FENOMUNE 500 Tablet 10's

Introduction About FENOMUNE 500 TABLET

FENOMUNE 500 TABLET contains Mycophenolate mofetil which belongs to the group of
medicines called Immunosuppressive agents. It is used to manage the body
rejecting a transplanted organ (such as kidney, heart, and liver). It is also
given with other medications such as corticosteroids and ciclosporin.

Your doctor will perform some regular blood tests to monitor any changes in the
body. FENOMUNE 500 TABLET may increases the risk of skin cancer. Limit your
exposure to sunlight and ultraviolet light by covering the exposed areas of skin
as much as possible and by applying sunscreen with a high protective factor.
FENOMUNE 500 TABLET can cause birth defects and miscarriage, hence it is
strictly not recommended for use in pregnant women and breastfeeding women.

FENOMUNE 500 TABLET is not recommended for use in children under 2 years of age.
Contact your doctor before taking. FENOMUNE 500 TABLET should be used with
caution in elderly patients aged 65 years or above. Contact your doctor before
taking FENOMUNE 500 TABLET. The most common side effects of taking FENOMUNE 500
TABLET are nausea, vomiting, diarrhea, stomach pain, headache, high blood
pressure, and low number of white blood cells. Contact your doctor if the above
side effects worsen.

Uses Of FENOMUNE 500 TABLET

• Used to manage the body rejecting a transplanted organ (such as kidney, heart, and liver)

How FENOMUNE 500 TABLET Works

FENOMUNE 500 TABLET belongs to immunosuppressants which reduces the action of
the body's own defense system (the immune system) and manages rejection of the
transplanted organ.

How to use FENOMUNE 500 TABLET

Take FENOMUNE 500 TABLET as advised by your physician. Swallow the medicines
with a glass of water. Do not crush or chew the medicine. Your dosage will vary
depending on the type of transplant you received. Do not stop the medicine
suddenly without the concern of your doctor.

Side Effects Of FENOMUNE 500 TABLET

Common

• decreased in white blood cells
• decrease in calcium levels of blood
• abnormal potassium levels in the blood (high or low)
• raised uric acid levels in the blood
• high or low blood pressure
• anxiety
• diarrhoea
• joint or muscle pain
• tiredness, shortness of breath and pale skin (decrease in red blood cells)
• unexpected bleeding and bruising (decrease in blood platelets)
• hypomagnesemia (decrease in magnesium levels of blood)
• dizziness
• headache
• cough
• shortness of breath
• stomach pain, inflammation of the lining of the stomach, abdominal bloating, constipation, indigestion, flatulence, loose stools, nausea, vomiting
• tiredness
• fever
• respiratory infection
• acne
• weakness
• swelling of hands, ankles, or feet
• itching

Uncommon

• fast heartbeat or irregular heartbeat
• fluid in the lungs
• presence of cyst in lymph
• trembling, difficulty in sleeping
• conjunctivitis, blurry vision
• bad breath, gas formation, intestinal blockage, ulcers on lips, heartburn, discoloration of tongue, dry mouth, inflammation of the gums
• loss of appetite
• wheezing
• blockage of salivary glands
• elevated lipid levels
• increase in blood glucose levels or blood cholesterol levels
• strange dreams, delusions
• pain, rigors
• inability to keep an erection
• cough, difficulty breathing, painful breathing
• fever, chills, nausea, vomiting, low body temperature, fast heartbeat

Stop taking FENOMUNE 500 TABLET and contact your doctor immediately if you
experience any of the following side effects:

• yellowish discoloration of skin and whites of eyes, nausea, loss of appetite and dark urine
• persistent cough or become breathlessness
• signs of infection such as fever, chills, sore throat, sweating, feeling tired, drowsy, or lack of energy
• blood vomit blood or blood in stools due stomach, or intestinal ulcer
• swelling of glands, development of a new skin growth or enlargement of an existing skin growth, or changes in an existing mole, may lead to development of cancer of the skin or lymph nodes
• rashes, swelling of face, lips, tongue or throat causing difficulty breathing

How To Manage Side Effects

!### Diarrhea

Drink plenty of water and fruit juice to keep yourself hydrated. Contact your
doctor if the diarrhea did not improve.

!### Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines
while you are feeling dizzy. Do not drink alcohol, as it can aggravate your
dizziness. Contact your doctor if the dizziness did not improve.

Headache

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a
pain-relieving balm on the head if necessary. Do not consume alcohol. Contact
your doctor if the headache did not improve.

!### Nausea And Vomiting

Take the medicine, with or just after a meal. Stick to simple meals. Avoid
eating oily or spicy food. Contact your doctor if nausea and vomiting did not
improve.

!### Stomach Pain

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on
your stomach. Contact your doctor if the stomach pain did not improve.

Warning & Precautions

!### Pregnancy

ContraindicatedFENOMUNE 500 TABLET is not recommended for use in pregnant women. Inform your
doctor if you are planning to have a child before taking this medicine. Contact
your doctor before taking FENOMUNE 500 TABLET.

!### Breastfeeding

ContraindicatedFENOMUNE 500 TABLET is generally not recommended for use in breastfeeding women,
hence small amounts of the medicine can pass into the mother’s milk. Contact
your doctor before taking FENOMUNE 500 TABLET.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you feel drowsiness, somnolence,
dizziness, tremor, low blood pressure, numb or confusion after taking FENOMUNE
500 TABLET.

!### Kidney

Use with CautionFENOMUNE 500 TABLET should be used with caution in patients with kidney
diseases. Contact your doctor before taking FENOMUNE 500 TABLET.

!### Liver

Use with CautionFENOMUNE 500 TABLET should be used with caution in patients with liver diseases.
Contact your doctor before taking FENOMUNE 500 TABLET.

!### Allergy

ContraindicatedDo not take FENOMUNE 500 TABLET if you are allergic (hypersensitive) to
Mycophenolate mofetil, or to some sugars such as lactose, galactose, or glucose
or to other ingredients of this medicine.

!### Lungs

Use with CautionFENOMUNE 500 TABLET should be used with caution in patients with lung diseases.
Contact your doctor before taking FENOMUNE 500 TABLET.

!### Heart Disease

Use with CautionFENOMUNE 500 TABLET should be used with caution in patients with heart diseases.
Contact your doctor before taking FENOMUNE 500 TABLET.

!### Use In Pediatrics

ContraindicatedFENOMUNE 500 TABLET is not recommended for use in children under the age of 2,
because there is limited information on its safety and effectiveness. Contact
your doctor before taking FENOMUNE 500 TABLET.

!### Use In Geriatrics

Use with CautionFENOMUNE 500 TABLET should be used with caution in elderly patients aged 65
years or above. Contact your doctor before taking FENOMUNE 500 TABLET.

Others

FENOMUNE 500 TABLET is not recommended for use if you:

• have hereditary enzyme deficiency such as Lesch-Nyhan (neurogenetic disorder) and Kelley-Seegmiller syndrome (partial deficiency of the enzyme hypoxanthine gu

Before taking FENOMUNE 500 TABLET, inform your doctor if you:

• have any unexpected bruising (skin discoloration from a skin or tissue injury) or bleeding
• have digestive problems (such as a stomach ulcer)
• have a rare problem with your metabolism called phenylketonuria (hereditary condition that results in an accumulation of the phenylal
• are planning to get live vaccinations
• have Hepatitis B or C infections
• have skin cancer or lymphoma

Interactions

A. Drug-Drug interactions:

Before taking FENOMUNE 500 TABLET, inform your doctor if you are taking any of
the following medicine:

• azathioprine, tacrolimus, belatacept, cyclosporine A (suppress your immune system given after a transplant operation)
• cholestyramine (medicine used to manage high cholesterol)
• rifampicin (medicines used to manage infections such as TB)
• medicines used to manage ulcer problems (antacids such as aluminium hydroxide, magnesium hydroxide, sodium bicarbonate, calcium carbonate or proton pump inhibitors such as omeprazole, rabeprazole, pantoprazole)
• phosphate binders (used to reduce phosphate absor
• antibiotics (medicines used to manage bacterial infections) amoxicillin and clavul
• isavuconazole (medicine used to manage fungal infections)
• telmisartan (medicine used to manage high blood pressure)
• activated charcoal (used to manage digestive problems)
• acyclovir or ganciclovir (medicines used to manage viral infections)
• oral contrace
• probenecid (medicines used to manage gout)
• iron salts such as Ex. ferrous sulphate (medicines used to manage iron deficiency)

Overdosage:

If you or anyone else accidentally takes too much of FENOMUNE 500 TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms include
nausea, vomiting, diarrhea, and neutropenia.

Synopsis

Drug	:	Mycophenolate mofetil
Pharmacological Category	:	Immunosuppressants
Therapeutic Indication	:	Used to manage the body rejecting a transplanted organ (such as kidney, heart, and liver)
Dosage Forms	:	Tablet, Capsule, Suspension, Oral suspension

More Information

Storage

• Keep FENOMUNE 500 TABLET out of the sight and reach of children
• Store FENOMUNE 500 TABLET below 30°C

FAQs About FENOMUNE 500 TABLET

Q: What is FENOMUNE 500 TABLET used for?

A: FENOMUNE 500 TABLET is used to manage your body from rejecting an organ
transplant (such as kidney, heart, and liver). Contact your doctor before taking
FENOMUNE 500 TABLET.

Q: Can I use FENOMUNE 500 TABLET in pregnancy?

A: No. FENOMUNE 500 TABLET is strictly not recommended for use in pregnant women
unless considered necessary. Contact your doctor before taking FENOMUNE 500
TABLET.

Q: Is FENOMUNE 500 TABLET safe?

A: Yes, FENOMUNE 500 TABLET is safe and well tolerated. Contact your doctor
before taking.

Q: Can I use FENOMUNE 500 TABLET in children?

A: No, FENOMUNE 500 TABLET is not recommended for use in children under the age
of 2, because there is limited information on its safety and effectiveness for
them. Contact your doctor before taking.

Q: How FENOMUNE 500 TABLET work?

A: FENOMUNE 500 TABLET belongs to immunosuppressants which reduces the action of
the body's own defense system (the immune system) and manages rejection of the
transplanted organ.

Q: Can I use FENOMUNE 500 TABLET while breast feeding?

A: No. FENOMUNE 500 TABLET is generally not recommended for use in breastfeeding
women, small amounts of the medicine can pass into the mother’s milk. Contact
your doctor before taking it.

Useful Diagnostic Tests

• Complete blood count
• Liver function test
• Kidney function test