Ornoxin Tablet 10'S

Introduction About ORNOXIN TABLET

ORNOXIN TABLET is a combination of Ornidazole and Ofloxacin which belongs to the
group of medicines called Antibiotics. ORNOXIN TABLET is used to manage various
bacterial infections involving the blood (such as se
meningitis), lungs (such as pneumonia, bronchitis), ear and nose (such as
sinusitis), urinary tract (such as cystitis), genital infections (including both
the male and female genital organs), wound (post-operative infections),
reproductive system (such as puerperal sepsis, se
and stomach (such as peritonitis). ORNOXIN TABLET is also used as prophylaxis to
manage bacterial infections during surgical interventions (particularly
involving the colon and in gynaecological operations).

Before initiating the management with ORNOXIN TABLET, your doctor may recommend
you take relevant medical tests to understand your existing condition and to
properly use this medicine. Before taking ORNOXIN TABLET inform your doctor if
have heart disease (such as irregular heartbeat, valve disorder, poor heart
function), kidney diseases (such as kidney failure or kidney injury),
inflammation of the intestine, fits/seizure, autoimmune disease (such as
multiple sclerosis), muscle-weakening diseases (such as myasthenia gravis), weak
tendons (tendonitis, tendon rupture, rotator cuff), nerve pain (neuropathy),
liver disease, psychiatric illness or emotional imbalances.

ORNOXIN TABLET is not recommended for use in pregnant and breastfeeding women.
ORNOXIN TABLET is not recommended for use in children and adolescents (under 18
years of age) and it should be used with caution in elderly patients. The common
side effects of taking ORNOXIN TABLET are nausea, vomiting, diarrhea, headache,
itching and changes in taste sensation. Consult your doctor immediately if any
of the side effects worsen during or after management with ORNOXIN TABLET.

Uses Of ORNOXIN TABLET

It is used to manage bacterial infections such as:

• Lungs infections (Ex. pneumonia, bronchitis)
• Sinus infections
• Urinary tract infections
• Meningitis
• Se
• Puerperal sepsis, se
• Peritonitis
• Post-operative wound infections
• Gonorrhoea and some other genital infections (both the male and female genital organs)
• Prophylaxis during surgical interventions (particularly involving the colon and in gynaecological operations)

How ORNOXIN TABLET Works

ORNOXIN TABLET is a combination of Ornidazole and Ofloxacin where Ornidazole
works against the parasites and bacteria that live in the absence of oxygen by
generating harmful molecule which damages the DNA of the parasites and bacteria
and Ofloxacin is a quinolone antibiotic that works against the bacteria by
inhibiting the synthesis of bacterial DNA, hence helps to manage various
infections.

How to use ORNOXIN TABLET

Take ORNOXIN TABLET as directed by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. Your doctor will decide the
correct dose, duration and frequency of ORNOXIN TABLET for you depending on your
age, body weight and disease condition.

Side Effects Of ORNOXIN TABLET

Common

• Headache
• dizziness
• Nausea
• vomiting
• Diarrhea
• Itching
• Sleep problems
• External genital itching in women
• Vaginal inflammation
• Changes in taste sensation

Uncommon

• Stomach pain or discomfort
• Dry mouth
• Loss of appetite
• Fungal infection
• Agitation, restlessness
• Burning or irritation of the eye
• Cough and inflamed sore nose or throat
• Spinning sensation of the head (vertigo)

Rare

• Fast heartbeat
• Drowsiness
• Confusion, nightmare
• Decrease in blood sugar levels
• Depression or hallucination (feeling or hearing things not there)
• Changes in sensation of smell
• Shortness of breath or wheezing
• Excessive sweating
• Feeling faint, lightheadedness due to low blood pressure
• Hives
• Rash with pimples
• Pain or swelling around joints (tendonitis)
• Excessive sweating, hot flushes

Stop taking ORNOXIN TABLET and contact your doctor immediately if you experience
any of the following side effects:

• Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and other parts of the body, difficulty in breathing or wheezing, blisters on the skin, sore throat, fever, headache)
• Painful skin rashes with blisters and peeling or scaling of the skin in conditions such as steven-johnson syndrome and toxic epidural necrolysis
• Abnormal heartbeat
• Changes in behavior, psychosis, depression, hallucination, disorientation or fainting
• Impaired vision or hearing
• Severe fever, body chills or muscle pain
• Swelling or rupture of tendons
• Numbness or tingling sensation of the skin
• Abnormal bleeding
• Abnormal body movements like fits or seizure
• Severe loose stools or diarrhea
• Difficulty in passing urine or urine discoloration
• Loss of consciousness
• Abnormal body sugar level
• Pain, burning, numbness and/or weakness especially in the feet and legs or hands and arms which indicates nerve damage
• Stomach pain, itching, dark urine or yellowish discoloration of the skin and in the white part of the eye (jaundice)

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult your doctor
if the symptom did not improve.

