NERVZONE M Capsule 10's

Introduction About NERVZONE M CAPSULE

NERVZONE M CAPSULE is used for the management of neuropathic pain. It is a
combination of Pregabalin and Methylcobalamin which belongs to the group of
medicines called Anticonvulsants and Vitamin-B complex respectively. It consists
of Methylcobalamin and Pregabalin where Methylcobalamin acts by rejuvenating the
damaged neurons by improving the production of myelin and pregabalin acts by
interfering with various pain signals travelling through the damaged nerves and
the brain, thus leading to a significant pain relief in various neuropathic pain
states.

Do not stop taking NERVZONE M CAPSULE without consulting your doctor as it could
precipitate withdrawal symptoms such as headache, insomnia, nausea, pain,
diarrhea, flu syndrome, anxiety, nervousness, depression, convulsion, excessive
sweating, dizziness and physical dependence. NERVZONE M CAPSULE has high
potential to cause addiction and therefore caution should be exercised among
patients who already has a history of substance abuse.

NERVZONE M CAPSULE is not recommended for use in pregnant or breastfeeding women
unless advised by the doctor and in male patients who plan to father a child.
The most common side effects are dizziness, sleepiness, headache, dry mouth,
mood changes, fluid retention and weight gain. Consult your doctor if any of the
side effects worsen.

Uses Of NERVZONE M CAPSULE

• Used to manage neuropathic pain

How NERVZONE M CAPSULE Works

NERVZONE M CAPSULE effectively alleviates the symptoms of various types of
neuropathic pain, where Methylcobalamin acts by rejuvenating the damaged neurons
by improving the production of myelin and Pregabalin acts by interfering with
various pain signals travelling through the damaged nerves and the brain, thus
leading to a significant pain relief in various neuropathic pain states.

How to use NERVZONE M CAPSULE

• Take NERVZONE M CAPSULE as advised by your physician
• Swallow NERVZONE M CAPSULE with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration depending upon your age, body weight and disease condition

Side Effects Of NERVZONE M CAPSULE

Common side effects of NERVZONE M CAPSULE:

• dizziness
• sleepiness
• headache
• common cold
• nausea, vomiting
• increased appetite
• constipation, diarrhea, flatulence, abdominal distension
• dry mouth
• feeling excited or pleasurable)
• impaired balance or coordination
• tremor (shaking)
• tingling and numbness in extremities)
• tiredness
• blurred vision
• spinning sensation
• muscle cramps
• pain in limbs, joints or back
• cervical spasm (a sudden, involuntary contraction of a muscle in the neck)
• joint swelling, muscle or neck pain

Stop taking NERVZONE M CAPSULE and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions (skin rash, itching, swelling of the face, lips, throat, neck and difficulty in breathing)
• symptoms of elevated creatine kinase (unexplained muscle pain, tenderness or weakness, accomp

Warning & Precautions

!### Pregnancy

Consult your doctorThere is no proper information on the use of NERVZONE M CAPSULE during pregnancy
and therefore should be used only if the benefit to the mother clearly outweighs
the potential risk to the fetus.

!### Breastfeeding

Monitoring requiredNERVZONE M CAPSULE is not recommended for use in breastfeeding women unless it
is considered clearly necessary.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness
or sleepiness after taking this medicine.

!### Alcohol

Consult your doctorAvoid consum
impairment of motor skills and sedating effects of alcohol.

!### Kidney

Use with CautionNERVZONE M CAPSULE should be taken with caution in patients with impaired kidney
function.

!### Liver

Use with CautionNERVZONE M CAPSULE should be taken with caution in patients with liver disease.

!### Allergy

ContraindicatedDo not take NERVZONE M CAPSULE if you are allergic to Pregabalin,
Methylcobalamin or any other ingredients of this medicine.

!### Heart Disease

Use with CautionNERVZONE M CAPSULE should be taken with caution in patients with heart disease
such as congestive heart failure.

