MPCACH 500 Injection 1's

Introduction About MPCACH 500 INJECTION

MPCACH 500 INJECTION is used to manage various adrenal gland problems, including
adrenal insufficiency, congenital adrenal hyperplasia, and nonsuppurative
thyroiditis. It is also effective in managing autoimmune and inflammatory
conditions affecting different parts of the body, such as rheumatoid arthritis,
ankylosing spondylitis, systemic lupus erythematosus, psoriasis, o
uveitis, asthma, and certain blood disorders like leukemia. Additionally, it
helps manage inflammatory bowel diseases like Crohn's disease and ulcerative
colitis, as well as tuberculous meningitis in the brain.

This medication is also prescribed for managing severe allergic reactions,
including drug-induced hypersensitivity, atopic dermatitis, allergic
conjunctivitis, and allergic rhinitis. It can prevent graft rejection after
organ transplantation and support kidney health by reducing protein loss in the
urine or increasing urine output in conditions like nephrotic syndrome.

It contains Methylprednisolone which belongs to the group of medicines called
Corticosteroids.

Before receiving MPCACH 500 INJECTION inform your doctor if you any viral
infections, or any liver, kidney or heart problems. You must also inform your
doctor if you have hypertension, diabetes, thyroid deficiency, glaucoma, skin
problem, gut inflammation, muscle problems, osteoporosis, any types of tumors or
cancer in the body, depression or any other forms of mental illness.

MPCACH 500 INJECTION is not recommended for use in patients with severe fungal
infections, brain swelling due to malaria, or brain injury or stroke. It should
be used in pregnant or breastfeeding women only if it is considered necessary by
the physician. Avoid drinking grapefruit juice or eating grapefruit while
receiving MPCACH 500 INJECTION as it may lead to unwanted side effects.

The most common side effects of receiving MPCACH 500 INJECTION are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

You must also inform your doctor if you experience severe depression with
suicidal thoughts or severe stomach pain with blood-stained stools or vomit
after receiving it.

Uses Of MPCACH 500 INJECTION

It is used to manage the following disease conditions:

• adrenal insufficiency and its associated conditions
• bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
• skin and collagen disorders (Ex. severe erythema multiforme)
• eye problems (Ex. o
• respiratory tract diseases (Ex. asthma, tuberculosis)
• blood cancer (leukemia), lymph cancer (lymphoma)
• problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
• brain problems (Ex. tuberculous meningitis)
• drug induced hypersensitivity reactions
• allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

• prevent graft rejection following organ transplantation
• reduce flare-ups of multiple sclerosis and other stressful conditions
• improve urine output or reduce protein loss in urine among patients having nephrotic syndrome

How MPCACH 500 INJECTION Works

MPCACH 500 INJECTION is a corticosteroid medicine with anti-inflammatory and
immune suppressant properties. It boosts your body with sufficient
corticosteroid levels (cortisol, aldosterone) during deficient conditions and
helps your body to function properly.

It also reduces the release of certain chemicals (prostaglandins) in the body
that causes pain, swelling and inflammation. It manages graft rejection by
suppressing the immune functions and protects your kidney from damage in
patients with kidney problems.

How to use MPCACH 500 INJECTION

MPCACH 500 INJECTION will be given to you only by a doctor or a nurse into the
muscle (intramuscularly) or into the vein (intravenously). Your doctor will
decide the correct dose and duration of therapy for you depending upon your age,
body weight and disease condition.

Side Effects Of MPCACH 500 INJECTION

Like all medications, this medicine may cause side effects, although they do not
occur in everyone.

Common Side Effects of MPCACH 500 INJECTION:

• high blood pressure (causing headache, or a general feeling of being unwell)
• swelling of body parts
• muscle cramps, weakness or wasting
• cataract, blurred vision
• slowed growth in children
• moon shaped face (Cushingoid facies)
• feeling sad, mood changes, m
• problems in sleeping
• difficulty in thinking, confusion, loss of memory, hallucinations
• fear or frightening thoughts
• acne, poor wound healing
• skin thinning

Contact your doctor immediately if you experience any of the following side
effects while undergoing therapy with MPCACH 500 INJECTION:

• signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
• signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
• increased infections causing fever or a general feeling of being unwell
• signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
• signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
• signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
• signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
• thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
• feeling depressed, suicidal thoughts
• blurred vision or other visual disturbances

Warning & Precautions

!### Pregnancy

Monitoring requiredMPCACH 500 INJECTION should be used in pregnant women only if it is considered
necessary by the physician. Therefore, inform your doctor before receiving
MPCACH 500 INJECTION if you are pregnant, think you may be pregnant or planning
to have a baby.