!### Dry Mouth

Sip water regularly and other sugar free liquids. Do not use mouthwashes that
contain alcohol because they can make your mouth dry, use mouthwash that is used
only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco
products. Consult your doctor if the symptom does not improve.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to
be relaxed and stress free. Apply pain relieving balm on your forehead if
necessary. Consult your doctor if the symptom does not improve.

!### Nausea And Vomiting

Take ORNOXIN TABLET with or just after meals. Stick to simple meals. Avoid
eating oily, fried or spicy foods. Do not lie down or sleep immediately after
eating. Consult your doctor if the symptom does not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedORNOXIN TABLET is not recommended for use in pregnant women. Also, consult your
doctor if you are suspecting or planning for pregnancy before taking ORNOXIN
TABLET.

!### Breastfeeding

ContraindicatedORNOXIN TABLET is not recommended for use in breastfeeding women. Consult your
doctor for advice before taking ORNOXIN TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines after taking ORNOXIN TABLET if you feel
dizzy, tired, sleepy, temporary loss of consciousness, less alert, spinning
sensation of head, impaired vision, shivering, abnormal body movements and
seizure/fits.

!### Alcohol

ContraindicatedDo not consume alcohol while taking ORNOXIN TABLET as it may aggravate your
symptoms such as sleepiness, dizziness and eyesight problems.

!### Kidney

Use with CautionORNOXIN TABLET should be taken with caution in patients with kidney disease or
problems. Consult your doctor for advice before taking ORNOXIN TABLET.

!### Liver

Use with CautionORNOXIN TABLET should be taken with caution in patients with liver disease.
Consult your doctor for advice before taking ORNOXIN TABLET.

!### Allergy

ContraindicatedDo not take ORNOXIN TABLET if you are allergic to Ofloxacin or Ornidazole. Also,
inform your doctor if you are allergic to other quinolone antibiotics such as
ciprofloxacin, norfloxacin.

!### Heart Disease

Use with CautionORNOXIN TABLET should be taken with caution in patients with leaking heart
valves (heart valve regurgitation), endocarditis (infection of the heart),
irregular or slow heartbeat, family history of prolonged QT interval, weak heart
(heart failure), history of heart attack (myocardial infarction). Consult your
doctor for advice before taking ORNOXIN TABLET.

!### Use In Pediatrics

ContraindicatedORNOXIN TABLET is not recommended for use in children and adolescents under 18
years of age. Consult your child’s doctor for advice.

!### Use In Geriatrics

Use with CautionORNOXIN TABLET should be used with caution in elderly patients. Your doctor will
decide the dose, duration and frequency of ORNOXIN TABLET depending on the
severity of your existing condition and other comorbidity conditions.

Others

ORNOXIN TABLET is not recommended for use if you:

• Have epilepsy or at risk of fits
• Have any pre-exisiting central nervous system (CNS) disorders
• Have history of inflammation and swelling of the tendons (tendonitis) especially after the management with quinolone antibiotics such as ciprofloxacin, norfloxacin or nadifloxacin
• Are suffering from or have a family history of glucose-6-phosphate dehydrogenase deficiency (an inherited disorder that affects the red blood cells)

Before taking ORNOXIN TABLET, inform your physician if you:

• Have an enlargement or bulge of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm)
• Experienced a previous episode of aortic dissection (a tear in the aorta wall)
• Have a family history of aortic aneurysm or aortic dissection
• Have other risk factors or predisposing conditions (Ex. connective tissue disorders such as marfan syndrome or ehlers- danlos syndrome, turner syndrome, sjogren’s syndrome (an inflammatory autoimmune disease)
• Have vascular disorders such as takayasu arteritis, giant cell arteritis, behcet’s disease and high blood pressure or atherosclerosis, rheumatoid arthritis
• Have or ever had a history of mental illness
• Have salt imbalance in the blood (especially low level of potassium or magnesium in the blood)
• Illness of the nervous system called myasthenia gravis (muscle weakness)
• Are diabetic or suffer from low blood sugar
• Have due to urine tests for porphyrin (a pigment in the blood) or for opiates (strong painkillers)

