Acedip Tablet 10'S

Introduction About ACEDIP TABLET

ACEDIP TABLET is a combination of Amlodipine and Lisinopril which belongs to the
group of medicines called Antihypertensive agents. It is used to manage
hypertension (high blood pressure) and certain type of angina (chest pain)
called as Prinzmetal or variant angina. It can also be used to manage heart
failure and reduce the chances of hospitalization among the heart patients.

It also protects the function of kidneys particularly in patients who have both
hypertension and type II diabetes mellitus.

Before taking ACEDIP TABLET inform your doctor if you have any liver or kidney
problems. You must also inform your doctor if you have any other heart problems
apart from hypertension, angina and heart failure (such as cardiogenic shock or
narrowing of heart valves).

Talk to your doctor if you are on a low salt diet or have diabetes or are
severely dehydrated due to any recent sickness (such as vomiting or diarrhea)
before taking ACEDIP TABLET as a precaution.

ACEDIP TABLET is not recommended for use in patients with severe hypotension
(low blood pressure). It is also not suitable for use in women who are pregnant
or breastfeeding due to increased risk of side effects.

The most common side effects of taking ACEDIP TABLET are dizziness, swelling of
ankles or other body parts, headache, sleepiness, tiredness, racing heartbeat,
indigestion, constipation and muscle cramps. Contact your doctor if any of these
side effects trouble you.

Uses Of ACEDIP TABLET

It is used to:

• Manage hypertension and angina
• Prevent heart failure
• Protects kidney functions in patients with hypertension and diabetes

How ACEDIP TABLET Works

ACEDIP TABLET is a vasodilator. It relaxes the blood vessels supplying the heart
and other organs (such as kidneys). This improves blood flow and oxygen supply
to the heart muscles which reduces strain on the heart.

It also allows blood to flow more smoothly across the blood vessels with less
pressure. It can improve blood supply to the kidneys which helps in improving
kidney functions among diabetic patients. As a result, it reduces blood pressure
and improves the functions of the heart and the kidneys.

How to use ACEDIP TABLET

Take ACEDIP TABLET as advised by your physician. Swallow the medicines with a
glass of water. Do not crush or chew the medicine. ACEDIP TABLET can be taken
with or without food.

Your doctor will decide the correct dose and duration of therapy for you
depending upon your age, body weight and disease condition.

Continue to take ACEDIP TABLET for the stipulated duration instructed by your
doctor to achieve better results.

Side Effects Of ACEDIP TABLET

Common

• edema (swelling of the ankles or other body parts)
• headache, dizziness, sleepiness
• palpitations (fast heartbeat)
• flushing (redness and warmth of the skin)
• stomach pain, nausea, diarrhea, constipation, indigestion
• changes in bowel habit
• tiredness, weakness
• blurred vision, double vision
• muscle pains
• dry cough, sinus inflammation

Uncommon

• anxiety, depression
• insomnia (sleeplessness)
• changes in taste
• tingling sensation in limbs, loss of pain sensation
• ringing in the ears
• increased sweating
• increased urination at night
• inability to obtain an erection, enlargement of the breasts in men
• joint pain, back pain
• increased potassium levels in blood

Rare

• confusion
• red, swollen tongue
• loosening or separation of a nail from its bed
• skin rash, itching, redness
• red, itchy, swollen or watery eyes
• low RBC, WBC and platelet counts

Stop taking ACEDIP TABLET and contact your doctor immediately if you experience
any of the following side effects:

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
• severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
• chest pain, shortness of breath (signs of heart attack)
• signs of stroke (such as weakness or numbness down on one side of the body, confusion, slurred speech, difficulty in concentrating)
• signs of kidney failure (decreased urine, cloudy or blood in urine with low back pain, nausea or vomiting, fluid retention in legs, ankles or feet)
• inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
• sever stomach pain due to obstruction of the gut or inflammation of pancreas
• dizziness, fainting or lightheadedness, excessive sweating following an exercise or after regular activities (signs of low RBC count in blood)
• signs of liver problems (such as fever, muscle pain, rashes, itching, stomach pain, diarrhea, discoloration of eyes, skin and urine)
• increased infections, fever, bleeding or bruising

How To Manage Side Effects

Nausea and vomiting:

Take ACEDIP TABLET with or just after a meal or a snack. Stick to simple meals.
Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or
machines completely while you are feeling dizzy. Do not consume excessive
alcohol, as it could aggravate your dizziness. Consult your doctor if your
dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as
water or electrolytes. Applying a pain-relieving balm on your forehead can be
beneficial. Do not consume excessive alcohol, as it could aggravate your
headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals.
Drink plenty of fluids. Exercise more regularly. Consult your doctor if this
side effect bothers you.

Warning & Precautions

!### Pregnancy

ACEDIP TABLET is not recommended for use in pregnant women as it may cause
serious harm to the growing fetus. Therefore, inform your doctor before taking
this medicine if you are pregnant, think you may be pregnant or planning to have
a baby. If you accidentally become pregnant while undergoing therapy with ACEDIP
TABLET, inform your doctor immediately.

