PREDKAIN 4 Tablet 10's

Introduction About PREDKAIN 4 TABLET

PREDKAIN 4 TABLET is used to manage various adrenal gland problems, including
adrenal insufficiency, congenital adrenal hyperplasia, and nonsuppurative
thyroiditis. It is also effective in managing autoimmune and inflammatory
conditions affecting different parts of the body, such as rheumatoid arthritis,
ankylosing spondylitis, systemic lupus erythematosus, psoriasis, o
uveitis, asthma, and certain blood disorders like leukemia. Additionally, it
helps manage inflammatory bowel diseases like Crohn's disease and ulcerative
colitis, as well as tuberculous meningitis in the brain.

This medication is also prescribed for managing severe allergic reactions,
including drug-induced hypersensitivity, atopic dermatitis, allergic
conjunctivitis, and allergic rhinitis. It can prevent graft rejection after
organ transplantation and support kidney health by reducing protein loss in the
urine or increasing urine output in conditions like nephrotic syndrome.

It contains a medicine called Methylprednisolone which belongs to the group of
medicines called Corticosteroids.

Take PREDKAIN 4 TABLET as advised by your physician. Do not stop taking PREDKAIN
4 TABLET or reduce the dose of methylprednisolone without consulting your doctor
as it may lead to unpleasant withdrawal symptoms, especially if you are taking
higher dose of methylprednisolone.

Before taking PREDKAIN 4 TABLET inform your doctor if you any viral infections,
or any liver, kidney or heart problems. You must also inform your doctor if you
have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut
inflammation, muscle problems, osteoporosis, any types of tumors or cancer in
the body, depression or any other forms of mental illness.

It should be used in pregnant or breastfeeding women only if it is considered
necessary by the physician. Avoid drinking grapefruit juice or eating grapefruit
while taking PREDKAIN 4 TABLET as it may lead to unwanted side effects.

The most common side effects of taking PREDKAIN 4 TABLET are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

You must also inform your doctor if you experience severe depression with
suicidal thoughts or severe stomach pain with blood-stained stools or vomit.

Uses Of PREDKAIN 4 TABLET

It is used to manage the following disease conditions:

• adrenal insufficiency and its associated conditions
• bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
• skin and collagen disorders (Ex. systemic lupus erythematosus, psoriasis)
• eye problems (Ex. o
• respiratory tract diseases (Ex. asthma, tuberculosis)
• blood cancer (leukemia), lymph cancer (lymphoma)
• problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
• brain problems (Ex. tuberculous meningitis)
• drug induced hypersensitivity reactions
• allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

• reduce the risk of graft rejection following organ transplantation
• improve urine output or reduces protein loss in urine among patients having nephrotic syndrome

How PREDKAIN 4 TABLET Works

PREDKAIN 4 TABLET is a corticosteroid medicine with anti-inflammatory and immune
suppressant properties. It boosts your body with sufficient corticosteroid
levels (cortisol, aldosterone) during deficient conditions and helps your body
to function properly.

It also reduces the release of certain chemicals (prostaglandins) in the body
that causes inflammation. It manages graft rejection by suppressing the immune
functions and protects your kidney from damage in patients with kidney problems.

How to use PREDKAIN 4 TABLET

• Take PREDKAIN 4 TABLET as advised by your physician.
• Swallow the medicine with a glass of water.
• Do not crush or chew the medicine.
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
• Do not stop taking PREDKAIN 4 TABLET without consulting your doctor.

Side Effects Of PREDKAIN 4 TABLET

Like all medications, this medicine may cause side effects, although they do not
occur in everyone.

Common Side Effects of PREDKAIN 4 TABLET:

• high blood pressure (causing headache, or a general feeling of being unwell)
• swelling of body parts
• muscle cramps, weakness or wasting
• cataract, blurred vision
• slowed growth in children
• moon shaped face (Cushingoid facies)
• feeling sad, mood changes, m
• problems in sleeping
• difficulty in thinking, confusion, loss of memory, hallucinations
• fear or frightening thoughts
• acne, poor wound healing
• skin thinning

Contact your doctor immediately if you experience any of the following side
effects while undergoing therapy with PREDKAIN 4 TABLET:

• signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
• signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
• increased infections causing fever or a general feeling of being unwell
• signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
• signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
• signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
• signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
• thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
• feeling depressed, suicidal thoughts
• blurred vision or other visual disturbances

Warning & Precautions

!### Pregnancy

Monitoring requiredPREDKAIN 4 TABLET should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor before taking PREDKAIN
4 TABLET if you are pregnant, think you may be pregnant or planning to have a
baby.

