Lupibose 62.5mg Tablet 10'S

Introduction About LUPIBOSE 62.5MG TABLET

LUPIBOSE 62.5MG TABLET contains Bosentan which belongs to the group of medicines
called Endothelin receptor antagonists. LUPIBOSE 62.5MG TABLET is used to manage
pulmonary arterial hypertension in affected individuals which is a disease that
occurs due to high blood pressure in blood vessels that carry blood from heart
to the lungs.

LUPIBOSE 62.5MG TABLET is also used in adults to reduce digital ulcers (sores on
the fingers and toes) that occurs due to scleroderma which is a chronic disease
that cause skin to become thick and hard.

LUPIBOSE 62.5MG TABLET is not recommended for use in patients allergic to
Bosentan. It is also not recommended for use in patients suffering from liver
problems.

Before taking LUPIBOSE 62.5MG TABLET, inform your doctor if you are planning to
father a child, and/or have kidney problems (such as impaired renal function).

LUPIBOSE 62.5MG TABLET is generally not recommended for use during pregnancy and
in women planning for pregnancy since the medicine may cause harm to the unborn
child. It is also not recommended for use in breastfeeding women since it is not
known whether the medicine may pass through breastmilk.

LUPIBOSE 62.5MG TABLET is recommended for use in children and adolescents (aged
1 year and above) to manage only pulmonary hypertension and is not indicated for
use to manage systemic sclerosis and digital ulcer disease in affected children.
The medicine is advised to be used with caution in elderly patients (aged 65
years/above) after consulting the doctor.

The most common side effects of taking LUPIBOSE 62.5MG TABLET are headache,
oedema (swelling of legs & ankles), flushing/redness of skin, diarrhoea, low
blood pressure, and/or nasal congestion. Consult your doctor if any of these
symptoms worsen.

Uses Of LUPIBOSE 62.5MG TABLET

• Manage pulmonary artery hypertension
• Manage digital ulcers (that occurs due to scleroderma) in affected individuals

How LUPIBOSE 62.5MG TABLET Works

LUPIBOSE 62.5MG TABLET works by blocking the action of endothelin-1 hormone
(chemical that cause vasoconstriction) which leads to relaxation and widening of
blood vessel wall resulting in reduced pressure on the blood vessel wall and
managing pulmonary hypertension in affected individuals.

How to use LUPIBOSE 62.5MG TABLET

Take LUPIBOSE 62.5MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Side Effects Of LUPIBOSE 62.5MG TABLET

Common

• headache
• oedema (swelling of legs & ankles)
• flushed appearance/redness of skin
• signs of hypersensitivity reactions (immune mediated allergic reaction) such as skin inflammation, itching, and/or rashes
• gastroesophageal reflux disease (acid reflux)
• diarrhoea
• syncope (fainting)
• palpitations (fast/irregular heartbeats)
• low blood pressure
• nasal congestion

Rare

• signs of anaphylactic reaction (life threatening allergic reaction) such as skin rash, nausea, difficulty in breathing, and/or shock
• cirrhosis/scarring of the liver
• liver failure.

Stop taking LUPIBOSE 62.5MG TABLET and consult your doctor immediately if you
experience any of the following side effects:

• signs of abnormal/impaired liver function such as nausea, fever, pain in the stomach, jaundice (yellowing of the skin/whites of eyes), dark-coloured urine, itching, lethargy/fatigue, and/or flu-like symptoms such as joint & muscle pain with fever

How To Manage Side Effects

Headache:

If LUPIBOSE 62.5MG TABLET causes headache, then take rest and drink plenty of
fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a
painkiller. Headaches should usually go away after the first week of taking
LUPIBOSE 62.5MG TABLET. If it lasts more than a week or becomes severe, then
consult your doctor.

Diarrhea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on
your own to manage diarrhea. Consult your doctor if the symptom worsens.

Warning & Precautions

!### Pregnancy

LUPIBOSE 62.5MG TABLET is generally not recommended for use during pregnancy and
in women planning for pregnancy since the medicine may cause harm to the unborn
child. Women of child-bearing potential should use effective contrace
measures to manage accidental pregnancy while in management with LUPIBOSE 62.5MG
TABLET. Consult your doctor before taking the medicine.

!### Breastfeeding

LUPIBOSE 62.5MG TABLET is not recommended for use in breastfeeding women since
it is not known whether the medicine may pass through breastmilk. Consult your
doctor before taking the medicine.