!### Breastfeeding

Monitoring requiredMPCACH 500 INJECTION should be used in breastfeeding women only if it is
considered necessary by the physician.

!### Driving and Using Machines

Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness
after receiving MPCACH 500 INJECTION.

!### Alcohol

Consult your doctorAvoid consum
you feel drowsier.

!### Kidney

Use with CautionMPCACH 500 INJECTION should be used with caution in patients with kidney
diseases.

!### Liver

Use with CautionMPCACH 500 INJECTION should be used with caution in patients with liver
diseases.

!### Allergy

ContraindicatedTalk to your doctor before receiving MPCACH 500 INJECTION if you are allergic to
Methylprednisolone.

!### Lungs

ContraindicatedMPCACH 500 INJECTION is not recommended for use in patients with fungal
infection of the lungs.

!### Heart Disease

Use with CautionMPCACH 500 INJECTION should be used with caution in patients with heart problems
(such as recent heart attack or heart failure).

!### Use In Pediatrics

Consult your doctorMPCACH 500 INJECTION should be used in infants, children and adolescents (aged
below 18 years) only if prescribed by the physician. Therefore, consult your
doctor for advice before receiving it.

!### Use In Geriatrics

Use with CautionMPCACH 500 INJECTION should be used with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before receiving it.

Others

MPCACH 500 INJECTION is not recommended for use if you:

• have a widespread fungal infection (including thrush)
• got vaccinated recently or scheduled for any upcoming vaccinations
• are receiving management for brain swelling caused due to malaria
• are suffering from brain injury or stroke

Before receiving MPCACH 500 INJECTION, inform your doctor if you:

• have or had been in contact with someone who has chickenpox, measles or shingles
• have worm infestation (Ex. thread worm infection)
• have or ever had severe depression or bipolar disorder
• have a family history of mental illness
• have diabetes or a family history of diabetes
• have fits
• have or have a family history of glaucoma
• have viral or fungal infections of the eyes
• have hypertension (high blood pressure)
• have underactive thyroid gland (hypothyroidism)
• have joint infection
• have scleroderma (an autoimmune disorder causing skin tightness, cold extremities, joint pain and heart burn)
• have Kaposi’s sarcoma (a type of skin cancer)
• have any muscle problems (Ex. myasthenia gravis)
• have osteoporosis (brittle bones)
• have pheochromocytoma (a rare tumor of the adrenal glands)
• have skin abscess
• have stomach ulcer or other serious stomach or intestinal problems
• have thrombophlebitis (clots in veins)
• have or had tuberculosis
• have Cushing’s disease
• have brain injury due to trauma
• have any unusual stress
• have inflammation of the pancreas
• have se
• are scheduled for any upcoming surgery (including dental surgery)

Interactions

A. Drug - Drug interactions:

Before receiving MPCACH 500 INJECTION, inform your doctor if you are taking any
of the following medicines such as:

• acetazolamide (a medicine used to manage glaucoma or edema)
• aminoglutethimide or cyclophosphamide (used for managing cancer)
• anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
• anti-cholinergic medicines used to manage myasthenia gravis (such as distigmine and neostigmine)
• antibacterials (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
• anti diabetics (Ex. metformin, glipizide)
• aprepitant or fosaprepitant (antiemitics)
• non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
• antiepile
• carbenoxolone and cimetidine (antiulcer agents)
• ciclosporin, tacrolimus (immunosuppressants)
• Cardiovascular agents (such as digoxin, diltiazem or mibefradil)
• oral contrace
• medicines used to manage HIV infection (such as ritonavir, indinavir, cobicistat)
• Antifungals (such as ketoconazole, amphotericin B, itraconazole)
• muscle relaxants (Ex. pancuronium or vecuronium)
• diuretics (used to manage edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
• medicines used to manage asthma (such as aminophylline, salmeterol, formoterol)
• rifampicin and rifabutin (Antituberculosis)
• live vaccines

B. Drug - Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while undergoing therapy
with MPCACH 500 INJECTION as it may lead to unwanted side effects.