!### Breastfeeding

Monitoring requiredPREDKAIN 4 TABLET should be used in breastfeeding women only if it is considered
necessary by the physician.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness
after taking PREDKAIN 4 TABLET.

!### Alcohol

Consult your doctorAvoid consum
feel drowsier.

!### Kidney

Use with CautionPREDKAIN 4 TABLET should be used with caution in patients with kidney diseases.

!### Liver

PREDKAIN 4 TABLET should be used with caution in patients with liver diseases.

!### Allergy

ContraindicatedDo not take PREDKAIN 4 TABLET if you are allergic to Methylprednisolone.

Lungs

ContraindicatedPREDKAIN 4 TABLET is not recommended for use in patients with fungal infection
of the lungs.

!### Heart Disease

Use with CautionPREDKAIN 4 TABLET should be used with caution in patients with heart problems
(such as recent heart attack or heart failure).

!### Use In Pediatrics

Consult your doctorPREDKAIN 4 TABLET should be used in children and adolescents (aged below 18
years) only if prescribed by the physician.

!### Use In Geriatrics

Use with CautionPREDKAIN 4 TABLET should be used with caution in elderly patients (aged 65 years
or above).

Others

PREDKAIN 4 TABLET is not recommended for use if you:

• have serious unmanageed fungal infections (Ex. infection of lungs or esophagus)
• got vaccinated recently or scheduled for any upcoming vaccinations

Before taking PREDKAIN 4 TABLET, inform your doctor if you:

• have or had been in contact with someone who has chickenpox, measles or shingles
• have or ever had severe depression or bipolar disorder
• have a family history of mental illness
• have diabetes or a family history of diabetes
• have fits
• have or have a family history of glaucoma
• have viral or fungal infections of the eyes
• have hypertension (high blood pressure)
• have underactive thyroid gland (hypothyroidism)
• have inflammation of pancreatitis or gut lining (peritonium)
• have scleroderma (an autoimmune disorder causing skin tightness, cold extremities, joint pain and heart burn)
• have Kaposi’s sarcoma (a type of skin cancer)
• have any muscle problems (Ex. myasthenia gravis)
• have osteoporosis (brittle bones)
• have pheochromocytoma (a rare tumor of the adrenal glands)
• have skin abscess
• have stomach ulcer or other serious stomach or intestinal problems
• have thrombophlebitis (clots in veins)
• have or had tuberculosis
• have Cushing’s disease
• have brain injury due to trauma
• have any unusual stress
• are scheduled for any upcoming surgery (including dental surgery)

Interactions

A. Drug - Drug interactions:

Before taking PREDKAIN 4 TABLET, inform your doctor if you are taking any of the
following medicines such as:

• acetazolamide (a medicine used to manage glaucoma or edema)
• aminoglutethimide or cyclophosphamide (used for managing cancer)
• anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
• anti-cholinergic medicines used to manage myasthenia gravis (such as distigmine and neostigmine)
• antibacterials (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
• anti diabetics (Ex. metformin, glipizide)
• aprepitant or fosaprepitant (antiemitics)
• non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
• antiepile
• carbenoxolone and cimetidine (antiulcer agents)
• ciclosporin, tacrolimus (immunosuppressants)
• Cardiovascular agents (such as digoxin, diltiazem or mibefradil)
• oral contrace
• medicines used to manage HIV infection (such as ritonavir, indinavir, cobicistat)
• Antifungals (such as ketoconazole, amphotericin B, itraconazole)
• muscle relaxants (Ex. pancuronium or vecuronium)
• diuretics (used to manage edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
• medicines used to manage asthma (such as aminophylline, salmeterol, formoterol)
• rifampicin and rifabutin (Antituberculosis)
• live vaccines

B. Drug - Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while taking PREDKAIN 4
TABLET as it may lead to unwanted side effects.