!### Breastfeeding

ACEDIP TABLET is not recommended for use in breast-feeding women. Therefore,
consult your doctor before taking it.

!### Driving and Using Machines

Do not drive or operate any heavy tools or machines if you feel dizzy after
taking ACEDIP TABLET.

!### Alcohol

Avoid consum
decrease your blood pressure and make you feel dizzier or faint.

!### Kidney

ACEDIP TABLET is not recommended for use in patients with severe kidney
impairment (including dialysis or narrowing or renal arteries). It should be
used with caution in patients with other kidney problems (including kidney
transplantation). Therefore, consult your doctor before taking it.

!### Liver

ACEDIP TABLET should be used with caution in patients with liver problems.
Therefore, consult your doctor before taking it.

!### Allergy

Do not take ACEDIP TABLET if you are allergic to Amlodipine, Lisinopril or to
any other calcium antagonists (such as nifedipine, diltiazem) or ACE inhibitors
(such as captopril, enalapril).

!### Heart Disease

ACEDIP TABLET is not recommended for use in patients with severe heart problems
such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic
shock (inability of heart to pump blood). It should be used with caution in
patients having a history of recent heart attack or heart failure. Therefore,
consult your doctor before taking it.

Others

ACEDIP TABLET is not recommended for use if you:

• have severe low blood pressure (hypotension)
• have diabetes with impaired kidney functions

Before taking ACEDIP TABLET, inform your doctor if you have:

• severe uncontrollable increase in blood pressure (hypertensive crisis)
• have problems in the blood vessels supplying the brain
• are on a salt-restricted diet
• are severely dehydrated due to any recent sickness such as vomiting or diarrhea
• have low WBC, RBC and platelet count in the blood
• have diabetes
• have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis or scleroderma)
• are scheduled for any upcoming surgery
• are scheduled for LDL apheresis (a procedure to remove cholesterol from the blood)
• have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
• have high blood potassium levels
• previously had stroke or mini stroke

Use inPaediatrics:

ACEDIP TABLET can be used in children and adolescents (aged between 6-18 years)
if prescribed by a physician. It is not recommended for use in children aged
below 6 years. Therefore, consult your doctor before consum

Use in Geriatrics:

ACEDIP TABLET should be used with caution in elderly patients. Therefore,
consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking ACEDIP TABLET, inform your doctor if you are taking any of the
following medicines such as:

• racecadotril (a medicine used to manage diarrhea)
• medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
• trimethoprim containing antibiotics (used for infections)
• medicines used to manage organ transplant rejection (Ex. ciclosporin, temsirolimus, sirolimus, everolimus)
• heparin (used to manage blood clots)
• medicines used for heart conditions such as hypertension, chest pain, irregular heartbeats or heart failure (Ex. atenolol, propranolol, furosemide, bumet
• lithium (a medicine used in some types of mental illness)
• tricyclic antidepressants (used to manage depression) Ex. amitriptyline
• antipsychotics (used to manage serious mental illnesses) Ex. clozapine, risperidone
• anesthetics (used to manage pain during surgery) Ex. propofol, thiopental, proparacaine, lignocaine
• medicines used to relieve pain (Ex. morphine, aspirin, ibuprofen, celecoxib, valdecoxib)
• thrombolytics (used to dissolve blood clots) Ex. reteplase, tenecteplase
• gold therapy (used to manage rheumatic conditions)
• medicines used to suppress cough (such as dextromethorphan, guaiphenesin, pseudoephedrine)
• anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagli
• other medicines used to manage high blood pressure or angina (Ex. diltiazem, verapamil)
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir, indinavir, nelfinavir (used in management of HIV infections)
• rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
• dantrolene (a medicine used to manage muscle spasms)
• medicines used to control elevated cholesterol levels (Ex. simvastatin)
• St. John’s wort (an herbal medicine used to manage depression)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking ACEDIP TABLET, as it could reduce
your blood pressure to an abnormal level.

Overdosage:

If you or anyone else accidentally took more ACEDIP TABLET, consult your doctor
immediately or visit the nearby hospital. Symptoms of overdosage might include
dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin,
fast heartbeat, anxiety, cough and shortness of breath.

Synopsis

Drug	:	Amlodipine, Lisinopril
Pharmacological Category	:	Calcium Channel Blockers, ACE inhibitors
Therapeutic Indication	:	Hypertension, Angina, Heart Failure, Kidney Failure
Dosage Forms	:	Tablet

More Information

• Keep ACEDIP TABLET out of the sight and reach of children
• Store ACEDIP TABLET at room temperature

FAQs About ACEDIP TABLET

What are the uses of ACEDIP TABLET?

ACEDIP TABLET is used to manage hypertension (high blood pressure) and certain
type of angina (chest pain). It can also be used to manage heart failure and
reduce the chances of hospitalization among the heart patients. It also protects
the function of kidneys particularly in patients who have both hypertension and
type II diabetes mellitus.

