.

!### Breastfeeding

PRONOMORE 5MG TABLET should be used with caution in breastfeeding women as it
may pass through the breast milk. Contact your doctor before taking PRONOMORE
5MG TABLET.

!### Driving and Using Machines

PRONOMORE 5MG TABLET does not affect the ability to drive or operate machinery.

!### Kidney

PRONOMORE 5MG TABLET should be used with caution in patients with kidney
disease. Contact your doctor before taking PRONOMORE 5MG TABLET.

!### Liver

PRONOMORE 5MG TABLET should be used with caution in patients with liver disease.
Contact your doctor before taking PRONOMORE 5MG TABLET.

!### Allergy

Do not use PRONOMORE 5MG TABLET if you are allergic to norethisterone, similar
other hormone medicines, or any other ingredients in the medicine.

!### Lungs

PRONOMORE 5MG TABLET is not recommended for use in patients who have or had a
pulmonary embolism (blood clots in the lung) and should be used with caution in
patients with asthma. Contact your doctor before taking PRONOMORE 5MG TABLET.

!### Heart Disease

PRONOMORE 5MG TABLET is not recommended for use in patients with active or
recent angina (chest pain) or heart attack. Contact your doctor before
takingPRONOMORE 5MG TABLET.

Others

PRONOMORE 5MG TABLET is not recommended for use if you have:

• blood disorders like porphyria
• clotting disorders like deep vein thrombosis or a family history of the same
• pruritis (a condition with severe generalised itching of the body)
• undiagnosed vaginal bleeding (not a period)

Before taking PRONOMORE 5MG TABLET tell your doctor if you have:

• epilepsy
• migraine headache
• are very overweight
• systemic lupus erythematosus.
• a blood clot in the veins
• are unable to move for long periods (Ex. after an operation)
• serious injury
• have major surgery or are going to have an operation (particularly abdominal or orthopaedic surgery to the lower limbs)
• blood tests (for liver function, thyroid function, and coagulation).
• vision impairment, bulging eyes, double vision
• depression

Interactions

A. Drug-Drug Interactions:

• antiepile
• antibiotics ex. tetracyclines, co-trimoxazole, ampicillin, oxacillin (medicines used for bacterial infections)
• medicines used for tuberculosis (rifampicin, rifabutin)
• antiviral medicines for management of HIV (ritonavir, nelfinavir, efavirenz)
• anticancer medicines
• aminoglutethimide (used in Cushing’s syndrome)
• ciclosporin (immunosuppressants or medicines used to manage rejection of a transplanted organ)
• nonsteroidal anti-inflammatory drugs NSAID’s (medicines used for pain)
• medicines for managing high blood pressure (amlodipine, captopril, atenolol, telmisartan)
• st. john’s wort (medicines used to manage depression)

Overdosage:

If you or anyone else accidentally took more of PRONOMORE 5MG TABLET, contact
your doctor immediately or visit a nearby hospital immediately if the symptoms
worsen. The symptoms may include nausea, vomiting, breast enlargement and
vaginal bleeding.

Synopsis

Drug	:	Norethisterone
Pharmacological Category	:	Progestogens
Therapeutic Indication	:	Menstrual disorders and breast cancer
Dosage Forms	:	Tablet

More Information

• Keep PRONOMORE 5MG TABLET below 25°C
• Keep PRONOMORE 5MG TABLET out of sight and reach from children

FAQs About PRONOMORE 5MG TABLET

Can PRONOMORE 5MG TABLET affect the regular menstrual cycle?

PRONOMORE 5MG TABLET is a synthetic form of the hormone progesterone. Rather
than allowing for the natural fall in progesterone during your period, PRONOMORE
5MG TABLET keeps your progesterone levels high. This delays the shedding of your
womb lining and the period.

When will my menstrual cycle start after taking PRONOMORE 5MG TABLET?

Your doctor will advise you when to take PRONOMORE 5MG TABLET and for how long.
You'll usually be prescribed 3 PRONOMORE 5MG TABLET tablets a day, starting 3 to
4 days before you expect your period to begin. Your period should arrive 2 to 3
days after you stop taking the PRONOMORE 5MG TABLET.

How long will PRONOMORE 5MG TABLET take to stop bleeding?

If a period is very heavy or prolonged, your doctor may advise you to take
PRONOMORE 5MG TABLET 5mg three times daily for 10 days. Bleeding will usually
stop within 24-48 hours of starting management.

What happens if I take PRONOMORE 5MG TABLET too late?

It is important to take PRONOMORE 5MG TABLET three days before your menstrual
cycle. If you take PRONOMORE 5MG TABLET too late, it may delay your menstrual
cycle.

Can PRONOMORE 5MG TABLET cause mood depression?

Yes, PRONOMORE 5MG TABLET may cause depressed mood, acne, breast tenderness,
fluid retention and loss of libido. Contact your doctor if you get any of the
side effects.

Useful Diagnostic Tests

• Complete blood count
• Thyroid functions
• HCG
• Pap smear