Metpure H Tablet 10'S

Introduction About METPURE H TABLET

METPURE H TABLET is a combination of Hydrochlorothiazide and S(-)Metoprololwhich
belongs to the group of medicines called Antihypertensive agents. It is used to
manage hypertension (high blood pressure). It can also be used to reduce the
risk of heart attack (myocardial infarction), stroke, chest pain (angina) and
uneven heartbeat (arrhythmia).

Before taking METPURE H TABLET inform your doctor if you have any liver or
kidney problems. You must also inform your doctor if you have diabetes, thyroid
problems, asthma, low blood pressure, poor blood circulation, psoriasis,
allergic reactions or gout as a precaution.

METPURE H TABLET is not recommended for use in patients with severe heart
problems apart from hypertension (such as uncontrollable heart failure or heart
block). Do not take this medicine without consulting your doctor if you are
pregnant or breastfeeding.

The most common side effects of taking this medicine are low blood pressure,
slow heart rate, cold hands and feet, racing heartbeat, headache, dizziness,
nausea, diarrhoea and constipation. Consult your doctor if any of these side
effect worsens.

Uses Of METPURE H TABLET

It is used to:

• Manage Hypertension (high blood pressure)
• Prevent heart attack, stroke, angina (chest pain) or arrhythmia (uneven heartbeat)

How METPURE H TABLET Works

METPURE H TABLET is an antihypertensive medicine. It contains two medicines
namely, S(-)Metoprolol and hydrochlorothiazide. S(-)Metoprolol works by blocking
the actions of certain chemical messengers (such as adrenaline) in the body that
increases heart rate and blood pressure.

Hydrochlorothiazide works by reducing the thickness of the blood by removing
excess fluids from the body in the form of urine. It also helps in improving
blood supply across all parts of the body. Collectively, these actions reduce
the strain on the heart and helps the heart to pump more blood with less
pressure.

How to use METPURE H TABLET

Take METPURE H TABLET as directed by your physician. Swallow the medicine with a
glass of water. Do not crush or chew the medicine. METPURE H TABLET can be taken
with or without food.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and health condition. Do not stop taking
this medicine without consulting your doctor.

Side Effects Of METPURE H TABLET

Common

• feeling faint or dizzy while standing up
• slow heart rate
• loss of balance, fainting
• cold hands and feet
• racing heartbeat
• headache, dizziness
• nausea, diarrhoea, constipation, stomach pain
• shortness of breath even with mild physical activity

Uncommon

• chest pain
• weight gain
• depression
• concentration problems, nightmares
• inability to sleep
• drowsiness
• tingling in the skin
• rashes
• increased sweating, fluid retention
• muscle cramps

Rare

• worsening of diabetes

• dry mouth, runny nose, hair loss

• nervousness, anxiety

• visual disturbances

• dry or irritated eyes

• impotence or other sexual dysfunctions

• bending of penis on erection (peyronie’s syndrome)

Stop taking METPURE H TABLET and contact your doctor immediately if you
experience any of the following side effects:

• severe allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)

How To Manage Side Effects

Nausea:

Take METPURE H TABLET with or just after a meal or a snack. Stick to simple
meals. Avoid eating rich or spicy food. Consult your doctor if your nausea
worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

Warning & Precautions

!### Pregnancy

METPURE H TABLET is not recommended for use in pregnant women. Therefore,
consult your doctor before taking it.

!### Breastfeeding

METPURE H TABLET is not recommended for use in breastfeeding women. Therefore,
consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if your ability is affected by METPURE H
TABLET.

!### Alcohol

Avoid consum
feel dizzier and drowsier.

!### Kidney

METPURE H TABLET should be used with caution in patients with kidney problems.
Therefore, consult your doctor before taking it.

!### Liver

METPURE H TABLET should be used with caution in patients with liver problems.
Therefore, consult your doctor before taking it.

!### Allergy

Do not take METPURE H TABLET if you are allergic to Hydrochlorothiazide,
S(-)Metoprolol or to any other beta-blockers (such as atenolol, propranolol).

!### Lungs

METPURE H TABLET is not recommended for use in patients with severe asthma or
chronic obstructive pulmonary disease. Therefore, consult your doctor for advice
before taking it.

!### Heart Disease

METPURE H TABLET is not recommended for use in patients with severe heart
problems (such as heart block, uncontrollable heart failure, sick sinus syndrome
or a very slow or uneven heartbeat). It should be used with caution in patients
with other heart problems (such as a recent heart attack or angina attack,
enlarged heart muscles or surgery in the heart within the last 4 months).
Therefore, consult your doctor before taking it.

