ENATRATE Injection 1ml

Introduction About ENATRATE INJECTION

ENATRATE INJECTION contains Adrenaline which belongs to the group of medicines
called Sympathomimetics. It is used during emergency situations to manage severe
allergic reactions (anaphylaxis), cardiac arrest (loss of heart functions) and
anaphylactic shock (sudden drop in blood flow due to an allergic reaction).

Anaphylaxis can be defined as a severe, potential life-threatening medical
condition characterized by severe decrease in blood pressure, heart function,
skin rash, nausea, swelling of the face, lips, tongue, or throat causing
difficulty in breathing or swallowing. It is caused when an individual
accidentally gets exposed towards certain chemicals (such as insect stings or
bites, foods, drugs, sera, diagnostic testing substances and other allergens)
that can trigger an allergic reaction in him.

ENATRATE INJECTION can also be used to increase blood pressure in patients
suffering from low blood pressure caused due to se
inducing mydriasis (dilation of the pupils) prior to an eye surgery after
diluting the medicine properly using an ophthalmic irrigating solution.

Before receiving ENATRATE INJECTION inform your doctor if you have any liver,
kidney, or severe heart problems. You must also inform your doctor if you have
diabetes, hypertension, glaucoma, thyroid disorders, atherosclerosis, or any
other brain disorders.

Inform your doctor before receiving ENATRATE INJECTION if you are pregnant or
breastfeeding. The common side effects of receiving ENATRATE INJECTION are
tremors, pounding heartbeat, headache, sweating or dizziness. Inform your doctor
if any of these side effects worsens.

Uses Of ENATRATE INJECTION

It is used to:

• manage severe allergic reactions (anaphylaxis)
• manage anaphylactic shock
• manage cardiac arrest and to restore blood pressure
• induce mydriasis (dilation of the pupil) prior to an eye surgery

How ENATRATE INJECTION Works

ENATRATE INJECTION is a powerful cardiac stimulant. It works by binding to the
alpha and beta receptors of the adrenergic system. This action, stimulates the
heart, improves heart functions, and helps the heart to pump more blood
smoothly. It also increases blood pressure among patients suffering from low
blood pressure. It is also a powerful bronchodilator which relaxes the smooth
muscle of the airway tract. This helps in reducing breathing difficulties caused
due to anaphylactic reactions.

How to use ENATRATE INJECTION

ENATRATE INJECTION will be given only by a doctor or by a trained healthcare
professional into the vein (intravenously) or into the muscle (intramuscularly)
or under the skin (subcutaneously on the anterior part of the thigh).

It may also be administered into the eye (intracamerally) by an ophthalmologist
prior to an eye surgery after diluting the medicine properly using an ophthalmic
irrigating solution to cause pupil dilation.

Your doctor will decide the correct dose, duration of therapy and site of
administration for you depending upon your age, body weight and health
condition. However, care should be taken to not to administer ENATRATE INJECTION
in areas which generally have low blood supply (such as fingers, toes, ears,
nose, genitals, or buttocks).

Side Effects Of ENATRATE INJECTION

Common

• anxiety or restlessness
• apprehensiveness (a sense of misfortune)
• shivering or shaking
• weakness, dizziness
• headache
• sweating or irregular or pounding heart rate
• pale appearance of the skin
• nausea and vomiting
• difficulty in breathing

Rare

Consult your doctor if you experience any of the following side effects after
receiving ENATRATE INJECTION:

• severe allergic reactions (such as wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching all over the body)
• signs of stress cardiomyopathy (such as chest pain, breathing difficulty, nausea, irregular heartbeat)

How To Manage Side Effects

!### Dizziness Or Drowsiness

Try to rest and relax. Avoid driving or operating heavy tools or machines while
you are feeling dizzy. Avoid consum
dizziness did not improve.

Headache

Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom
does not improve, consult with your doctor.

Warning & Precautions

!### Pregnancy

Monitoring requiredENATRATE INJECTION should be used in pregnant women only if considered necessary
by the physician. Therefore, inform your doctor before receiving ENATRATE
INJECTION if you are pregnant or think you may be pregnant or planning to have a
baby.

!### Breastfeeding

Monitoring requiredENATRATE INJECTION should be used in breastfeeding women only if considered
necessary by the physician. Therefore, inform your doctor before receiving
ENATRATE INJECTION if you are breastfeeding.

!### Driving and Using Machines

Use with CautionDo not drive or operate any machines if you experience dizziness or any other
symptoms that affects your ability to drive after receiving ENATRATE INJECTION.

!### Kidney

Use with CautionENATRATE INJECTION should be used with caution in patients with kidney diseases.
Therefore, consult your doctor before receiving it.

!### Liver

Use with CautionENATRATE INJECTION should be used with caution in patients with liver disease.
Therefore, consult your doctor before receiving it.

!### Allergy

ContraindicatedDo not receive ENATRATE INJECTION if you are allergic to Adrenaline.

!### Heart Disease

Consult your doctorENATRATE INJECTION is not recommended for use in patients with severe heart
disease which involves an increased heart rate. It should be used with caution
in patients with other heart problems (such as high blood pressure). Therefore,
consult your doctor before receiving it.

!### Use In Pediatrics

Use with CautionENATRATE INJECTION should be used with caution in children and adolescents (aged
below 18 years). Therefore, consult your doctor before receiving it.

!### Use In Geriatrics

Use with CautionENATRATE INJECTION should be used with caution in elderly patients. Therefore,
consult your doctor before receiving it.

Others

ENATRATE INJECTION is not recommended for use if you:

• have any infection, disease, or tumor in the brain

Before receiving ENATRATE INJECTION, inform your physician if you:

• have chest pain
• have blood vessel damage in your brain
• have diabetes
• have high blood pressure
• have glaucoma (increased pressure in the eye)
• have an overactive thyroid
• have low potassium levels in the blood
• have high calcium level in the blood
• have phaeochromocytoma (a tumor present on the adrenal gland)
• have a tumor in the prostate gland
• have severe blood loss
• are going to have a surgery under general anesthesia
• have atherosclerosis (deposition of fat particles within the blood vessel that affects blood flow)

Interactions

A. Drug-Drug interactions:

Before receiving ENATRATE INJECTION, inform your doctor if you are taking any of
the following medicines such as:

• antidepressants (used to manage depression) such as monoamine oxidase inhibitors (Ex. phenelzine, selegiline, isocarboxazid) or tricyclic antidepressants (Ex. imipramine, amitriptyline)
• cardiac glycosides (used to manage abnormal heart rhythm) such as digoxin
• guanethidine (a medicine used to high blood pressure)
• diuretics (used to reduce edema by increasing urine output) such as hydrochlorothiazide, furosemide
• inhaled general anesthetics (used to cause loss of consciousness) such as halothane
• medicines used to control blood pressure (such as atenolol, propranolol, phentolamine, bisoprolol)
• medicines used to manage diabetes (such as insulin or glipizide)
• aminophylline and theophylline (medicines used to improve breathing)
• corticosteroids (medicines used to manage inflammatory conditions in your body such as asthma or arthritis) Ex. dexamethasone, prednisolone, methylprednisolone
• antihistamines (used to manage allergic conditions) Ex. diphenhydramine
• medicines used to manage psychiatric disorders (such as chlorpromazine or fluphenazine)
• medicines used to manage thyroid deficiency (Ex. thyroxine)
• oxytocin (a medicine used to induce labor)
• cough preparations (such as ambroxol, terbutaline, chlorpheniramine)

Overdosage:

ENATRATE INJECTION will be given to you only by a doctor or nurse in a hospital,
and so it is unlikely to receive an overdose. However, inform your doctor
immediately if you experience any unusual symptoms.

Synopsis

Drug	:	Adrenaline
Pharmacological Category	:	Adrenergic Agonists
Therapeutic Indication	:	Anaphylactic reactions, Shock, Cardiac Arrest, Mydriasis
Dosage Forms	:	Injection

More Information

• Keep ENATRATE INJECTION out of reach of children
• Store ENATRATE INJECTION at room temperature
• Protect ENATRATE INJECTION from direct sunlight

FAQs About ENATRATE INJECTION

Q: What is the use of ENATRATE INJECTION?

A: ENATRATE INJECTION is used during emergency situations to manage severe
allergic reactions (anaphylaxis), cardiac arrest (loss of heart functions) and
anaphylactic shock (sudden drop in blood flow due to an allergic reaction). It
can also be used to increase blood pressure in patients suffering from low blood
pressure caused due to se
(dilation of the pupils) prior to an eye surgery after diluting the medicine
properly using an ophthalmic irrigating solution.

Q: Is ENATRATE INJECTION safe?

A: ENATRATE INJECTION is safe when used under proper medical supervision and at
the prescribed doses.

Q: What ENATRATE INJECTION does to my heart?

A: ENATRATE INJECTION is a powerful cardiac stimulant. It works by binding to
the alpha and beta receptors of the adrenergic system. This action, stimulates
the heart, improves heart functions, and helps the heart to pump more blood
smoothly. It also increases blood pressure among patients suffering from low
blood pressure.

Q:Can ENATRATE INJECTION be used to manage emergency conditions?

A: Yes. [GBNKEYWORD can be used during emergency conditions like cardiac arrest,
anaphylaxis, and anaphylactic shock.

Q: What precautions do I need to follow while taking ENATRATE INJECTION?

A:Patients receiving ENATRATE INJECTION must inform their doctor about their
pre-existing disease conditions such as high blood pressure, diabetes, glaucoma,
liver problems, kidney problems, heart problems or thyroid problems. It is also
important to inform your doctor if you are pregnant or breastfeeding before
receiving ENATRATE INJECTION.

Q: How ENATRATE INJECTION is administered?

A: ENATRATE INJECTION will be given only by a doctor or by a trained healthcare
professional into the vein (intravenously) or into the muscle (intramuscularly)
or under the skin (subcutaneously on the anterior part of the thigh). It may
also be administered into the eye (intracamerally) by an ophthalmologist prior
to an eye surgery after diluting the medicine properly using an ophthalmic
irrigating solution to cause pupil dilation.

Q: Can ENATRATE INJECTION cause an increase in heart rate?

A: Yes. ENATRATE INJECTION is known to increase heart rate and is used to
restore your heart rate during emergency conditions like cardiac failure.

Q: Can ENATRATE INJECTION cause high blood pressure?

A: Yes. ENATRATE INJECTION can be used to increase blood pressure in patients
suffering from low blood pressure caused due to se
it should be used with caution in patients having hypertension. Therefore,
inform your doctor before receiving it.

Q: Can ENATRATE INJECTION cause dizziness?

A: Yes. ENATRATE INJECTION may cause dizziness in some individuals after
administration. Try to rest and relax. Avoid driving or operating heavy tools or
machines while you are feeling dizzy. Avoid consum
doctor if your dizziness did not improve.

Q: Is ENATRATE INJECTION safe for use during pregnancy?

A: ENATRATE INJECTION should be used in pregnant women only if considered
necessary by the physician. Therefore, inform your doctor before receiving
ENATRATE INJECTION if you are pregnant or think you may be pregnant or planning
to have a baby.

Useful Diagnostic Tests

• Absolute Eosinophil count
• Total IgE