COMBUTOL 600MG TABLET 10'S

Introduction About COMBUTOL 600MG TABLET

COMBUTOL 600MG TABLET contains ethambutol, which belongs to the group of
medicines called antituberculous drugs. Tuberculosis (TB) is a potentially
serious infectious disorder caused by a bacterium called Mycobacterium
tuberculosis. The bacteria usually attack the lungs, but they can attack any
part of the body, such as the kidney, spine and brain. This bacterium can spread
from one person to another through tiny droplets released into the air via
coughs and sneezes.

COMBUTOL 600MG TABLET is not recommended in patients with o
problems). Before taking COMBUTOL 600MG TABLET, inform your doctor if you have
kidney problems, liver problems, diabetes or blood disorders. COMBUTOL 600MG
TABLET is not recommended for use among pregnant women and breastfeeding women.

COMBUTOL 600MG TABLET is not recommended for use in children less than 13 years
of age and it should be used with caution in children 13 years of age and older
and elderly patients (above 65 years of age). The most common side effects of
taking COMBUTOL 600MG TABLET are inflammation of the o
sharpness of vision. Contact your doctor if any of the above symptoms worsen.

Uses Of COMBUTOL 600MG TABLET

• Manage pulmonary tuberculosis

How COMBUTOL 600MG TABLET Works

COMBUTOL 600MG TABLET contains Ethambutol which is a bacteriostatic agent that
works by inhibiting the arabinosyl transferase, an enzyme that polymerizes
arabinose into arabinan and then arabinogalactan, a mycobacterial cell wall
constituent. This manages cell division.

How to use COMBUTOL 600MG TABLET

Take COMBUTOL 600MG TABLET as advised by your doctor. Swallow the medicine with
enough water. Do not crush or chew the medicine. Try to take COMBUTOL 600MG
TABLET daily at the same time. Your doctor will decide the correct dose and
duration of COMBUTOL 600MG TABLET for you depending on your age, body weight and
disease condition.

Side Effects Of COMBUTOL 600MG TABLET

Common

• eye problems (like inflammation of the o

Uncommon

• hyperuricemia (high level of uric acid in the blood)

Rare

• the sensation of numbness, pins and needles
• low blood platelet count
• minor allergic reactions (signs include rashes, itching and swollen, pale red bumps or plaques (wheals) on the skin)

Stop taking COMBUTOL 600MG TABLET and contact your physician immediately if you
experience any of the side effects that worsen the existing disease:

• severe allergic reaction (signs include difficulty breathing, sudden wheeziness, swelling of the face, eyes, lips, or throat, flushed appearance and irregular heartbeat)
• eye problems (like changes in the eyesight including loss of vision, blurred vision, eye pain, or color blindness)
• blistering or peeling of skin (including following exposure to sunlight), red or purple rash
• Stevens-Johnson syndrome (signs include skin rash and itching with peeling and blistering and a sore mouth, hard lumps and red patches often on the backs of arms and hands)
• liver problem (signs include pale stools or skin or whites of eyes become yellow)
• kidney problem (signs include difficulty in urinating and low back pain)
• blood disorder (signs include unusual bleeding, bruising or discolored skin)

Warning & Precautions

!### Pregnancy

COMBUTOL 600MG TABLET is generally not recommended to use in pregnant women
unless considered necessary. Consult your doctor before taking it.

!### Breastfeeding

COMBUTOL 600MG TABLET is generally not recommended to use in breastfeeding
women. Consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any machines if you feel problems with eyesight,
dizziness, disorientation or tingling/numbness in the hands or feet after taking
COMBUTOL 600MG TABLET.

!### Kidney

COMBUTOL 600MG TABLET should be used with caution in patients with renal
[kidney] problems. Consult your doctor taking it.

!### Liver

[GBNAKEYWORD] should be taken with caution in patients with liver problems.
Consult your doctor before taking it.

!### Allergy

Do not take COMBUTOL 600MG TABLET if you are allergic to Ethambutol or any of
the other ingredients of this medicine.

Others

COMBUTOL 600MG TABLET is not recommended for use if you have:

• o

Before taking COMBUTOL 600MG TABLET, inform your doctor if you have:

• diabetes
• blood disorders

Use in pediatrics:

COMBUTOL 600MG TABLET is not recommended to use in children below 13 years of
age and it should be used with caution in children 13 years of age and above.
Consult your doctor before taking it.

Use in geriatrics:

COMBUTOL 600MG TABLET should be used with caution in elderly patients (65 years
and above). Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking COMBUTOL 600MG TABLET, inform your doctor if you are taking any of
the following medicine:

• medicines used to manage heartburn and indigestion (Ex. antacids containing aluminum hydroxide)

Overdosage:

If you or anyone else accidentally took more of COMBUTOL 600MG TABLET, consult
your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Ethambutol
Pharmacological Category	:	Antituberculous drugs
Therapeutic Indication	:	Tuberculosis
Dosage Forms	:	Tablet, Capsule

More Information

• Keep COMBUTOL 600MG TABLET out of reach from children
• Store at a temperature, not more than 30°C

FAQs About COMBUTOL 600MG TABLET

What if I forget to take a dose of COMBUTOL 600MG TABLET?

If you forget a dose of COMBUTOL 600MG TABLET, take it as soon as you remember.
However, if it is almost time for the next dose, skip the missed dose and take
the next scheduled dose at the prescribed time. Do not double the dose to make
up for the missed dose, as this may increase the chances of developing side
effects.

How and when should COMBUTOL 600MG TABLET be taken?

Take COMBUTOL 600MG TABLET as advised by your doctor. Swallow the medicine with
enough water. Do not crush or chew the medicine. Try to take COMBUTOL 600MG
TABLET daily at the same time. Your doctor will determine the correct dose and
duration of COMBUTOL 600MG TABLET for you depending on your age, body weight and
disease condition.

How long should I use COMBUTOL 600MG TABLET to see the results?

Your management depends on your age, body weight and disease condition. After
this, your doctor will decide on the correct dose and determine the duration of
the course of COMBUTOL 600MG TABLET to see the results.

Is driving a car safe after taking COMBUTOL 600MG TABLET?

Do not drive or operate any machines if you feel problems with eyesight,
dizziness, disorientation or tingling or numbness in the hands or feet after
taking COMBUTOL 600MG TABLET.

Can I give COMBUTOL 600MG TABLET to pregnant women?

No, COMBUTOL 600MG TABLET is not recommended for use among women who are
pregnant or breastfeeding, unless considered necessary. Consult your doctor
before taking it.

Is COMBUTOL 600MG TABLET safe to use in infants?

No. COMBUTOL 600MG TABLET is not recommended for use in children below 13 years
of age and should be used with caution in children 13 years of age and older.
Consult your doctor before taking it.

When is COMBUTOL 600MG TABLET not to be used?

COMBUTOL 600MG TABLET is not recommended for use in patients with o
(eye problems), pregnant women, breastfeeding women or children below 13 years
of age. COMBUTOL 600MG TABLET should be used with caution in patients with
kidney problems, liver problems, diabetes, children 13 years of age and older
and elderly patients (above 65 years of age). Consult your doctor before taking
it.

Useful Diagnostic Tests

• Complete blood count
• Erythrocyte sedimentation rate
• Mycobacterium tuberculosis DNA PCR - qualitative
• Peripheral smear examination