!### Use In Pediatrics

ContraindicatedNERVZONE M CAPSULE is not recommended for use in children and adolescents (aged
below 18 years) due to lack of safety data.

!### Use In Geriatrics

Use with CautionNERVZONE M CAPSULE should be used with caution in elderly patients (aged 65
years and above), especially in patients with decreased renal function. Proper
dose adjustments and careful monitoring of kidney function are required in such
patients.

Others

NERVZONE M CAPSULE is not recommended for use if you:

• have Leber’s disease
• have problems in glucose metabolism

Before taking this medicine, inform your physician if you:

• have history of misuse or substance abuse
• have folate deficiency
• have diabetes
• have epilepsy
• have or at risk of encephalopathy

Interactions

A. Drug-Drug interactions:

Before taking the medicine, inform your doctor if you are taking any of the
following medicines:

• Anti-diabetics (Ex. metformin, pioglitazone, rosiglitazone)
• Anti-spasticity agents (Ex. dantrolene, baclofen)
• Opioid analgesics (Ex. morphine, pethidine)
• CNS depressants (Ex. lorazepam)
• Oral contrace
• Antibiotics (Ex. Chloramphenicol)
• Vitamins (Ex. folic acid, Vitamin C)
• Anti-lipidemic agents (Ex. cholestyramine or colestipol)
• Anti-gout agents (Ex. Colchicine)
• Antituberculosis agent (Ex. Para-amino salicylic acid)
• Electrolyte supplement (Ex. Potassium chloride)

Overdosage:

If you or anyone else accidentally takes too much of NERVZONE M CAPSULE, contact
your doctor immediately or go to a hospital straight away. Overdosage symptoms
such as sleepiness, confusion, agitation, restlessness or seizures.

Synopsis

Drug	:	Pregabalin, Methylcobalamin
Pharmacological Category	:	Anticonvulsants, Vitamin B complex
Therapeutic Indication	:	Neuropathic pain
Dosage Forms	:	Tablet, Capsule, Soft gels, Syrup

More Information

FAQs About NERVZONE M CAPSULE

Q: Can NERVZONE M CAPSULE affect fertility?

A: Fertility studies in men have shown that there were no effects on sperm
motility. However, NERVZONE M CAPSULE can be associated with an increased risk
of male-mediated teratogenicity (abnormalities in fetus). Men being managed with
this medicine who plan to father a child should be informed about the potential
risk of male-mediated teratogenicity. There are not enough clinical data on the
effects of this medicine on female fertility.

Q: Can NERVZONE M CAPSULE cause weight gain?

A: Yes. It may cause weight gain in some individuals mainly due to the formation
of peripheral edema (fluid retention). Inform your doctor if you have diabetes
prior to management with [as a precaution.

Q: Can NERVZONE M CAPSULE decrease libido?

A: Yes, NERVZONE M CAPSULE may cause decrease in sex drive (libido) in some
individuals, although not everybody gets them.

Q: Is NERVZONE M CAPSULE addictive?

A: Yes, NERVZONE M CAPSULE has high potential to create substance abuse or
dependence and therefore caution should be exercised among patients who already
has a history of substance abuse.

Q: Can I stop taking NERVZONE M CAPSULE once my pain is relieved?

A: No. Do not stop taking NERVZONE M CAPSULE without consulting your doctor as
it could precipitate withdrawal symptoms such as headache, lack of sleep,
nausea, pain, diarrhea, flu syndrome, anxiety, nervousness, depression,
convulsion, hyperhidrosis and dizziness and dependence. If your condition
improves, contact your doctor so that he might reduce the dose appropriately
before discontinuation of the therapy with the medicine.

Useful Diagnostic Tests

• Complete Blood Count (CBC) with ESR
• Liver Funtion Basic
• Kidney Function Test with Electrolytes (KFT / RFT)
• Advance Diabetes Care
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin