Ikgdar 500mg Injection 50ml

Introduction About IKGDAR 500MG INJECTION

IKGDAR 500MG INJECTION contains Rituximab which belongs to the group of
medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia)
and lymph cancer (lymphoma). It can also be used to manage various auto-immune
disease conditions such as rheumatoid arthritis, granulomatosis with
polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and
pemphigus vulgaris (severe skin blistering and peeling especially on the mouth,
nose, throat, eyes and genitals).

It is mostly used in combination with other cytotoxic anticancer agents to
achieve better results. It is suitable for use both in adults and in children
(aged 6 months or older). IKGDAR 500MG INJECTION will be administered to you
only by an oncologist or a trained professional into your vein (as intravenous
infusion).

Before receiving IKGDAR 500MG INJECTION inform your doctor if you have any heart
problems (such as chest pain, heart attack, heart failure or abnormal
heartbeat). You must also inform your doctor if you currently have or previously
had hepatitis B infection or any other mild infections (including minor cough
and cold) as a precaution.

IKGDAR 500MG INJECTION is not recommended for use in pregnant or breastfeeding
women. Both men and women receiving IKGDAR 500MG INJECTION must use a suitable
contrace
500MG INJECTION.

The most common side effects of receiving this medicine are fever, chills, skin
rashes with itching, shortness of breath and low blood pressure. Consult your
doctor if any of these side effect worsens.

Uses Of IKGDAR 500MG INJECTION

It is used to manage:

• Blood cancer (Chronic lymphocytic leukaemia)
• Lymph cancer (Non-Hodgkin’s Lymphoma)
• Rheumatoid arthritis (joint pain and inflammation)
• Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels)
• Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals)

How IKGDAR 500MG INJECTION Works

IKGDAR 500MG INJECTION is a monoclonal antibody. It destroys the immune cells
(B-cells) that triggers cancer formation. It also reduces the production of
certain chemicals within the body (such as rheumatoid factor, T-cells,
cytokines) that causes inflammation, pain and swelling which helps in managing
various autoimmune diseases.

How to use IKGDAR 500MG INJECTION

IKGDAR 500MG INJECTION will be given to you only by a doctor or a nurse into the
vein (intravenously).

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Side Effects Of IKGDAR 500MG INJECTION

Common

• increased infections (bacterial, viral or fungal)
• low RBC, WBC and platelet counts in blood
• nausea, vomiting, diarrhea, stomach pain, constipation, indigestion
• mouth ulcers
• hair loss
• fever, chills, pneumonia, shingles, cold, sinusitis
• thrush, urinary tract infection
• headache, dizziness, tiredness, weakness
• hepatitis B infection
• high blood sugar and cholesterol levels
• weight loss, lack of appetite
• numbness, tingling, pricking, burning sensation on the skin
• restlessness, problems in falling asleep, anxiety, depression
• flushing (skin redness)
• eye inflammation or watery eyes
• ringing sound in the ears, ear pain
• uneven or fast heart rate, high or low blood pressure
• shortness of breath, runny nose, nasal itching and repeated sneezing
• increased sweating, night sweats
• muscle pain, joint pain, back pain, neck pain
• pain while passing urine
• fungal foot infection (athlete’s foot)
• tremors (shakiness)
• swelling of the hands or ankles

Uncommon

• blood clotting problems
• changes in taste
• slow heart rate
• chest tightness and lung problems

Rare

Contact your doctor immediately if you experience any of the following side
effects:

• fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain
• fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell
• signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems)
• signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)

How To Manage Side Effects

!### Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and
drink plenty of water. Try doing exercise regularly (going for a daily walk or
run). If this does not help, inform your doctor for receiving alternate
managements for constipation.

!### Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid
taking any medicine on your own to manage diarrhoea and consult your doctor if
the symptom gets worse.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Consult your doctor if your
dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Consult your doctor if your headache worsens.

!### Mouth Ulcers

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on
the affected areas of the mouth if required. Consult your doctor if the symptom
did not improve.

!### Nausea And Vomiting

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea
worsens, consult your doctor for advice.

!### Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

!### Pregnancy

ContraindicatedIKGDAR 500MG INJECTION is generally not recommended for use in pregnant women.
However, consult your doctor before receiving it. Women of childbearing
potential must use a suitable contrace
therapy with IKGDAR 500MG INJECTION and until 12 months after stopping the
therapy. If you accidentally became pregnant while receiving IKGDAR 500MG
INJECTION, inform your doctor immediately.

!### Breastfeeding

ContraindicatedIKGDAR 500MG INJECTION is not recommended for use in breastfeeding women.
Therefore, consult your doctor before receiving it.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if your ability is affected by IKGDAR 500MG
INJECTION.

!### Alcohol

Consult your doctorAvoid consum
make you feel drowsier.

!### Allergy

ContraindicatedTalk to your doctor before receiving IKGDAR 500MG INJECTION if you are allergic
to rituximab.

!### Heart Disease

Consult your doctorIKGDAR 500MG INJECTION is not recommended for use in patients with severe heart
failure or uncontrollable heart problems. It should be used with caution in
patients with other heart problems (such as angina, fast heart rate or heart
failure). Therefore, consult your doctor before receiving it.

Others

IKGDAR 500MG INJECTION is not recommended for use if you:

• have any serious infection that affects the whole body
• have a weak immune system

Before receiving IKGDAR 500MG INJECTION, inform your doctor if you:

• currently have or previously had hepatitis B infection
• are yet to receive any vaccinations
• have any infection (including mild cough and cold)
• have a previous history of severe infections

Use in pediatrics:

IKGDAR 500MG INJECTION should be used in children and adolescents (aged below 18
years) only if prescribed by the physician. Therefore, consult your doctor for
advice before receiving it.

Use in geriatrics:

IKGDAR 500MG INJECTION should be used with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving IKGDAR 500MG INJECTION, inform your doctor if you are taking
any of the following medicines such as:

• medicines used to manage high blood pressure (such as atenolol, propranolol, amlodipine, enalapril, olmesartan, losartan)
• medicines that can suppress immune functions (such as ciclosporin, tacrolimus)
• other anticancer medicines (such as Trastuzumab, Bevacizumab, Alemtuzumab, Cetuximab)

Overdosage:

IKGDAR 500MG INJECTION will be administered to you only by a doctor or a nurse
in a hospital, and so it is unlikely to receive an overdose. However, consult
your doctor if you experience any unusual symptoms.

Synopsis

Drug	:	Rituximab
Pharmacological Category	:	Unarmed Monoclonal Antibody
Therapeutic Indication	:	Autoimmune diseases
Dosage Forms	:	Injection, Infusion

More Information

• Keep IKGDAR 500MG INJECTION out of reach of children
• Store IKGDAR 500MG INJECTION in a refrigerator (between 2-8°C)

FAQs About IKGDAR 500MG INJECTION

Q: What IKGDAR 500MG INJECTION is used for?

A: IKGDAR 500MG INJECTION is used to manage blood cancer (leukaemia) and lymph
cancer (lymphoma). It can also be used to manage various auto-immune disease
conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or
microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris
(severe skin blistering and peeling especially on the mouth, nose, throat, eyes
and genitals).

Q: How IKGDAR 500MG INJECTION works on my body?

A: IKGDAR 500MG INJECTION is a monoclonal antibody. It destroys the immune cells
(B-cells) that triggers cancer formation. It also reduces the production of
certain chemicals within the body (such as rheumatoid factor, T-cells,
cytokines) that causes inflammation, pain and swelling which helps in managing
various autoimmune diseases.

Q: Can IKGDAR 500MG INJECTION manage cancer?

A: The manage rate of cancer depends upon the severity of the disease. However,
IKGDAR 500MG INJECTION acts by managing the abnormal growth and multiplication
of cancer cells in the body, which may help in managing cancer completely.

Q: Can the use of IKGDAR 500MG INJECTION cause hair loss?

A: Hair loss is one of the common side effects of receiving IKGDAR 500MG
INJECTION. If it bothers you, consult your doctor for advice.

Q: Can the use of IKGDAR 500MG INJECTION cause mouth ulcers?

A: Mouth ulcers are one of the common side effects of receiving IKGDAR 500MG
INJECTION. Avoid eating spicy foods. Drink plenty of water. Apply a
pain-relieving gel on the affected areas of the mouth if required. Consult your
doctor if the symptom did not improve.

Q: Can IKGDAR 500MG INJECTION be used in children?

A: IKGDAR 500MG INJECTION should be used in children and adolescents (aged below
18 years) only if prescribed by the physician. Therefore, consult your doctor
for advice before receiving it.

Q: What precautions must be followed while receiving IKGDAR 500MG INJECTION?

A: Before receiving IKGDAR 500MG INJECTION inform your doctor if you have any
heart problems (such as chest pain, heart attack, heart failure or abnormal
heartbeat). You must also inform your doctor if you currently have or previously
had hepatitis B infection or any other mild infections (including minor cough
and cold) as a precaution. IKGDAR 500MG INJECTION is not recommended for use in
pregnant or breastfeeding women. Both men and women receiving IKGDAR 500MG
INJECTION must use a suitable contrace
undergoing therapy with IKGDAR 500MG INJECTION.

Q: What happens if I stop receiving IKGDAR 500MG INJECTION?

A: No. Do not stop receiving IKGDAR 500MG INJECTION without consulting your
doctor as it may make your symptoms reappear. Therefore, take IKGDAR 500MG
INJECTION as advised by your doctor for the stipulated duration.

Q: Can IKGDAR 500MG INJECTION be used during pregnancy?

A: IKGDAR 500MG INJECTION is generally not recommended for use in pregnant
women. If you accidentally became pregnant while receiving IKGDAR 500MG
INJECTION, inform your doctor immediately.

Q: Can the use of IKGDAR 500MG INJECTION make me feel tired?

A: Yes. IKGDAR 500MG INJECTION may make you feel tired easily. This is because,
it reduces the levels of red blood cells in your blood and may make you anaemic.
Consult your doctor if you experience tiredness after receiving IKGDAR 500MG
INJECTION. Tiredness can also occur if you have any pre-existing disease
conditions such as liver or kidney impairment while taking this medicine.

Q: Can I drive a car after receivingIKGDAR 500MG INJECTION?

A: IKGDAR 500MG INJECTION may make you feel tired or dizzy. Therefore, do not
drive or operate any heavy tools or machines if your ability is affected by
IKGDAR 500MG INJECTION.

Q: How IKGDAR 500MG INJECTION is administered?

A: IKGDAR 500MG INJECTION will be given to you only by a doctor or a nurse into
a vein (as an intravenous infusion).

Q: How to control nausea caused due to IKGDAR 500MG INJECTION?

A: Generally, anticancer medicines are associated with uncontrollable nausea and
vomiting. To avoid this, your doctor would prescribe a suitable medicine to
control them along with IKGDAR 500MG INJECTION. If not, consult your doctor for
a suitable anti-emetic medicine. Do not self-manage nausea.

Q: What are the side effects of receiving IKGDAR 500MG INJECTION?

A: The most common side effects of receiving this medicine are fever, chills,
skin rashes with itching, shortness of breath and low blood pressure. Consult
your doctor if any of these side effect worsens.

Useful Diagnostic Tests

• Complete Blood Count
• Peripheral Smear Examination
• Rheumatoid Factor-Agglutination
• Rheumatoid Factor-Turbidometry
• Rheumatoid Factor IgG Antibody