Lamino Plus 10% Infusion 500ml

INTRODUCTION ABOUT LAMINO PLUS 10% INFUSION

LAMINO PLUS 10% INFUSION contains Amino acid which are naturally occurring
physiological compounds. It is used for management of protein depletion in
patients requiring parenteral nutrition when oral or enteral nutrition is not
possible, insufficient, or not recommended. LAMINO PLUS 10% INFUSION can be used
to manage negative nitrogen balance in patients.

LAMINO PLUS 10% INFUSION can also be used to manage hepatic encephalopathy in
patients with liver scarring or inflammation.

Your doctor might monitor your fluid an electrolyte status and various other
functions throughout your management.

LAMINO PLUS 10% INFUSION is not recommended for use in patients with amino acid
metabolism problems since birth, pulmonary edema, or excess acid in blood due to
low cardiac output. Before receiving LAMINO PLUS 10% INFUSION, inform your
doctor if you have diabetes, kidney, heart, or liver disease.

LAMINO PLUS 10% INFUSION should be used in pregnant and breastfeeding women only
if considered clearly necessary. LAMINO PLUS 10% INFUSION is not recommended for
use in children and should be used with caution in elderly patients, therefore
consult your doctor before receiving it.

The most common side effects of receiving LAMINO PLUS 10% INFUSION are
generalized flushing, fever, nausea, and local injection site reactions.
Contact your doctor if any of the symptoms worsen.

USES OF LAMINO PLUS 10% INFUSION

Prevents and manages,

• protein depletion in patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or not recommended

Manages,

• manage negative nitrogen balance
• manage hepatic encephalopathy in patients with liver scarring or inflammation

HOW LAMINO PLUS 10% INFUSION WORKS

LAMINO PLUS 10% INFUSION acts as a nutrition supplement by providing the
structural units that make up proteins and other biomolecules or are oxidized to
urea and carbon dioxide as an energy source.

DIRECTIONS FOR USE

LAMINO PLUS 10% INFUSION will be given to you only by a doctor or a nurse into a
vein as an intravenous infusion. Your doctor will decide the correct dose and
duration for you according to your age, body weight and disease condition.

SIDE EFFECTS OF LAMINO PLUS 10% INFUSION

COMMON

• generalized flushing
• fever
• nausea
• local injection site reactions

RARE

Stop receiving LAMINO PLUS 10% INFUSION and contact your doctor immediately if
you experience any of the following side effects:

• signs of pulmonary distress
• hypersensitivity reactions (low or high blood pressure, bluish discoloration of extremities, fast heartbeat, breathlessness, vomiting, nausea, hives, rash, itching, redness, excessive sweating, fever, chills)
• risk of infections and sepsis
• refeeding syndrome (shift in intracellular potassium, phosphorus, and magnesium levels)
• high blood sugar levels
• venous thrombophlebitis (pain, redness, tenderness, palpable veins)
• hepatobiliary disorders and Parenteral Nutrition Associated Liver Disease as seen in liver test abnormalities
• aluminum toxicity
• severely raised electrolyte levels, fluid overload

HOW TO MANAGE SIDE EFFECTS

Nausea:

Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy
foods. If nausea does not improve, contact your doctor.

WARNING & PRECAUTIONS

!### PREGNANCY

LAMINO PLUS 10% INFUSION should be used in pregnant women only if considered
clearly necessary. Consult your doctor before receiving it.

!### BREASTFEEDING

LAMINO PLUS 10% INFUSION should be used in breastfeeding women only if
considered clearly necessary. Consult your doctor before receiving it.

!### KIDNEY

LAMINO PLUS 10% INFUSION is not recommended for use in patients who are unable
to produce urine. LAMINO PLUS 10% INFUSION should be used with caution in
patients with history of renal disease or renal impairment. Consult your doctor
before receiving it.

!### LIVER

LAMINO PLUS 10% INFUSION is not recommended for use in patients with liver
diseases such as hepatic coma. LAMINO PLUS 10% INFUSION should be taken with
caution in patients with severe liver disease. Consult your doctor before
receiving it.

!### ALLERGY

Do not receive LAMINO PLUS 10% INFUSION if you are allergic to Amino acid or any
of the other ingredients of this medicine.

!### LUNGS

LAMINO PLUS 10% INFUSION is not recommended for use in patients with lung
diseases such as pulmonary edema. LAMINO PLUS 10% INFUSION should be used with
caution in patients with lung disease. Consult your doctor before receiving it.

!### HEART DISEASE

LAMINO PLUS 10% INFUSION should be used with caution in patients with cardiac
insufficiency or severe congestive heart failure. Consult your doctor before
receiving it.