Overdosage:

MPCACH 500 INJECTION will be administered to you only by a doctor or a nurse in
a hospital, and so it is unlikely to receive an overdose. However, consult your
doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Methylprednisolone
Pharmacological Category	:	Synthetic Glucocorticoids
Therapeutic Indication	:	Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Manage graft rejection, Proteinuria
Dosage Forms	:	Tablet, Injection, Cream, Lotion

More Information

Storage

• Keep MPCACH 500 INJECTION out of reach of children
• Store MPCACH 500 INJECTION at room temperature

FAQs About MPCACH 500 INJECTION

Q: What is MPCACH 500 INJECTION used for?

A: MPCACH 500 INJECTION is a corticosteroid medicine used to manage adrenal
insufficiency. It can also be used to manage drug induced hypersensitivity
reactions, allergic reactions and various inflammatory auto-immune disease
conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc.
It also helps in management of graft rejection following organ transplantation,
reduces flare-ups of multiple sclerosis and increases urine output among
patients with kidney problems.

Q: How to take MPCACH 500 INJECTION?

A: MPCACH 500 INJECTION is not meant for self-administration. It will be given
to you only by a doctor or a nurse into the muscle (intramuscularly) or into the
vein (intravenously).

Q: Is MPCACH 500 INJECTION a steroid?

A: Yes. MPCACH 500 INJECTION is synthetic corticosteroid used to manage problems
of adrenal gland and various allergic, hypersensitivity and inflammatory
autoimmune disease conditions.

Q: What are the most common side effects of MPCACH 500 INJECTION?

A: The most common side effects of receiving MPCACH 500 INJECTION are high blood
pressure, swelling of body parts, muscle cramps or weakness, skin thinning,
feeling sad or depressed and slowed growth in children. Consult your doctor if
any of these side effect worsens.

Q: Can MPCACH 500 INJECTION make you feel high?

A: Yes. MPCACH 500 INJECTION may make you feel high. Such symptoms may disappear
once the therapy has been stopped. However, consult your doctor if it bothers
you.

Q: How does MPCACH 500 INJECTION works?

A: MPCACH 500 INJECTION boosts your body with sufficient corticosteroid levels
and helps your body to function properly. It also reduces the release of certain
chemicals in the body that causes inflammation. It also manages graft rejection
by suppressing the immune functions and protects your kidney from damage in
patients with kidney problems.

Q: How long will it take for MPCACH 500 INJECTION to control my disease?

A: The time taken by MPCACH 500 INJECTION to control the disease may vary from
person-to-person depending upon the dose of methylprednisolone administered and
disease severity.

Q: Is MPCACH 500 INJECTION safe to use in diabetic patients?

A: MPCACH 500 INJECTION may alter the blood sugar levels in your body.
Therefore, it is necessary to inform your doctor if you have diabetes before
receiving MPCACH 500 INJECTION as a precaution.

Q: Who should not take MPCACH 500 INJECTION?

A: MPCACH 500 INJECTION is not recommended for use in patients with serious
fungal infections, brain swelling due to malaria or brain injury or stroke. It
is also not suitable for use in patients who got vaccinated recently.

Q: Can I receive MPCACH 500 INJECTION daily?

A: Your doctor will evaluate your health condition and suggests whether can you
receive MPCACH 500 INJECTION every day or not.

Q: Can MPCACH 500 INJECTION be used in children?

A: MPCACH 500 INJECTION should be used in children and adolescents (aged below
18 years) only if prescribed by the physician. Therefore, consult your doctor
for advice before receiving it.

Q: Will MPCACH 500 INJECTION alter the effects of birth control pills?

A: MPCACH 500 INJECTION may reduce the effects of birth control pills.
Therefore, try to avoid taking birth control pills along with MPCACH 500
INJECTION. Consult your doctor for advice.

Q: Can MPCACH 500 INJECTION be used in pregnant women?

A: MPCACH 500 INJECTION should be used in pregnant women only if it is
considered necessary by the physician. Therefore, inform your doctor before
receiving MPCACH 500 INJECTION if you are pregnant, think you may be pregnant or
planning to have a baby.

Useful Diagnostic Tests

• Absolute Eosinophil Count
• Anti-Nuclear Antibody
• Anti-ds-DNA Antibody
• Anti-ds-DNA Antibody-IFA
• Peripheral Smear Examination
• Total IgE