Others

METPURE H TABLET is not recommended for use if you:

• are in shock caused due to poor blood circulation
• have poor blood circulation caused due to blockage in the blood vessels
• have a very low blood pressure
• have metabolic acidosis (too much acidity in blood)
• have unmanageed phaeochromocytoma (tumor present in adrenal glands)

Before taking METPURE H TABLET, inform your doctor if you:

• are prone to allergic reactions very often (such as even for insect bites)
• have problems in blood circulation around the body (especially in fingers, arms and feet)
• have diabetes
• have thyrotoxicosis (increased thyroid hormones in the body)
• are severely dehydrated
• have low sodium, potassium or magnesium levels in the blood
• are going to undergo an operation
• have gout
• have psoriasis (white scaly patches on the skin)

Use in Pediatrics:

METPURE H TABLET is not recommended for use in children and adolescents (aged
below 18 years). Therefore, consult your doctor for advice.

Use in Geriatrics:

METPURE H TABLET should be used with caution in the elderly patients. Therefore,
consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking METPURE H TABLET inform to your doctor, if you are taking any of
these medicines:

• lithium (a medicine used to manage mental illnesses)
• other medicines used to manage hypertension (such as clonidine, moxonidine, methyldopa, rilmenidine)
• other medicines used to manage heart problems (such as propafenone, verapamil, diltiazem and nifedipine)
• medicines used to manage uneven heartbeat (such as digoxin, disopyramide, quinidine or amiodarone)
• adrenaline (a medicine used to stimulate heart functions)
• medicines used for pain and inflammation (such as ibuprofen, indomethacin, sulindac, diclofenac)
• medicines used to manage diabetes (such as insulin, metformin, glimepiride, teneligli
• medicines that can depress the brain such as barbiturates (Ex. phenobarbital)
• narcotic drugs (used for pain relief) such as morphine, fentanyl, pethidine
• medicines used to reduce blood cholesterol levels (such as cholestyramine, colestipol)
• corticosteroids (used to manage inflammation) Ex. prednisolone
• corticotropin (a medicine used to correct hormone problems)
• noradrenaline (a medicine used to increase blood pressure)
• tubocurarine, dantrolene (medicines used to relax muscles)
• medicines used to manage depression (such as fluoxetine, paroxetine, bupropion)
• medicines used to manage mental illnesses (such as thioridazine)
• antihistamines (used to manage allergic reactions) such as diphenhydramine
• medicines used to manage malaria (such as hydroxychloroquine, mefloquine)
• terbinafine (a medicine used to manage fungal infection)
• cimetidine (a medicine used to manage stomach ulcers)
• phenylpropanolamine (a medicine used to reduce the swelling of the nasal mucosa)
• beta blockers used for glaucoma (such as timolol, pindolol, labetalol)
• ergotamine (a medicine used for migraine headache)
• medicines used to manage angina (such as nitroglycerin)
• anaesthetics (used to cause numbness or loss of sensation) such as lidocaine, sevoflurane, halothane
• rifampicin (used to manage tuberculosis)
• alpha blockers (used to manage high blood pressure and benign prostatic hyperplasia) such as prazosine, tamsulosin, terazosine, doxazosine
• antacids (medicines used to neutralise stomach acid) such as aluminium hydroxide, magaldrate

Overdosage:

If you or anyone else accidentally took more METPURE H TABLET, consult your
doctor immediately. Overdosage may cause low blood pressure, decreased
heartbeat, problems in breathing, vomiting, feeling faint and fits.

Synopsis

Drug	:	Hydrochlorothiazide, S(-)Metoprolol
Pharmacological Category	:	Thiazide diuretics, Beta blockers
Therapeutic Indication	:	Hypertension
Dosage Forms	:	Tablet

More Information

• Keep METPURE H TABLET out of reach of children
• Store METPURE H TABLET at room temperature

FAQs About METPURE H TABLET

Q: What are the uses of METPURE H TABLET?

A: METPURE H TABLET is used to manage hypertension and arrhythmia. It can also
be used to manage the risk of heart attack, stroke, angina and arrhythmia.

Q: What type of a medicine is METPURE H TABLET?

A: METPURE H TABLET is an antihypertensive medicine. It slows down your
heartbeat and reduces force of contraction of the heart. It also reduces the
thickness of the blood by removing excess fluids from the body in the form of
urine. Collectively, it reduces the strain on the heart and helps the heart to
pump blood more smoothly with less pressure.