Overdosage:

If you or anyone else accidentally took more PREDKAIN 4 TABLET, consult your
doctor immediately or visit the nearby hospital straight away.

Synopsis

Drug	:	Methylprednisolone
Pharmacological Category	:	Synthetic Glucocorticoids
Therapeutic Indication	:	Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Manage graft rejection, Proteinuria
Dosage Forms	:	Tablet, Injection, Cream

More Information

Storage

• Keep PREDKAIN 4 TABLET out of reach of children
• Store PREDKAIN 4 TABLET at room temperature

FAQs About PREDKAIN 4 TABLET

Q: What is PREDKAIN 4 TABLET used for?

A: PREDKAIN 4 TABLET is a corticosteroid medicine used to manage adrenal
insufficiency. It can also be used to manage drug induced hypersensitivity
reactions, allergic reactions and various inflammatory auto-immune disease
conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc.
It also helps in management of graft rejection following organ transplantation,
reduces flare-ups of multiple sclerosis and increases urine output among
patients with kidney problems.

Q: How to take PREDKAIN 4 TABLET?

A: Swallow PREDKAIN 4 TABLET with a glass of water. Do not crush or chew the
medicine.

Q: Is PREDKAIN 4 TABLET a steroid?

A: Yes. PREDKAIN 4 TABLET is synthetic corticosteroid used to manage problems of
adrenal gland and various allergic, hypersensitivity and inflammatory autoimmune
disease conditions.

Q: What are the most common side effects of PREDKAIN 4 TABLET?

A: The most common side effects of receiving PREDKAIN 4 TABLET are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

Q: Can PREDKAIN 4 TABLET make you feel high?

A: Yes. PREDKAIN 4 TABLET may make you feel high. Such symptoms may disappear
once the therapy has been stopped. However, consult your doctor if it bothers
you.

Q: How does PREDKAIN 4 TABLET works?

A: PREDKAIN 4 TABLET boosts your body with sufficient corticosteroid levels and
helps your body to function properly. It also reduces the release of certain
chemicals in the body that causes inflammation. It also manages graft rejection
by suppressing the immune functions and protects your kidney from damage in
patients with kidney problems.

Q: How long will it take for PREDKAIN 4 TABLET to control my disease?

A: The time taken by PREDKAIN 4 TABLET to control the disease may vary from
person-to-person depending upon the dose of methylprednisolone administered and
disease severity.

Q: Is PREDKAIN 4 TABLET safe to use in diabetic patients?

A: PREDKAIN 4 TABLET may alter the blood sugar levels in your body. Therefore,
it is necessary to inform your doctor if you have diabetes before receiving
PREDKAIN 4 TABLET as a precaution.

Q: Who should not take PREDKAIN 4 TABLET?

A: PREDKAIN 4 TABLET is not recommended for use in patients with serious fungal
infections, brain swelling due to malaria or brain injury or stroke. It is also
not suitable for use in patients who got vaccinated recently.

Q: Can I take PREDKAIN 4 TABLET daily?

A: Your doctor will evaluate your health condition and suggests whether can you
receive PREDKAIN 4 TABLET every day or not.

Q: Can PREDKAIN 4 TABLET be used in children?

A: PREDKAIN 4 TABLET should be used in children and adolescents (aged below 18
years) only if prescribed by the physician. Therefore, consult your doctor for
advice before receiving it.

Q: Will PREDKAIN 4 TABLET alter the effects of birth control pills?

A: PREDKAIN 4 TABLET may reduce the effects of birth control pills. Therefore,
try to avoid taking birth control pills along with PREDKAIN 4 TABLET. Consult
your doctor for advice.

Q: Can PREDKAIN 4 TABLET be used in pregnant women?

A: PREDKAIN 4 TABLET should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor before receiving
PREDKAIN 4 TABLET if you are pregnant, think you may be pregnant or planning to
have a baby.

Useful Diagnostic Tests

• Absolute Eosinophil Count
• Anti-Nuclear Antibody
• Anti-ds-DNA Antibody
• Anti-ds-DNA Antibody-IFA
• Peripheral Smear Examination
• Total IgE