How ACEDIP TABLET works?

ACEDIP TABLET is a vasodilator. It relaxes the blood vessels supplying the heart
and other organs. This improves blood flow and oxygen supply to the heart
muscles which reduces strain on the heart. It also allows blood to flow more
smoothly across the blood vessels with less pressure. It can improve blood
supply to the kidneys which helps in improving kidney functions among diabetic
patients. As a result, it reduces blood pressure and improves the functions of
the heart and the kidneys.

What happens when I stop taking ACEDIP TABLET?

Do not stop taking ACEDIP TABLET without consulting your doctor as your symptoms
may re-appear once again. Make sure to take ACEDIP TABLET for the stipulated
duration recommended by your doctor to achieve maximum results.

What is the best time to take ACEDIP TABLET?

ACEDIP TABLET can be taken with or without meals. Your doctor will decide the
best time for you to take ACEDIP TABLET based on your age, body weight and
disease condition.

What to do if I forgot to take a dose of ACEDIP TABLET?

If you have missed a dose of ACEDIP TABLET, take it as soon as you remember.
However, if it is time for the next dose of ACEDIP TABLET, skip the missed dose
and take the next one regularly. Do not take a double dose of ACEDIP TABLET to
compensate the missed ones.

What precautions should be followed while taking ACEDIP TABLET?

Before taking ACEDIP TABLET, inform your doctor if you have any liver or kidney
problems. You must also inform your doctor if you have severe high or low blood
pressure or other heart problems (such as narrowing of the arteries, cardiogenic
shock or a recent heart attack). Do not take ACEDIP TABLET if you are pregnant
or breastfeeding. Regularly visit your doctor and take all the necessary blood
tests recommended by your doctor without fail.

Can I consume alcohol while taking ACEDIP TABLET?

Avoid consum
feel dizzier and drowsier.

What happens if I accidentally take more ACEDIP TABLET?

If you or anyone else accidentally took more ACEDIP TABLET, consult your doctor
immediately. Symptoms of overdosage might include dizziness, fainting,
light-headedness, weakness, shock, cool or clampy skin fast heartbeat, anxiety,
cough and shortness of breath.

Can I take ACEDIP TABLET daily?

Take ACEDIP TABLET as advised by your physician. Your doctor will evaluate your
health condition and suggests whether can you take ACEDIP TABLET every day or
not.

Can ACEDIP TABLET cause ankle swelling?

ACEDIP TABLET may cause edema or swelling of ankles in few patients. If you
experience ankle swelling, keep your legs on a table or slightly elevated from
the ground level. If this symptom bothers you, contact your doctor.

What are the side effects of ACEDIP TABLET?

The most common side effects of taking ACEDIP TABLET are dizziness, swelling of
ankles or other body parts, headache, sleepiness, tiredness, racing heartbeat,
indigestion, constipation and muscle cramps. Contact your doctor if any of these
side effects trouble you.

Can I stop taking ACEDIP TABLET once my symptoms subside?

No. Do not stop taking ACEDIP TABLET without consulting your doctor. As
hypertension is a chronic condition, long term management may be necessary to
control its symptoms. Therefore, take ACEDIP TABLET as advised by your doctor
for the stipulated duration. Sudden withdrawal of the therapy may increase your
blood pressure once again.

Can the use of ACEDIP TABLET affect the liver?

Yes. ACEDIP TABLET may affect the way your liver work. Therefore, it should be
used with caution in patients with liver problems. Consult your doctor before
taking it.

Can ACEDIP TABLET cause erectile dysfunction?

ACEDIP TABLET may cause problems in erection in few individuals. Consult your
doctor if it bothers you.

Is ACEDIP TABLET safe to use in diabetic patients?

ACEDIP TABLET may alter the blood sugar levels in your body. It can also hide
the symptoms of low blood sugar. Therefore, it is necessary to inform your
doctor if you have diabetes before taking ACEDIP TABLET as a precaution. Your
doctor will closely monitor your blood sugar levels to avoid the risk of side
effects. Also, inform your doctor if you experience any unusual tiredness,
hunger or thirst while undergoing therapy with ACEDIP TABLET.

Can ACEDIP TABLET be used during pregnancy?

ACEDIP TABLET is not recommended for use in pregnant women as it may cause
serious harm to the growing foetus. Therefore, inform your doctor before taking
ACEDIP TABLET if you are pregnant, think you may be pregnant or planning to have
a baby.

What kind of foods should be avoided while takingACEDIP TABLET?

ACEDIP TABLET has the capacity to increase blood potassium level which can lead
to irregular heartbeat. To manage any such occurrence, it is advisable to avoid
potassium rich foods such as bananas, oranges, green leafy vegetables and
potassium containing supplements while taking ACEDIP TABLET.

Useful Diagnostic Tests

• Kidney Function Test