NUSAM 200MG(L)

Introduction About NUSAM 200MG(L)

NUSAM 200MG(L) contains S-Adenosyl-L-Methionine which belongs to the group of
medicines called Amino acid derivatives. It is used to manage liver problems
such as intrahepatic cholestasis (ICP; block in bile flow), liver cirrhosis,
hepatitis and alcoholic liver disease in adults.

It can also be used to manage ICP of pregnancy and can reduce the fatigue caused
by chronic liver problems. It also helps to reduce joint pain (osteoarthritis),
fibromyalgia (severe muscle pain with memory and mood problems), anxiety,
depression and other mental illnesses.

Before taking NUSAM 200MG(L) inform your doctor if you have any kidney problems.
You must also inform your doctor if you have bipolar disorder or a previous
history of suicidal thoughts as a precaution.

Vitamins such as folic acid and vitamin B12 are essential to enhance the effects
of S-Adenosyl-L-Methionine in your body. Therefore, inform your doctor if you
have any vitamin deficiencies or anemia as a precaution. You doctor may advise
you to take B-vitamin supplements (folic acid and vitamin B12) along with this
medicine.

During management with NUSAM 200MG(L) your doctor will routinely monitor the
levels of ammonia, folic acid and vitamin B12 in your blood as a precaution and
adjust the dose accordingly.

Do not take NUSAM 200MG(L) without consulting your doctor if you are pregnant or
breastfeeding. The most common side effects of taking NUSAM 200MG(L) are nausea,
stomach pain and diarrhea. Consult your doctor if they trouble you.

Uses Of NUSAM 200MG(L)

It is used in adults to manage:

• intrahepatic cholestasis (ICP) in patients with or without liver disease
• intrahepatic cholestasis during pregnancy
• liver diseases (liver cirrhosis, hepatitis and alcoholic liver disease)
• fatigue caused due to chronic liver problems
• anxiety, depression and other mental illnesses
• osteoarthritis (joint pain)
• fibromyalgia (severe muscle pain causing memory and mood changes)

How NUSAM 200MG(L) Works

NUSAM 200MG(L) protects your liver against various toxins (free radicals) and
helps your liver to function normally. It improves the levels of glutathione (an
antioxidant) in the liver which helps in managing further liver cell damage.

It also increases the levels of certain chemical messengers (such as dopamine,
noradrenaline, adrenaline, serotonin, melatonin) in the brain that can stabilize
mood and mental health. It can also reduce the production of certain chemicals
in the body that causes pain and inflammation.

How to use NUSAM 200MG(L)

Take NUSAM 200MG(L) as advised by your physician. Swallow the medicine with a
glass of water. Do not cursh or chew the medicine. It is preferably taken before
meals.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of NUSAM 200MG(L)

Common

• Nausea
• Stomach pain
• Diarrhea
• Bloating
• Stomach discomfort

Rare

Stop taking NUSAM 200MG(L) and consult your doctor immediately if you experience
any of the following side effects:

• signs of serotonin syndrome (such as feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
• signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)
• worsening of depression

How To Manage Side Effects

Nausea or vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating
rich or spicy food. Contact your doctor if nausea worsens.

Diarrhoea:

Drink fluids, such as water or fruit juice in enough quantity to keep yourself
hydrated. Don’t take any medicine on your own for managing diarrhoea without
talking to your doctor. Contact your doctor if diarrhoea worsen.

Warning & Precautions

!### Pregnancy

NUSAM 200MG(L) is not recommended for use in pregnant women unless considered
necessary by the physician. Therefore, consult your doctor before taking it.

!### Breastfeeding

NUSAM 200MG(L) is not recommended for use in breastfeeding women unless
considered necessary by the physician. Therefore, consult your doctor before
taking it.

!### Driving and Using Machines

Do not drive or operate any heavy tools or machines if you experience dizziness
after taking NUSAM 200MG(L) as a precaution.

!### Kidney

NUSAM 200MG(L) should be used with caution in patients with kidney diseases.
Therefore, consult your doctor before taking it.

!### Allergy

Do not take NUSAM 200MG(L) if you are allergic to S-Adenosyl-L-Methionine.

Others

NUSAM 200MG(L) is not recommended for use if you:

• have bipolar disease (alternative episodes of happiness and sadness)

Before taking NUSAM 200MG(L), inform your doctor if you:

• have anemia (low RBC in blood)
• have vitamin B12 or folic acid deficiency
• have a previous history of suicidal thoughts

Use in pediatrics:

The safety and effectiveness of NUSAM 200MG(L) have not been established in
children and adolescents (aged below 18 years). Therefore, consult your doctor
for advice before taking it.