!### Driving and Using Machines

Do not drive/operate any machines if you feel dizzy or experience blurred vision
after taking LUPIBOSE 62.5MG TABLET.

!### Kidney

LUPIBOSE 62.5MG TABLET should be used with caution in patients with kidney
problems such as impaired renal function. Consult your doctor before taking the
medicine.

!### Liver

LUPIBOSE 62.5MG TABLET is not recommended for use in patients with liver
problems. Consult your doctor before taking the medicine.

!### Allergy

Do not take LUPIBOSE 62.5MG TABLET if you are allergic to Bosentan, and/or any
other ingredients of the medicine.

Others

Before taking LUPIBOSE 62.5MG TABLET, inform your doctor if you:

• are planning to father a child (since this medicine may lower the sperm count).

Use in Paediatrics:

LUPIBOSE 62.5MG TABLET is recommended for use in children and adolescents (aged
1 year and above) to manage only pulmonary hypertension. It is not recommended
for use to manage systemic sclerosis and ongoing digital ulcer disease in
affected children. Consult your doctor before administering the medicine to the
child.

Use in Geriatrics:

LUPIBOSE 62.5MG TABLET should be used with caution in elderly patients (aged 65
years and above). Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug interactions:

Before taking LUPIBOSE 62.5MG TABLET, inform your doctor if you are taking any
of the following medicine:

• ciclosporin A (used after transplants and to manage psoriasis)
• sirolimus, tacrolimus (medicines used after transplants to manage organ rejection)
• glibenclamide (used to manage diabetes)
• rifampicin (use to manage tuberculosis)
• fluconazole, ketoconazole (medicines used to manage fungal infections)
• nevirapine (used to manage HIV infection)
• warfarin (used to manage blood clots)
• other medicine used to manage pulmonary hypertension (Ex. sildenafil, tadalafil)
• simvastatin (used to manage hypercholesterolaemia)
• hormonal contrace

Overdosage:

If you or anyone else accidentally take too much of LUPIBOSE 62.5MG TABLET,
consult your doctor immediately or visit the nearby hospital to manage overdose
symptoms.

Synopsis

Drug	:	Bosentan
Pharmacological Category	:	Endothelin receptor antagonists
Therapeutic Indication	:	Pulmonary artery hypertension, Digital ulcers (due to scleroderma)
Dosage Forms	:	Tablet

More Information

• Keep LUPIBOSE 62.5MG TABLET out of reach of children
• Do not store LUPIBOSE 62.5MG TABLET above 30 °C

FAQs About LUPIBOSE 62.5MG TABLET

What is LUPIBOSE 62.5MG TABLET used for?

LUPIBOSE 62.5MG TABLET is used to manage pulmonary arterial hypertension in
affected individuals which is a disease that occurs due to high blood pressure
in blood vessels that carry blood from heart to the lungs. It is also used in
adults to reduce digital ulcers (sores on the fingers and toes) that occurs due
to scleroderma which is a chronic disease that cause skin to become thick and
hard in affected individuals.

What are the side effects of taking LUPIBOSE 62.5MG TABLET?

The most common side effects of taking LUPIBOSE 62.5MG TABLET are headache,
oedema (swelling of legs & ankles), flushing/redness of skin, diarrhoea, low
blood pressure, and/or nasal congestion. Contact your doctor if any of these
symptoms worsen.

How LUPIBOSE 62.5MG TABLET works?

LUPIBOSE 62.5MG TABLET works by blocking the action of endothelin-1 hormone
(chemical that cause vasoconstriction) which leads to relaxation and widening of
blood vessel wall resulting in reduced pressure on the blood vessel wall and
managing pulmonary hypertension in affected individuals.

How LUPIBOSE 62.5MG TABLET should be taken?

Take LUPIBOSE 62.5MG TABLET as advised by your physician. Swallow the medicine
with a glass of water. Do not crush or chew the medicine. Your doctor will
decide the correct dose and duration for you depending upon your age, body
weight and disease condition.

Can LUPIBOSE 62.5MG TABLET be used in pregnant women?No, LUPIBOSE 62.5MG TABLET is generally not recommended for use during
pregnancy and in women planning for pregnancy since the medicine may cause harm
to the unborn child. Women of child-bearing potential should use effective
contrace
LUPIBOSE 62.5MG TABLET. Consult your doctor before taking the medicine.

Useful Diagnostic Tests

• Echocardiogram
• Right heart catheterization