Interactions

A. Drug-Drug interactions:

Before taking ORNOXIN TABLET, inform your doctor if you are taking any of the
following medicines:

• Antipsychotics such as olanzapine, clozapine (used to manage psychosis)
• Cyclosporin (used to manage organ rejection after transplant)
• Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide, pentoxifylline (used to manage irregular heart rhythm)
• Lithium or tricyclic antidepressants such as clomipramine, amitriptyline (used to manage depression)
• Macrolides such as erythromycin, clarithromycin, azithromycin (used to manage bacterial infection)
• Vecuronium bromide (used to relax muscles)
• Phenytoin, phenobarbital (used to manage epilepsy)
• Didanosine (used in the management of HIV infection)
• Furosemide (used to manage body fluid retention)
• Sucralfate, cimetidine (used to manage stomach ulcer)
• Antacids containing magnesium or aluminium (used for indigestion)
• Corticosteroids such as prednisolone, dexamethasone (used to manage inflammation)
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or diclofenac (used to pain and inflammation)
• Theophylline (used to manage asthma)
• Insulin, glibenclamide (used to manage diabetes)
• Probenecid (used to manage gout)
• Methotrexate (used for rheumatism)
• Warfarin, acenocoumarin, phenprocoumon (used to manage or manage blood clot)
• Medicines or dietary supplements that contain iron (for anemia) or zinc
• Herbal medicines

Overdosage:

If you or anyone else accidentally takes too much of ORNOXIN TABLET, consult
your doctor immediately or visit the nearby hospital. Overdosage symptoms of
ORNOXIN TABLET include confusion, dizziness, loss of consciousness, seizure or
fit and nausea.

Synopsis

Drug	:	Ornidazole, Ofloxacin
Pharmacological Category	:	Nitroimidazole, Fluoroquinolones
Therapeutic Indication	:	Various bacterial infections
Dosage Forms	:	Tablet, Capsule, Infusion, Injection, Syrup, Oral Suspension

More Information

Storage

• Keep ORNOXIN TABLET out of reach from children
• Store ORNOXIN TABLET at room temperature

FAQs About ORNOXIN TABLET

Q: Can [GBBNKEYWORD] be used by pregnant women?

A: ORNOXIN TABLET is not recommended for use in pregnant women. However, consult
your doctor for advice before taking ORNOXIN TABLET, as your doctor may outweigh
the risks and benefits during life-threatening situations for use.

Q: Does ORNOXIN TABLET cause diarrhea?

A: Yes, ORNOXIN TABLET may cause side effects like diarrhea. Drink lot of fluids
such as water or fruit juice to keep yourself hydrated. Avoid taking any
medicine on your own to manage diarrhea. Consult your doctor immediately if the
symptoms worsen or persists during management with ORNOXIN TABLET.

Q: Can ORNOXIN TABLET cause tendon weakness?

A: ORNOXIN TABLET can increase the risk of tendon weakness or rupture. Stop
taking ORNOXIN TABLET and consult your doctor immediately if you experience
symptoms like tendon pain in joints, swelling, hearing or feeling a snap or pop
in a tendon area, bruising right after an injury in a tendon area, unable to
move the affected area or bear weight, etc.

Q: Is ORNOXIN TABLET safe to use in patients with heart problems?

A: ORNOXIN TABLET should be used with caution if you have heart disease such as
irregular heartbeat, poor functioning of the heart, heart attack, poor blood
supply to the heart. Your doctor will study your existing heart condition and
recommend relevant tests to outweigh the benefits to risks before suggesting you
ORNOXIN TABLET. If you experience any symptoms such as abnormal heartbeat,
sweating, severe loose stools and dizziness after taking ORNOXIN TABLET consult
your doctor immediately. Also, inform your doctor of the medications you are
taking to manage your heart or other conditions.

Q: Is ORNOXIN TABLET safe for use in diabetic patients?

A: ORNOXIN TABLET should be used with caution if you are having diabetes as this
medicine may alter your body’s sugar level. Your doctor may suggest monitoring
your body sugar level periodically. Consult your doctor for advice during
management with ORNOXIN TABLET.

Useful Diagnostic Tests

• Complete blood count
• Liver function test
• Kidney function test
• Bacterial Culture sensitivity test