Use in geriatrics:

NUSAM 200MG(L) should be used with caution in elderly patients (aged 65 years or
above). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking NUSAM 200MG(L), inform your doctor if you are taking any of the
following medicines such as:

• other medicines used to manage depression (Ex. phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, moclobemide, fluoxetine, paroxetine, clomipramine, amitriptyline, imipramine etc.)
• levodopa (a medicine used to manage Parkinson’s disease)
• tryptophan (an amino acid used to induce sleep)

Overdosage:

If you or anyone else accidentally took more NUSAM 200MG(L), consult your doctor
immediately or visit the nearby hospital.

Synopsis

Drug	:	S-Adenosyl-L-Methionine
Pharmacological Category	:	Amino acid Derivatives
Therapeutic Indication	:	Liver disease, Depression, Osteoarthritis
Dosage Forms	:	Tablet, Capsule

More Information

• Keep NUSAM 200MG(L) out of sight and reach of children
• Store NUSAM 200MG(L) below 25°C

FAQs About NUSAM 200MG(L)

What is the use of NUSAM 200MG(L)?

NUSAM 200MG(L) is used to manage liver problems such as intrahepatic cholestasis
(ICP; block in bile flow), liver cirrhosis, hepatitis and alcoholic liver
disease in adults. It can also be used to manage ICP of pregnancy and can reduce
the fatigue caused by chronic liver problems. It also helps to reduce joint pain
(osteoarthritis), fibromyalgia (severe muscle pain with memory and mood
problems), anxiety, depression and other mental illnesses.

Can [GBNKEWORD] reduce liver damage?

Yes. NUSAM 200MG(L) protects your liver against various toxins (free radicals)
and helps your liver to function normally. It also improves the levels of
glutathione (an antioxidant) in the liver which helps in managing further liver
cell damage.

What is the best time to take NUSAM 200MG(L)?

Take NUSAM 200MG(L) approximately at the same time each day. You can take NUSAM
200MG(L) either in the morning or in the evening as per doctor’s instructions.
Taking it at the same time each day will have the best effect and it would also
help you remember your daily dose.

Can NUSAM 200MG(L) be used to reduce anxiety?

NUSAM 200MG(L) has been shown to reduce anxiety. It works by increasing the
levels of certain chemicals within the brain that controls mood and mental
health.

How does NUSAM 200MG(L) works?

NUSAM 200MG(L) protects your liver against various toxins (free radicals) and
helps your liver to function normally. It also increases the levels of certain
chemical messengers (such as dopamine, noradrenaline, adrenaline, serotonin,
melatonin) in the brain that can stabilize mood and mental health. It can also
reduce the production of certain chemicals in the body that causes pain and
inflammation.

Can NUSAM 200MG(L) be used in children?

The safety and effectiveness of NUSAM 200MG(L) have not been established in
children and adolescents (aged below 18 years). Therefore, consult your doctor
for advice before taking it.

What to do if I forget to take a dose of NUSAM 200MG(L)?

If you forget to take a dose of NUSAM 200MG(L), take it as soon as you remember.
However, if it is time to take the next dose, skip the missed dose and take the
next one at regular times. Do not take a double dose of NUSAM 200MG(L) to
compensate a missed dose, as it could lead to toxicity.

Will taking a higher dose of NUSAM 200MG(L) than the prescribed one be
beneficial?

No, taking a higher dose of NUSAM 200MG(L) will not be effective rather it can
lead to toxicity. Always take the dose prescribed by your doctor. If the
prescribed dose is not effective for you, consult your doctor for advice. Your
doctor might increase the dose or suggest an alternative therapy.

Can NUSAM 200MG(L) be taken daily?

Yes. NUSAM 200MG(L) can be taken daily as per your doctor’s instruction.
However, if you are doubtful, consult your doctor.

Can NUSAM 200MG(L) be used in pregnant women?

NUSAM 200MG(L) is not recommended for use in pregnant women unless considered
necessary by the physician. Therefore, consult your doctor before taking it.

How to take NUSAM 200MG(L)?

Take NUSAM 200MG(L) as advised by your physician. It is preferably taken before
meals. Swallow the medicine with a glass of water. Do not chew or crush the
medicine.

Can I stop taking NUSAM 200MG(L) once I started feeling better?

Do not stop taking NUSAM 200MG(L) without consulting your doctor as it may make
your symptoms re-appear

What are the side effects of NUSAM 200MG(L)?

The most common side effects of taking NUSAM 200MG(L) are nausea, stomach pain
and diarrhoea. Consult your doctor if they trouble you.

Is NUSAM 200MG(L) safe?

NUSAM 200MG(L) is safe at doses prescribed by the doctor. Do not alter the
dosage of NUSAM 200MG(L) without consulting your doctor.

Useful Diagnostic Tests

• Liver function test
• Bilirubin Direct
• Bilirubin indirect
• Bilirubin Total