OTHERS

LAMINO PLUS 10% INFUSION is not recommended for use if you have:

• amino acid metabolism problems since birth, due to risk of severe metabolic or neurologic complications
• acidosis (acid build-up)
• metabolic disorders with impaired nitrogen utilization
• azotemia (build-up of nitrogenous products in blood)

Before receiving LAMINO PLUS 10% INFUSION, inform your doctor if you have:

• conditions involving edema with sodium retention
• high blood potassium levels or potassium retention
• diabetes or are pre-diabetic

Use in pediatrics:

LAMINO PLUS 10% INFUSION is not recommended for use in children as safety and
efficacy of the medicine has not been studies in them. Consult your doctor
before receiving it.

Use in geriatrics:

LAMINO PLUS 10% INFUSION should be used with caution in elderly patients (aged
above 65 years). Consult your doctor before receiving it.

INTERACTIONS

A. Drug - Drug interactions:

Before receiving LAMINO PLUS 10% INFUSION, inform your doctor if you are taking
any of the following medicine:

• tetracycline (used to manage bacterial infections)

Overdosage:

LAMINO PLUS 10% INFUSION will be administered to you only by a doctor or a nurse
in a hospital, and so you are unlikely to receive an overdose. However, consult
your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug	:	Amino acid
Pharmacological Category	:	Naturally occurring physiological compounds
Therapeutic Indication	:	Protein depletion
Dosage Forms	:	Injection, Infusion

MORE INFORMATION

• Keep LAMINO PLUS 10% INFUSION out of reach of children
• Store LAMINO PLUS 10% INFUSION between 20-25°C

FAQs ABOUT LAMINO PLUS 10% INFUSION

Can LAMINO PLUS 10% INFUSION be taken in pregnancy?

LAMINO PLUS 10% INFUSION should be used in pregnant women only if considered
clearly necessary. If you are pregnant, think you may be pregnant or are
planning to get pregnant, consult your doctor before receiving this medicine.
Inform your doctor immediately if you become pregnant during management with
LAMINO PLUS 10% INFUSION.

Does LAMINO PLUS 10% INFUSION help lose weight?

LAMINO PLUS 10% INFUSION may help you lose weight, depending on whether you are
deficient or not. It is a simple and effective solution and offers great
benefits in achieving weight loss if you are deficient in a key amino acid
required for the metabolic process. It can give your body the nutrition it needs
so that you feel your best and can burn more calories. Consult your doctor
before receiving it.

Can LAMINO PLUS 10% INFUSION be stopped by my own?

Continue receiving LAMINO PLUS 10% INFUSION until your doctor tells you to stop,
unless you experience any unwanted effects, worsening of your condition or any
new symptoms. In such case, contact your doctor right away.

Can LAMINO PLUS 10% INFUSION be used in diabetic patients?

Administration of LAMINO PLUS 10% INFUSION in diabetic patients or patients with
impaired glucose tolerance may further increase blood sugar levels. Frequent
blood-sugar level measurements should be performed on diabetic patients
receiving this medicine.

What precautions do I need to follow while taking LAMINO PLUS 10% INFUSION?

Patients receiving LAMINO PLUS 10% INFUSION must inform their doctor about their
pre-existing conditions like kidney, liver, or heart problems, diabetes, or
amino acid metabolism problems since birth. Patients should also inform if they
are pregnant, breast-feeding, or having any allergies. Consult your doctor if
you experience anything different.

Can LAMINO PLUS 10% INFUSION cause nausea?

Nausea is a common side effect of LAMINO PLUS 10% INFUSION. If you feel
nauseous, take regular sips of a cold drink, or have ginger or peppermint tea.
Stick to simple meals and avoid eating oily or spicy foods. If nausea does not
improve, contact your doctor.

Can I take other medicines with LAMINO PLUS 10% INFUSION?

Before receiving LAMINO PLUS 10% INFUSION, inform your doctor if you are taking,
have taken, or might take any other medicine, including prescri
non-prescri
and cause serious side effects.

REFERENCES

1. Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry
   Jameson, Joseph Loscalzo. Care of the Hospitalized Patient. Harrison’s Manual of
   Medicine. 18th edition. Page- 50.

2. Liebau, F., Sundström, M., van Loon, L.J. et al. Short-term amino acid
   infusion improves protein balance in critically ill patients. Critical Care.
   BMC. December 2015. [Accessed on 16th July
   2022]

3. Shi Y, Song H, Liu J, Lin J, Fang L. Comprehensive Evaluation of Clinical
   Application of Balanced Compound Amino Acid Injection. NIH National Library of
   Medicine, National Centre for biotechnology information. PubMed Central. June

4. [Accessed on 16th July 2022].

5. Baxter Healthcare Corporation. Amino acid. [Revised in October 2020]
   [Accessed on 16th July 2022]

6. Hospira Healthcare Corporation. Amino acid. [Revised in April 2012] [Accessed
   on 16th July 2022]

7. La Renon Healthcare Pvt. Ltd. Amino acid. [Accessed on 16th July
   2022]

7 Innovative Pharmaceuticals. Amino acid. [Accessed on 16th July
2022]

USEFUL DIAGNOSTIC TESTS

• Total protein test