Q: What happens when I stop taking METPURE H TABLET?

A: Do not stop taking METPURE H TABLET without consulting your doctor as your
blood pressure may raise once again. Make sure to take METPURE H TABLET for the
stipulated duration recommended by your doctor to achieve maximum results.

Q: What is the best time to take METPURE H TABLET?

A: METPURE H TABLET can be taken with or without meals. Your doctor will decide
the best time for you to take METPURE H TABLET based on your age, body weight
and disease condition.

Q: What to do if I forgot to take a dose of METPURE H TABLET?

A: If you forgot to take a dose of METPURE H TABLET, take it as soon as you
remember. However, if it is time for the next dose of METPURE H TABLET, skip the
missed dose and take the next one regularly. Do not take a double dose of
METPURE H TABLET to compensate the missed ones.

Q: What precautions should be followed while taking METPURE H TABLET?

A: Before taking METPURE H TABLET inform your doctor if you have any liver or
kidney problems. You must also inform your doctor if you have diabetes, thyroid
problems, asthma, low blood pressure, poor blood circulation, dehydration or
gout as a precaution. Consult your doctor before taking this medicine if you are
pregnant or breastfeeding. Regularly visit your doctor and take all the
necessary blood test recommended by your doctor without fail.

Q: Can I consume alcohol while taking METPURE H TABLET?

A: Avoid consum
you feel dizzier and drowsier.

Q: What happens if I accidentally take more METPURE H TABLET?

A: If you or anyone else accidentally took more METPURE H TABLET, consult your
doctor immediately. Overdosage may cause low blood pressure, decreased
heartbeat, problems in breathing, vomiting, feeling faint and fits.

Q: Can I take METPURE H TABLET daily?

A: Take METPURE H TABLET as advised by your physician. Your doctor will evaluate
your health condition and suggests whether can you take METPURE H TABLET every
day or not.

Q: Is METPURE H TABLET safe to use in diabetic patients?

A: METPURE H TABLET may alter the blood sugar levels in your body. Therefore, it
is necessary to inform your doctor if you have diabetes before taking METPURE H
TABLET as a precaution. Your doctor will closely monitor you blood sugar levels
to avoid the risk of side effects.

Q: What are the side effects of METPURE H TABLET?

A: The most common side effects of taking this medicine are low blood pressure,
slow heart rate, cold hands and feet, racing heartbeat, headache, dizziness,
nausea, diarrhoea and constipation. Consult your doctor if any of these side
effect worsens.

Q: Can I stop taking METPURE H TABLET once my symptoms subside?

A: No. Do not stop taking METPURE H TABLET without consulting your doctor. As
hypertension is a chronic condition, long term management may be necessary to
control its symptoms. Therefore, take METPURE H TABLET as advised by your doctor
for the stipulated duration. Premature discontinuation of therapy may increase
your blood pressure once again.

Q: CanMETPURE H TABLET be taken during pregnancy?

A: METPURE H TABLET is not recommended for use in pregnant women. Therefore,
consult your doctor before taking it.

Q: IsMETPURE H TABLET safe to use in kidney disease?

A: METPURE H TABLET should be used with caution in patients with kidney
problems. Your doctor will access your health condition and suggest a suitable
dose for you.

Q: Can the use of METPURE H TABLET affect the liver?

A: Yes. METPURE H TABLET may affect the way your liver work. It can elevate the
levels of certain liver enzymes in your body. Therefore, it should be used with
caution in patients with liver problems. Consult your doctor before taking it.

Q: Does METPURE H TABLET cause frequent urination?

A: Yes. METPURE H TABLET may cause frequent urination. It is because METPURE H
TABLET contains a medicine called hydrochlorothiazide which is a diuretic (water
pill). It excretes the excess water from the body in the form of urine.
Therefore, it is advised to take METPURE H TABLET at least 5 hours before
bedtime to avoid the urge at night to urinate.

Q: Can I take potassium supplements along with METPURE H TABLET?

A: Yes. Potassium supplements can be taken along with METPURE H TABLET. However,
consult your doctor before taking it.

Q: Can METPURE H TABLET cause photosensitivity reactions?

A: METPURE H TABLET very rarely causes skin sensitivity towards light
(photosensitivity). To manage this, minimize sun exposure or exposure towards
any forms of light sources. Always apply a sunscreen and wear protective
clothing while going out. Consult your doctor if this side effect troubles you.

Useful Diagnostic Tests

• Kidney Function Test