MANTEDANIB 150 Capsule 10's

Introduction About MANTED

MANTED
medicines called Kinase inhibitors. It is used to manage idiopathic pulmonary
fibrosis (IPF), chronic fibrosing interstitial lung diseases (ILDs) with a
progressive phenotype, slowing the rate of decline in pulmonary function in
patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
It is used in combination with docetaxel in adult patients for the management of
locally advanced metastatic or recurrent non-small cell lung cancer (NSCLC) of
adenocarcinoma tumor histology after first line chemotherapy.

Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disorder in which the
lungs become scarred and breathing becomes increasingly difficult. Symptoms
include shortness of breath, persistent dry cough, tiredness, loss of appetite,
weight loss, rounded and swollen fingertips (clubbed fingers).

Before taking MANTED
or bleeding problems, history of blood clots or had a recent surgery in stomach.
MANTED
advised by your doctor and it is not recommended for use in breastfeeding women
as it may pass through breast milk. Before starting management with MANTED
150 CAPSULE, your doctor may want you to take several blood tests to understand
your existing condition.

MANTED
years and above). The most common side effects of taking MANTED
are diarrhoea, nausea, vomiting, stomach pain, loss of appetite, headache,
weight loss and high blood pressure. Consult your doctor if any of the symptom
worsens.

Uses Of MANTED

• Manage idiopathic pulmonary fibrosis (IPF)
• Manage chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype
• To slow the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)

How MANTED

MANTED
blocking the enzymes in cells of the lungs called tyrosine kinases. Blocking
these enzymes helps to decrease fibrous tissue formation in the lungs, thereby
stops the symptoms of lung disease getting worse.

How to use MANTED

Take MANTED
with a glass of water. Do not crush, chew, or open the medicine. Your doctor
will decide the correct dose and duration for you based upon your age, body
weight and disease condition. Do not stop taking MANTED
your doctor advises you to stop.

Side Effects Of MANTED

Common

• diarrhoea
• nausea, vomiting
• stomach pain
• liver problems
• decreased appetite
• headache
• weight loss
• high blood pressure

Rare

Stop taking MANTED
experience any of the following side effects:

• severe liver problems symptoms such as yellowing of your skin or white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired, or loss of appetite
• severe diarrhoea, nausea and vomiting
• signs of heart attack such as chest pain or pressure, pain in arms, back, neck or jaw, or shortness of breath
• signs of stroke such as numbness or weakness on one side of your body, trouble talking, headache or dizziness
• signs of bleeding problem such as unusual bleeding, bruising, or wounds that do not heal
• signs of tear in stomach or intestinal wall (perforation) such as pain or swelling in stomach area
• signs of increased protein in urine (proteinuria) such as foamy urine, swelling of the hands, arms, legs, or feet or sudden weight gain

How To Manage Side Effects

!### Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhea and consult your doctor if
the symptom gets worse.

Headache

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress
free. Do not strain your eyes by watching screen for long time. Apply pain
relieving balm on your forehead if necessary. Consult your doctor if the symptom
gets worse.

!### Loss Of Appetite

Eat when you are hungry. Eat smaller meals more often than usual. Snack only
when you're hungry. Eat a nutritious snack which is rich in calories and
protein, such as dried fruit and nuts. Consult your doctor if the symptom does
not improve.

!### Nausea And Vomiting

Try to take MANTED
to simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if
the symptom gets worse.

!### Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more
frequently. Keep a heat pad on your stomach. If the stomach pain does not
improve, consult your doctor.

Warning & Precautions

!### Pregnancy

Monitoring requiredMANTED
considered clearly necessary. Consult your doctor before taking it.

!### Breastfeeding

ContraindicatedMANTED
may pass through breast milk. Consult your doctor before taking it.

!### Liver

Use with CautionMANTED
problems. Consult your doctor before taking it.

!### Allergy

ContraindicatedDo not take MANTED
the other ingredients of this medicine.

!### Heart Disease

Use with CautionMANTED
problems. Consult your doctor before taking it.

!### Use In Pediatrics

Consult your doctorThere is no proper information regarding the use of this medicine in children.
Consult child’s doctor for advice

!### Use In Geriatrics

Use with CautionMANTED
years and above). Consult your doctor before taking MANTED

Others

Before taking MANTED

• have history of blood clots
• have bleeding problem or a family history of bleeding problem
• had recent surgery in stomach (abdominal) area
• are a smoker

Interactions

A. Drug - Drug interactions:

Before taking MANTED
the following medicines:

• st. john’s wort (used to manage depression)
• laxatives such as bisacodyl, stool softeners such as lactulose (used to manage constipation)
• other medicines or dietary supplements (used to manage diarrhoea)
• blood thinners such as warfarin (used to manage or manage blood clots)
• aspirin (used to manage fever and pain)

Overdosage:

If you or anyone else accidentally take too much of MANTED
consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ninted
Pharmacological Category	:	Tyrosine Kinase Inhibitor
Therapeutic Indication	:	Idiopathic pulmonary fibrosis (IPF), Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, slows the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)
Dosage Forms	:	Capsule

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More Information

• Keep MANTED
• Store at room temperature

FAQs About MANTED

Q: Can I take MANTED

A: MANTED
clearly advised by your doctor. Consult your doctor before taking MANTED
CAPSULE if you are pregnant or planning to get pregnant.

Q: What to do If I forget to take a dose of MANTED

A: You should take MANTED
is time for your next dose skip the missed dose and follow your regular dose
schedule. Do not double the dose to match up your missed dose.

Q: Can I stop taking MANTED

A: Do not stop taking MANTED
stop. Remember that it works to slow the decline in lung function only for as
long as you keep taking it. If you stop taking MANTED
it worsens the lung function and increases the risk of life-threatening
complications.

Q: What are the common side effects of MANTED

A: The common side effects of taking MANTED
nausea, vomiting, stomach pain, loss of appetite, headache, weight loss, altered
liver enzymes and high blood pressure. Consult your doctor if any of the side
effect worsens.

Q: IsMANTED

A: MANTED
problems. Your doctor may monitor your liver function before and during
management with MANTED
unusual effects. Consult your doctor before taking MANTED

Useful Diagnostic Tests

• Liver function tests
• Pulmonary function tests